STRINGSTRING
SEB45280.1 SEB45280.1 SEB46431.1 SEB46431.1 tdk tdk SEB50262.1 SEB50262.1 SEB55381.1 SEB55381.1 dcd dcd SEB57649.1 SEB57649.1 SEB63434.1 SEB63434.1 SEB72116.1 SEB72116.1 thyA thyA SEB76788.1 SEB76788.1 groS groS SEB83505.1 SEB83505.1 SEB86824.1 SEB86824.1 SEB89852.1 SEB89852.1 SEB94140.1 SEB94140.1 SEB96885.1 SEB96885.1 ndk ndk dut dut pyrD pyrD SEC16228.1 SEC16228.1 carB carB carA carA SEC16349.1 SEC16349.1 pyrC pyrC pyrB pyrB pyrR pyrR SEC18153.1 SEC18153.1 SEC20957.1 SEC20957.1 nrdF nrdF SEC21136.1 SEC21136.1 nrdI nrdI nrdR nrdR SEC24824.1 SEC24824.1 SEC25083.1 SEC25083.1 SEC25229.1 SEC25229.1 cmk cmk pyrG pyrG SEC35729.1 SEC35729.1 pyrH pyrH SEC41097.1 SEC41097.1 SEC41280.1 SEC41280.1 SEC46646.1 SEC46646.1 SEC46684.1 SEC46684.1 SEC50950.1 SEC50950.1 SEC51918.1 SEC51918.1 SEC54564.1 SEC54564.1 tmk tmk SEC81556.1 SEC81556.1 upp upp tadA tadA tgt tgt SEC84844.1 SEC84844.1 pyrE pyrE SEC90799.1 SEC90799.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEB45280.1MFS transporter, MHS family, metabolite:H+ symporter. (470 aa)
SEB46431.1MFS transporter, MHS family, alpha-ketoglutarate permease. (437 aa)
tdkThymidine kinase. (208 aa)
SEB50262.13-hydroxypropanoate dehydrogenase. (201 aa)
SEB55381.1Na+/melibiose symporter. (421 aa)
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
SEB57649.1MFS transporter, UMF1 family. (459 aa)
SEB63434.1Na+/melibiose symporter. (441 aa)
SEB72116.1Hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (267 aa)
SEB76788.12',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase; Belongs to the 5'-nucleotidase family. (608 aa)
groSChaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (98 aa)
SEB83505.1Hypothetical protein; Belongs to the LOG family. (258 aa)
SEB86824.1Hypothetical protein. (320 aa)
SEB89852.1N-carbamoyl-L-amino-acid hydrolase. (410 aa)
SEB94140.1Putative hydrolase of the HAD superfamily. (284 aa)
SEB96885.1Major Facilitator Superfamily protein. (439 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (157 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (355 aa)
SEC16228.1Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (282 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1100 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (398 aa)
SEC16349.1Hypothetical protein. (164 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (442 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (336 aa)
pyrRPyrimidine operon attenuation protein / uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (194 aa)
SEC18153.1Predicted arabinose efflux permease, MFS family. (478 aa)
SEC20957.1Protein of unknown function. (494 aa)
nrdFRibonucleoside-diphosphate reductase class Ib beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (325 aa)
SEC21136.1Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (713 aa)
nrdIProtein involved in ribonucleotide reduction; Probably involved in ribonucleotide reductase function. (166 aa)
nrdRTranscriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa)
SEC24824.1Cytosine/adenosine deaminase. (408 aa)
SEC25083.1Nicotinamidase-related amidase. (207 aa)
SEC25229.1Cytosine deaminase. (358 aa)
cmkCytidylate kinase. (267 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (569 aa)
SEC35729.1MFS transporter, DHA2 family, multidrug resistance protein. (481 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa)
SEC41097.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
SEC41280.1LysM repeat-containing protein. (252 aa)
SEC46646.1Thymidine phosphorylase. (442 aa)
SEC46684.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (156 aa)
SEC50950.15-methylcytosine-specific restriction endonuclease McrA. (166 aa)
SEC51918.1MFS transporter, DHA2 family, multidrug resistance protein. (520 aa)
SEC54564.1HNH endonuclease; Manually curated. (100 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (232 aa)
SEC81556.15'-nucleotidase. (1520 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (215 aa)
tadAtRNA(adenine34) deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (168 aa)
tgttRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (426 aa)
SEC84844.1MFS transporter, MHS family, alpha-ketoglutarate permease; Manually curated. (437 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (189 aa)
SEC90799.1HNH endonuclease; Manually curated. (100 aa)
Your Current Organism:
Arthrobacter woluwensis
NCBI taxonomy Id: 156980
Other names: A. woluwensis, ATCC 700220, CCUG 36790, CIP 104908, DSM 10495, JCM 11679, NBRC 107840
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.