(34 nodes) Mixed, incl. Gamma-secretase complex, and Notch signaling pathway network (Trichobilharzia regenti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRE_LOCUS1348	Uncharacterized protein. (312 aa)
	TRE_LOCUS764	Uncharacterized protein. (69 aa)
	TRE_LOCUS1912	ANK_REP_REGION domain-containing protein. (492 aa)
	TRE_LOCUS2171	Uncharacterized protein. (330 aa)
	TRE_LOCUS2430	Uncharacterized protein. (386 aa)
	TRE_LOCUS2468	Uncharacterized protein. (448 aa)
	TRE_LOCUS3224	Uncharacterized protein. (691 aa)
	A0A183VS46	LNR domain-containing protein. (364 aa)
	TRE_LOCUS3484	Uncharacterized protein. (1024 aa)
	TRE_LOCUS4172	Uncharacterized protein. (387 aa)
	TRE_LOCUS4240	PID domain-containing protein. (197 aa)
	A0A183W3C9	Disintegrin domain-containing protein. (88 aa)
	TRE_LOCUS21825	CA domain-containing protein. (217 aa)
	TRE_LOCUS7882	Uncharacterized protein. (197 aa)
	TRE_LOCUS7884	Uncharacterized protein. (394 aa)
	TRE_LOCUS10896	Phtf-FEM1B_bdg domain-containing protein. (352 aa)
	TRE_LOCUS12136	Uncharacterized protein. (501 aa)
	TRE_LOCUS12482	Uncharacterized protein. (300 aa)
	A0A183WKG6	CA domain-containing protein. (184 aa)
	A0A183WLJ2	Uncharacterized protein. (412 aa)
	TRE_LOCUS13499	Uncharacterized protein. (226 aa)
	TRE_LOCUS16117	Uncharacterized protein. (127 aa)
	A0A183WWK1	Ncstrn_small domain-containing protein. (266 aa)
	TRE_LOCUS16750	Uncharacterized protein. (114 aa)
	TRE_LOCUS16987	Uncharacterized protein. (103 aa)
	TRE_LOCUS17121	Uncharacterized protein. (98 aa)
	A0A183WYJ5	Uncharacterized protein. (89 aa)
	TRE_LOCUS18189	Uncharacterized protein. (75 aa)
	A0A183X2R3	Uncharacterized protein. (63 aa)
	TRE_LOCUS19010	Uncharacterized protein. (96 aa)
	A0A183X3X0	Uncharacterized protein. (156 aa)
	TRE_LOCUS19842	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (151 aa)
	A0A183X736	Uncharacterized protein. (91 aa)
	TRE_LOCUS20572	EGF_CA domain-containing protein. (82 aa)

Your Current Organism:

Trichobilharzia regenti

NCBI taxonomy Id: 157069
Other names: T. regenti, bird nasal schistosome

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A183VS46	A0A183W3C9	A0A183VS46	A0A183W3C9	LNR domain-containing protein.	Disintegrin domain-containing protein.	0.831
A0A183VS46	A0A183WKG6	A0A183VS46	A0A183WKG6	LNR domain-containing protein.	CA domain-containing protein.	0.408
A0A183VS46	A0A183WLJ2	A0A183VS46	A0A183WLJ2	LNR domain-containing protein.	Uncharacterized protein.	0.545
A0A183VS46	A0A183WWK1	A0A183VS46	A0A183WWK1	LNR domain-containing protein.	Ncstrn_small domain-containing protein.	0.915
A0A183VS46	A0A183WYJ5	A0A183VS46	A0A183WYJ5	LNR domain-containing protein.	Uncharacterized protein.	0.890
A0A183VS46	A0A183X2R3	A0A183VS46	A0A183X2R3	LNR domain-containing protein.	Uncharacterized protein.	0.868
A0A183VS46	A0A183X3X0	A0A183VS46	A0A183X3X0	LNR domain-containing protein.	Uncharacterized protein.	0.545
A0A183VS46	TRE_LOCUS10896	A0A183VS46	A0A183WFJ4	LNR domain-containing protein.	Phtf-FEM1B_bdg domain-containing protein.	0.545
A0A183VS46	TRE_LOCUS12482	A0A183VS46	A0A183WK27	LNR domain-containing protein.	Uncharacterized protein.	0.943
A0A183VS46	TRE_LOCUS1348	A0A183VS46	A0A183VJ04	LNR domain-containing protein.	Uncharacterized protein.	0.408
A0A183VS46	TRE_LOCUS16117	A0A183VS46	A0A183WVG5	LNR domain-containing protein.	Uncharacterized protein.	0.868
A0A183VS46	TRE_LOCUS16987	A0A183VS46	A0A183WXY1	LNR domain-containing protein.	Uncharacterized protein.	0.834
A0A183VS46	TRE_LOCUS17121	A0A183VS46	A0A183WYB8	LNR domain-containing protein.	Uncharacterized protein.	0.898
A0A183VS46	TRE_LOCUS18189	A0A183VS46	A0A183X1D5	LNR domain-containing protein.	Uncharacterized protein.	0.890
A0A183VS46	TRE_LOCUS19010	A0A183VS46	A0A183X3Q7	LNR domain-containing protein.	Uncharacterized protein.	0.689
A0A183VS46	TRE_LOCUS19842	A0A183VS46	A0A183X638	LNR domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.890
A0A183VS46	TRE_LOCUS21825	A0A183VS46	A0A183W483	LNR domain-containing protein.	CA domain-containing protein.	0.408
A0A183VS46	TRE_LOCUS2468	A0A183VS46	A0A183VPR2	LNR domain-containing protein.	Uncharacterized protein.	0.408
A0A183VS46	TRE_LOCUS3224	A0A183VS46	A0A183VRW8	LNR domain-containing protein.	Uncharacterized protein.	0.408
A0A183VS46	TRE_LOCUS4240	A0A183VS46	A0A183VUT4	LNR domain-containing protein.	PID domain-containing protein.	0.868