STRINGSTRING
APE08030.1 APE08030.1 APE08035.1 APE08035.1 sbcD sbcD APE12001.1 APE12001.1 APE12037.1 APE12037.1 APE08721.1 APE08721.1 recA recA APE08945.1 APE08945.1 priA priA APE09290.1 APE09290.1 polA polA APE09543.1 APE09543.1 APE12193.1 APE12193.1 dnaG dnaG APE09783.1 APE09783.1 APE09903.1 APE09903.1 APE09907.1 APE09907.1 APE12228.1 APE12228.1 dnaE2 dnaE2 APE10703.1 APE10703.1 APE10733.1 APE10733.1 APE11128.1 APE11128.1 APE11131.1 APE11131.1 BO226_19855 BO226_19855 APE11220.1 APE11220.1 APE11341.1 APE11341.1 dnaX dnaX topA topA APE11703.1 APE11703.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APE08030.1ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (792 aa)
APE08035.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa)
sbcDExonuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (392 aa)
APE12001.1ATP-dependent dsDNA exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (992 aa)
APE12037.13'-5' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
APE08721.1Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (737 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa)
APE08945.1Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (672 aa)
APE09290.1Flap endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (907 aa)
APE09543.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1178 aa)
APE12193.1Hypothetical protein; Contains 3'-5'exonuclease domain; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (631 aa)
APE09783.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
APE09903.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (714 aa)
APE09907.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1118 aa)
APE12228.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1108 aa)
dnaE2Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1083 aa)
APE10703.1Cytochrome; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cytochrome P450 family. (444 aa)
APE10733.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
APE11128.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (1035 aa)
APE11131.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
BO226_19855Transposase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
APE11220.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (394 aa)
APE11341.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (267 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (758 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (976 aa)
APE11703.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
Your Current Organism:
Rhodococcus sp. 2G
NCBI taxonomy Id: 1570939
Other names: R. sp. 2G
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.