STRINGSTRING
radA radA APE07895.1 APE07895.1 APE08030.1 APE08030.1 APE08173.1 APE08173.1 recC recC recB recB recD recD APE08517.1 APE08517.1 APE08576.1 APE08576.1 APE11836.1 APE11836.1 APE08622.1 APE08622.1 recG recG recA recA APE08898.1 APE08898.1 ruvA ruvA ruvB ruvB priA priA APE12121.1 APE12121.1 APE09423.1 APE09423.1 APE09903.1 APE09903.1 APE09907.1 APE09907.1 APE12228.1 APE12228.1 APE10346.1 APE10346.1 APE11128.1 APE11128.1 gyrB gyrB gyrA gyrA APE11341.1 APE11341.1 APE11483.1 APE11483.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (463 aa)
APE07895.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (552 aa)
APE08030.1ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (792 aa)
APE08173.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (659 aa)
recCExodeoxyribonuclease V subunit gamma; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (1097 aa)
recBAAA family ATPase; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme de [...] (1110 aa)
recDExodeoxyribonuclease V subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (625 aa)
APE08517.1ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (935 aa)
APE08576.1ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (677 aa)
APE11836.1GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
APE08622.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (349 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (763 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa)
APE08898.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (198 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (398 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (672 aa)
APE12121.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1072 aa)
APE09423.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (772 aa)
APE09903.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (714 aa)
APE09907.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1118 aa)
APE12228.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1108 aa)
APE10346.1Nuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (1164 aa)
APE11128.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (1035 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (678 aa)
gyrASignal protein; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (834 aa)
APE11341.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (267 aa)
APE11483.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (59 aa)
Your Current Organism:
Rhodococcus sp. 2G
NCBI taxonomy Id: 1570939
Other names: R. sp. 2G
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