(55 nodes) Notch signaling pathway network (Trichobilharzia regenti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRE_LOCUS19842	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (151 aa)
	TRE_LOCUS197	Uncharacterized protein. (990 aa)
	TRE_LOCUS214	TAZ-type domain-containing protein. (191 aa)
	TRE_LOCUS244	Uncharacterized protein. (223 aa)
	TRE_LOCUS249	PDZ domain-containing protein. (95 aa)
	TRE_LOCUS764	Uncharacterized protein. (69 aa)
	TRE_LOCUS849	PCAF_N domain-containing protein. (258 aa)
	TRE_LOCUS872	KIX domain-containing protein. (247 aa)
	TRE_LOCUS1912	ANK_REP_REGION domain-containing protein. (492 aa)
	TRE_LOCUS1939	Uncharacterized protein. (136 aa)
	TRE_LOCUS2430	Uncharacterized protein. (386 aa)
	TRE_LOCUS2521	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (292 aa)
	TRE_LOCUS2535	Uncharacterized protein. (579 aa)
	TRE_LOCUS2650	AXH domain-containing protein. (446 aa)
	TRE_LOCUS3000	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (251 aa)
	A0A183VS46	LNR domain-containing protein. (364 aa)
	TRE_LOCUS3348	Uncharacterized protein. (241 aa)
	TRE_LOCUS3759	Uncharacterized protein. (472 aa)
	TRE_LOCUS3879	Uncharacterized protein. (326 aa)
	TRE_LOCUS4172	Uncharacterized protein. (387 aa)
	TRE_LOCUS4240	PID domain-containing protein. (197 aa)
	TRE_LOCUS5497	DDT domain-containing protein. (750 aa)
	TRE_LOCUS6770	DUF4205 domain-containing protein. (359 aa)
	TRE_LOCUS7047	Uncharacterized protein. (171 aa)
	A0A183W3C9	Disintegrin domain-containing protein. (88 aa)
	TRE_LOCUS21980	CBP/p300-type HAT domain-containing protein. (247 aa)
	TRE_LOCUS22025	WD_REPEATS_REGION domain-containing protein. (149 aa)
	A0A183W7U2	DEP domain-containing protein. (518 aa)
	TRE_LOCUS8413	BHLH domain-containing protein. (282 aa)
	TRE_LOCUS8416	Uncharacterized protein. (124 aa)
	TRE_LOCUS8569	Uncharacterized protein. (517 aa)
	A0A183WAY5	DEP domain-containing protein. (308 aa)
	TRE_LOCUS10002	Orange domain-containing protein. (510 aa)
	TRE_LOCUS11283	Uncharacterized protein. (302 aa)
	A0A183WHV9	2-Hacid_dh_C domain-containing protein. (337 aa)
	A0A183WJE0	Uncharacterized protein. (173 aa)
	TRE_LOCUS12482	Uncharacterized protein. (300 aa)
	TRE_LOCUS12573	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (398 aa)
	TRE_LOCUS14235	Uncharacterized protein. (463 aa)
	TRE_LOCUS14292	TLE_N domain-containing protein. (315 aa)
	A0A183WQR0	Uncharacterized protein. (194 aa)
	A0A183WR34	Hist_deacetyl domain-containing protein. (96 aa)
	TRE_LOCUS14681	N-acetyltransferase domain-containing protein. (180 aa)
	TRE_LOCUS20230	Uncharacterized protein. (167 aa)
	A0A183WT65	WD_REPEATS_REGION domain-containing protein. (104 aa)
	A0A183WUB2	Uncharacterized protein. (87 aa)
	TRE_LOCUS16117	Uncharacterized protein. (127 aa)
	A0A183WWK1	Ncstrn_small domain-containing protein. (266 aa)
	TRE_LOCUS17121	Uncharacterized protein. (98 aa)
	A0A183WYJ5	Uncharacterized protein. (89 aa)
	TRE_LOCUS18189	Uncharacterized protein. (75 aa)
	TRE_LOCUS18192	DIX domain-containing protein. (141 aa)
	TRE_LOCUS18491	Uncharacterized protein. (193 aa)
	A0A183X2R3	Uncharacterized protein. (63 aa)
	TRE_LOCUS19010	Uncharacterized protein. (96 aa)

Your Current Organism:

Trichobilharzia regenti

NCBI taxonomy Id: 157069
Other names: T. regenti, bird nasal schistosome

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A183VS46	A0A183W3C9	A0A183VS46	A0A183W3C9	LNR domain-containing protein.	Disintegrin domain-containing protein.	0.831
A0A183VS46	A0A183W7U2	A0A183VS46	A0A183W7U2	LNR domain-containing protein.	DEP domain-containing protein.	0.859
A0A183VS46	A0A183WAY5	A0A183VS46	A0A183WAY5	LNR domain-containing protein.	DEP domain-containing protein.	0.859
A0A183VS46	A0A183WQR0	A0A183VS46	A0A183WQR0	LNR domain-containing protein.	Uncharacterized protein.	0.831
A0A183VS46	A0A183WUB2	A0A183VS46	A0A183WUB2	LNR domain-containing protein.	Uncharacterized protein.	0.415
A0A183VS46	A0A183WWK1	A0A183VS46	A0A183WWK1	LNR domain-containing protein.	Ncstrn_small domain-containing protein.	0.915
A0A183VS46	A0A183WYJ5	A0A183VS46	A0A183WYJ5	LNR domain-containing protein.	Uncharacterized protein.	0.890
A0A183VS46	A0A183X2R3	A0A183VS46	A0A183X2R3	LNR domain-containing protein.	Uncharacterized protein.	0.868
A0A183VS46	TRE_LOCUS12482	A0A183VS46	A0A183WK27	LNR domain-containing protein.	Uncharacterized protein.	0.943
A0A183VS46	TRE_LOCUS14235	A0A183VS46	A0A183WQ31	LNR domain-containing protein.	Uncharacterized protein.	0.455
A0A183VS46	TRE_LOCUS14681	A0A183VS46	A0A183WRC8	LNR domain-containing protein.	N-acetyltransferase domain-containing protein.	0.415
A0A183VS46	TRE_LOCUS16117	A0A183VS46	A0A183WVG5	LNR domain-containing protein.	Uncharacterized protein.	0.868
A0A183VS46	TRE_LOCUS17121	A0A183VS46	A0A183WYB8	LNR domain-containing protein.	Uncharacterized protein.	0.898
A0A183VS46	TRE_LOCUS18189	A0A183VS46	A0A183X1D5	LNR domain-containing protein.	Uncharacterized protein.	0.890
A0A183VS46	TRE_LOCUS18192	A0A183VS46	A0A183X1E0	LNR domain-containing protein.	DIX domain-containing protein.	0.852
A0A183VS46	TRE_LOCUS19010	A0A183VS46	A0A183X3Q7	LNR domain-containing protein.	Uncharacterized protein.	0.689
A0A183VS46	TRE_LOCUS197	A0A183VS46	A0A183VJL3	LNR domain-containing protein.	Uncharacterized protein.	0.493
A0A183VS46	TRE_LOCUS19842	A0A183VS46	A0A183X638	LNR domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.890
A0A183VS46	TRE_LOCUS20230	A0A183VS46	A0A183X777	LNR domain-containing protein.	Uncharacterized protein.	0.831
A0A183VS46	TRE_LOCUS214	A0A183VS46	A0A183VJN0	LNR domain-containing protein.	TAZ-type domain-containing protein.	0.482