(19 nodes) Mixed, incl. acetyl-CoA metabolic process, and Thiamin diphosphate-binding fold network (Rhodococcus sp. 2G)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	prpE	Catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (630 aa)
	APE08315.1	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (597 aa)
	APE08478.1	Aldehyde dehydrogenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (474 aa)
	APE12076.1	propionyl-CoA--succinate CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
	APE08793.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
	APE12093.1	GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (884 aa)
	APE09130.1	NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (495 aa)
	APE12130.1	FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (980 aa)
	APE09131.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (492 aa)
	BO226_07920	Hypothetical protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
	ackA	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (404 aa)
	APE12296.1	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (694 aa)
	APE12331.1	Indolepyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1152 aa)
	APE10634.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (482 aa)
	APE10677.1	2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
	APE10678.1	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (644 aa)
	APE10841.1	FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (925 aa)
	APE11262.1	Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
	acsA	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (643 aa)

Your Current Organism:

Rhodococcus sp. 2G

NCBI taxonomy Id: 1570939
Other names: R. sp. 2G

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APE08315.1	APE08478.1	BO226_03005	BO226_03965	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Aldehyde dehydrogenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.878
APE08315.1	APE08793.1	BO226_03005	BO226_05790	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.874
APE08315.1	APE09130.1	BO226_03005	BO226_07795	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.402
APE08315.1	APE09131.1	BO226_03005	BO226_07805	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.402
APE08315.1	APE10634.1	BO226_03005	BO226_16695	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.860
APE08315.1	APE10677.1	BO226_03005	BO226_16945	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.845
APE08315.1	APE10678.1	BO226_03005	BO226_16950	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.885
APE08315.1	APE10841.1	BO226_03005	BO226_17895	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.682
APE08315.1	APE12093.1	BO226_03005	BO226_06300	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.674
APE08315.1	APE12130.1	BO226_03005	BO226_07800	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.691
APE08315.1	APE12296.1	BO226_03005	BO226_15160	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.	0.805
APE08315.1	APE12331.1	BO226_03005	BO226_16335	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Indolepyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.658
APE08315.1	BO226_07920	BO226_03005	BO226_07920	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Hypothetical protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.904
APE08315.1	ackA	BO226_03005	BO226_15155	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.933
APE08315.1	acsA	BO226_03005	BO226_22920	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.877
APE08478.1	APE08315.1	BO226_03965	BO226_03005	Aldehyde dehydrogenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Thiamine pyrophosphate-requiring protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family.	0.878
APE08478.1	APE08793.1	BO226_03965	BO226_05790	Aldehyde dehydrogenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
APE08478.1	APE09131.1	BO226_03965	BO226_07805	Aldehyde dehydrogenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.405
APE08478.1	APE10634.1	BO226_03965	BO226_16695	Aldehyde dehydrogenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.635
APE08478.1	APE10678.1	BO226_03965	BO226_16950	Aldehyde dehydrogenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.569