STRINGSTRING
metF metF metE metE tyrC tyrC lysC lysC asd asd AIJ32731.1 AIJ32731.1 metX metX metZ metZ sseA_1 sseA_1 aroA aroA HisN HisN serC serC cysQ cysQ AIJ33081.1 AIJ33081.1 pat pat dapC dapC dapD_1 dapD_1 aroP aroP AIJ33258.1 AIJ33258.1 dapD_2 dapD_2 AIJ33260.1 AIJ33260.1 AIJ33261.1 AIJ33261.1 crtQ crtQ lysA lysA hom hom thrB thrB serA serA trpB1 trpB1 hisG hisG hisE hisE aroB aroB aroK aroK aroC aroC sdaB sdaB AIJ33706.1 AIJ33706.1 dapF dapF miaA miaA AIJ33739.1 AIJ33739.1 AIJ33740.1 AIJ33740.1 AIJ33741.1 AIJ33741.1 miaB miaB dapA_2 dapA_2 dapB dapB nrnA nrnA Pab Pab lgt lgt AIJ33842.1 AIJ33842.1 hisI hisI hisF hisF AIJ33846.1 AIJ33846.1 hisA hisA hisH hisH AIJ33849.1 AIJ33849.1 hisB hisB hisC hisC hisD hisD ilvA ilvA aroG aroG AIJ33941.1 AIJ33941.1 patB patB AIJ34064.1 AIJ34064.1 metB metB cysK1 cysK1 cysE cysE sseA_2 sseA_2 cysY cysY cysNC cysNC cysD cysD cysH cysH AIJ34297.1 AIJ34297.1 sir sir fprA fprA pheA pheA AIJ34537.1 AIJ34537.1 AIJ34507.1 AIJ34507.1 trpD trpD trpC_1 trpC_1 trpB trpB trpA trpA qcrA2 qcrA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metFMethylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (321 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa)
tyrCPrephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
lysCAspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (421 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa)
AIJ32731.1Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
metXHomoserine acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (382 aa)
metZHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
sseA_1Thiosulfate sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (423 aa)
HisNHistidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (375 aa)
cysQMFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AIJ33081.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (344 aa)
dapCN-succinyldiaminopimelate aminotransferase; Catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
dapD_12,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (321 aa)
aroPAmino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AIJ33258.1Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
dapD_2Succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AIJ33260.1Succinyl-diaminopimelate desuccinylase; Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
AIJ33261.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (269 aa)
crtQGlucosyl-3-phosphoglycerate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (447 aa)
homHomoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
serA3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
trpB1Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (447 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (350 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (165 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (409 aa)
sdaBSerine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (465 aa)
AIJ33706.1Fructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the inositol monophosphatase superfamily. (286 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (272 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (307 aa)
AIJ33739.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
AIJ33740.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
AIJ33741.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
miaB(dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (486 aa)
dapA_2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa)
nrnAExopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
PabAminobenzoate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (618 aa)
lgtDiacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (299 aa)
AIJ33842.1Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (121 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
AIJ33846.1Fructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
hisAPhosphoribosyl isomerase; Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa)
AIJ33849.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (58 aa)
hisBImidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
hisCHistidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (364 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (435 aa)
aroGPhospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II DAHP synthase family. (462 aa)
AIJ33941.1Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
patBAminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
AIJ34064.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
metBCystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
cysK1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
cysESerine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
sseA_2Sulfultransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
cysYHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
cysNCSulfate adenylyltransferase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (429 aa)
cysDSulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (260 aa)
AIJ34297.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (88 aa)
sirSulfite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (557 aa)
fprAPyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
pheAPrephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
AIJ34537.1Signal peptide protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (187 aa)
AIJ34507.1Anthranilate synthase component II; TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa)
trpC_1Indole-3-glycerol phosphate synthase; Monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (479 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (423 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (285 aa)
qcrA2Iron-sulfur protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
Your Current Organism:
Corynebacterium imitans
NCBI taxonomy Id: 156978
Other names: ATCC 700354, C. imitans, CCUG 36877, CIP 105130, Corynebacterium sp. 2023, DSM 44264, IFO 16163, JCM 10386, NBRC 100416, NBRC 16163, NCTC 13015
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