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leuA leuA lpd lpd sdhC sdhC sdhA sdhA frdB frdB ppc_1 ppc_1 icd icd lpdA lpdA prpD prpD prpB prpB prpC2 prpC2 cfiB cfiB AIJ32934.1 AIJ32934.1 accE accE accD5_1 accD5_1 AIJ32950.1 AIJ32950.1 pycB pycB accB accB accBC2 accBC2 gabD1_1 gabD1_1 gltA gltA NagK NagK gabD2_1 gabD2_1 aspA aspA kgd kgd ldh ldh ilvD ilvD ilvB ilvB ilvH ilvH ilvC ilvC leuB leuB leuC leuC leuD leuD pflAN pflAN pflAC pflAC pflB pflB acnA acnA gabD2 gabD2 mqo mqo acyP acyP ilvE ilvE AIJ33919.1 AIJ33919.1 aceF aceF gcvP gcvP gcvT gcvT gcvH gcvH lipB lipB lipA lipA AIJ33926.1 AIJ33926.1 yjjP yjjP aceE aceE AIJ33965.1 AIJ33965.1 mdh mdh scpC scpC ackA ackA eutD eutD pqo pqo thcA thcA AIJ34308.1 AIJ34308.1 pckG pckG aldA aldA adhT adhT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (611 aa)
lpdDihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
sdhCSuccinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (689 aa)
frdBSuccinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
ppc_1Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (882 aa)
icdIsocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (724 aa)
lpdAFlavoprotein disulfide reductase; Catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
prpD2-methylcitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (306 aa)
prpC2Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
cfiBPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1140 aa)
AIJ32934.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
accEHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (71 aa)
accD5_1acyl-CoA carboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (504 aa)
AIJ32950.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (532 aa)
pycBPyruvate carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
accBacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (180 aa)
accBC2acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (458 aa)
gabD1_1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
gltACitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (431 aa)
NagK2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
gabD2_1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (489 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1247 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (612 aa)
ilvBAcetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (621 aa)
ilvHAcetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (338 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa)
pflANPyruvate formate lyase-activating protein; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (291 aa)
pflACFormate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (83 aa)
pflBFormate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (703 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (930 aa)
gabD2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
mqoMalate:quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
acyPAcylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (100 aa)
ilvECatalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (368 aa)
AIJ33919.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
aceFPyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (694 aa)
gcvPGlycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvP family. (944 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (357 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
lipBLipoate--protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (262 aa)
lipARadical SAM protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (347 aa)
AIJ33926.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
yjjPHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
aceEPyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (919 aa)
AIJ33965.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (324 aa)
scpCacetyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
eutDPhosphotransacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
pqoPyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (589 aa)
thcAAldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (506 aa)
AIJ34308.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (608 aa)
aldAAldehyde dehydrogenase; NAD-linked; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (477 aa)
adhTNADPH:quinone dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
Your Current Organism:
Corynebacterium imitans
NCBI taxonomy Id: 156978
Other names: ATCC 700354, C. imitans, CCUG 36877, CIP 105130, Corynebacterium sp. 2023, DSM 44264, IFO 16163, JCM 10386, NBRC 100416, NBRC 16163, NCTC 13015
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