STRINGSTRING
purF purF APE08006.1 APE08006.1 ispH ispH APE08251.1 APE08251.1 APE08267.1 APE08267.1 fbiC fbiC APE08271.1 APE08271.1 APE12025.1 APE12025.1 acnA acnA APE08635.1 APE08635.1 APE08640.1 APE08640.1 APE08641.1 APE08641.1 APE08642.1 APE08642.1 APE08648.1 APE08648.1 APE08692.1 APE08692.1 APE12072.1 APE12072.1 rlmN rlmN ispG ispG APE08822.1 APE08822.1 miaB miaB APE08938.1 APE08938.1 APE09026.1 APE09026.1 APE09027.1 APE09027.1 APE09032.1 APE09032.1 APE09099.1 APE09099.1 APE12130.1 APE12130.1 APE12133.1 APE12133.1 APE09183.1 APE09183.1 whiB whiB nuoI nuoI nuoH nuoH APE09467.1 APE09467.1 APE12171.1 APE12171.1 nuoB nuoB nadA nadA bioB bioB APE09522.1 APE09522.1 APE09590.1 APE09590.1 APE09597.1 APE09597.1 lipA lipA APE12206.1 APE12206.1 APE09765.1 APE09765.1 cysH cysH leuC leuC ilvD ilvD APE09832.1 APE09832.1 APE09862.1 APE09862.1 moaA moaA whiB-2 whiB-2 APE09916.1 APE09916.1 APE09917.1 APE09917.1 whiB-3 whiB-3 APE09931.1 APE09931.1 BO226_12600 BO226_12600 whiB-4 whiB-4 APE10018.1 APE10018.1 whiB-5 whiB-5 APE10142.1 APE10142.1 APE12264.1 APE12264.1 APE10154.1 APE10154.1 APE10180.1 APE10180.1 APE10181.1 APE10181.1 APE10292.1 APE10292.1 APE10299.1 APE10299.1 APE10322.1 APE10322.1 BO226_15315 BO226_15315 APE10469.1 APE10469.1 APE10477.1 APE10477.1 APE10505.1 APE10505.1 APE10532.1 APE10532.1 APE12325.1 APE12325.1 APE12331.1 APE12331.1 whiB-6 whiB-6 APE10706.1 APE10706.1 whiB-7 whiB-7 APE10726.1 APE10726.1 APE10807.1 APE10807.1 APE10841.1 APE10841.1 APE10860.1 APE10860.1 APE10907.1 APE10907.1 APE10966.1 APE10966.1 APE11106.1 APE11106.1 APE11205.1 APE11205.1 APE11278.1 APE11278.1 gltD gltD APE11345.1 APE11345.1 APE11346.1 APE11346.1 APE11385.1 APE11385.1 APE11387.1 APE11387.1 APE11388.1 APE11388.1 thiC thiC APE11519.1 APE11519.1 APE11527.1 APE11527.1 ilvD-2 ilvD-2 APE11619.1 APE11619.1 APE11621.1 APE11621.1 APE12473.1 APE12473.1 whiB-8 whiB-8 nth nth APE11741.1 APE11741.1 APE11777.1 APE11777.1 APE12499.1 APE12499.1 APE11818.1 APE11818.1 APE11854.1 APE11854.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (527 aa)
APE08006.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (332 aa)
APE08251.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (565 aa)
APE08267.1uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
fbiC7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (865 aa)
APE08271.1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa)
APE12025.1Sodium:proton antiporter; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (377 aa)
acnAAconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (932 aa)
APE08635.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
APE08640.14Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
APE08641.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (897 aa)
APE08642.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
APE08648.1Carbon monoxide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
APE08692.1FMN-binding glutamate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (442 aa)
APE12072.1Protein glxC; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
rlmN23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (369 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (384 aa)
APE08822.1Nitrate reductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1231 aa)
miaBtRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (509 aa)
APE08938.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
APE09026.1SUF system NifU family Fe-S cluster assembly protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
APE09027.1Metal-sulfur cluster biosynthetic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
APE09032.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (934 aa)
APE09099.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (207 aa)
APE12130.1FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (980 aa)
APE12133.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
APE09183.1Iron-sulfur cluster-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
whiBWhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (87 aa)
nuoINADH-quinone oxidoreductase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (181 aa)
nuoHNADH-quinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (433 aa)
APE09467.1NADH-quinone oxidoreductase subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (822 aa)
APE12171.1NADH oxidoreductase (quinone) subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (435 aa)
nuoBNADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
nadAQuinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (343 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa)
APE09522.1Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
APE09590.1Menaquinol-cytochrome C reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
APE09597.1Iron-sulfur cluster insertion protein ErpA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family. (116 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (336 aa)
APE12206.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (415 aa)
APE09765.1Sulfite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (571 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (242 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (475 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (613 aa)
APE09832.1Cysteine desulfurase NifS; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
APE09862.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
moaACyclic pyranopterin phosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (352 aa)
whiB-2Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa)
APE09916.1Nitrite reductase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
APE09917.1Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (838 aa)
whiB-3WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa)
APE09931.1Mycothiol system anti-sigma-R factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
BO226_12600acyl-CoA desaturase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
whiB-4Transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (115 aa)
APE10018.1Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
whiB-5WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (97 aa)
APE10142.1Mycofactocin radical SAM maturase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
APE12264.1Mycofactocin system protein MftB; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
APE10154.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
APE10180.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
APE10181.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (558 aa)
APE10292.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
APE10299.1FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
APE10322.1stearoyl-CoA 9-desaturase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
BO226_15315ABC transporter ATP-binding protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
APE10469.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
APE10477.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (106 aa)
APE10505.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
APE10532.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1062 aa)
APE12325.1Cytochrome; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cytochrome P450 family. (786 aa)
APE12331.1Indolepyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1152 aa)
whiB-6Transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (97 aa)
APE10706.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (62 aa)
whiB-7WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (99 aa)
APE10726.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (558 aa)
APE10807.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (63 aa)
APE10841.1FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (925 aa)
APE10860.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
APE10907.1uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
APE10966.1[Fe-S]-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
APE11106.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
APE11205.1Reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (1351 aa)
APE11278.1Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1531 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
APE11345.1FMN-binding glutamate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (518 aa)
APE11346.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (791 aa)
APE11385.1Benzene 1,2-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
APE11387.1Benzoate 1,2-dioxygenase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
APE11388.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (594 aa)
APE11519.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
APE11527.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
ilvD-2Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (565 aa)
APE11619.1DUF2231 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
APE11621.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
APE12473.12Fe-2S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
whiB-8Transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (107 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (264 aa)
APE11741.1Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
APE11777.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
APE12499.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
APE11818.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
APE11854.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (61 aa)
Your Current Organism:
Rhodococcus sp. 2G
NCBI taxonomy Id: 1570939
Other names: R. sp. 2G
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