STRINGSTRING
arc arc APE09279.1 APE09279.1 pup pup prcB prcB prcA prcA APE09283.1 APE09283.1 pafA pafA APE09285.1 APE09285.1 APE09286.1 APE09286.1 APE10804.1 APE10804.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arcProteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. (589 aa)
APE09279.1Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
pupUbiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. (63 aa)
prcBProteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. (284 aa)
prcAProteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. (270 aa)
APE09283.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (532 aa)
pafAPup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (447 aa)
APE09285.1WYL domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
APE09286.1Protein pafC; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
APE10804.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
Your Current Organism:
Rhodococcus sp. 2G
NCBI taxonomy Id: 1570939
Other names: R. sp. 2G
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