STRINGSTRING
APE11983.1 APE11983.1 purH purH glyA glyA APE08236.1 APE08236.1 APE08238.1 APE08238.1 APE08327.1 APE08327.1 apt apt APE08947.1 APE08947.1 pyrR pyrR pyrB pyrB pyrC pyrC APE08972.1 APE08972.1 carA carA carB carB pyrF pyrF gmk gmk pyrD pyrD APE09596.1 APE09596.1 purE purE purK purK APE10002.1 APE10002.1 APE10003.1 APE10003.1 APE12246.1 APE12246.1 APE10004.1 APE10004.1 APE10005.1 APE10005.1 upp upp add add APE10013.1 APE10013.1 APE10014.1 APE10014.1 folD folD guaA guaA APE10052.1 APE10052.1 guaB guaB purU purU purA purA pyrE pyrE APE10445.1 APE10445.1 APE12308.1 APE12308.1 APE10456.1 APE10456.1 APE11366.1 APE11366.1 APE11576.1 APE11576.1 APE11714.1 APE11714.1 APE12488.1 APE12488.1 tilS tilS APE11716.1 APE11716.1 purD purD APE11891.1 APE11891.1 purC purC purS purS purQ purQ purL purL purF purF purM purM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APE11983.1Phosphoribosylglycinamide formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
purHBifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
APE08236.1Allantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
APE08238.1Uracil permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
APE08327.1Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (310 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (185 aa)
APE08947.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
pyrRBifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (205 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (437 aa)
APE08972.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (394 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1114 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (280 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (183 aa)
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (356 aa)
APE09596.1Carbohydrate kinase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (157 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (424 aa)
APE10002.1N-acyl-L-amino acid amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
APE10003.1Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M20A family. (386 aa)
APE12246.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
APE10004.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (270 aa)
APE10005.1Phosphomannomutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (499 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (361 aa)
APE10013.1Thymidine phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
APE10014.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
guaAGlutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (524 aa)
APE10052.1Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (507 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (295 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa)
APE10445.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
APE12308.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the globin family. (386 aa)
APE10456.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
APE11366.1Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
APE11576.1Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (565 aa)
APE11714.1D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
APE12488.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
tilStRNA lysidine(34) synthetase TilS; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (349 aa)
APE11716.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (417 aa)
APE11891.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (473 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (295 aa)
purSPhosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (81 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (225 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (759 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (527 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
Your Current Organism:
Rhodococcus sp. 2G
NCBI taxonomy Id: 1570939
Other names: R. sp. 2G
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