STRINGSTRING
AKN68873.1 AKN68873.1 AKN68874.1 AKN68874.1 AKN68882.1 AKN68882.1 AKN69235.1 AKN69235.1 aspA aspA AKN69305.1 AKN69305.1 AKN69353.1 AKN69353.1 AKN69568.1 AKN69568.1 AKN69738.1 AKN69738.1 ackA ackA AKN69873.1 AKN69873.1 AKN70138.1 AKN70138.1 AKN70256.1 AKN70256.1 AKN70257.1 AKN70257.1 AKN70258.1 AKN70258.1 AKN70267.1 AKN70267.1 AKN70268.1 AKN70268.1 AKN70269.1 AKN70269.1 AKN70313.1 AKN70313.1 AKN70834.1 AKN70834.1 AKN70835.1 AKN70835.1 AKN70836.1 AKN70836.1 AKN70837.1 AKN70837.1 AKN70967.1 AKN70967.1 AKN75349.1 AKN75349.1 AKN70999.1 AKN70999.1 acsA acsA pckG pckG AKN71818.1 AKN71818.1 kgd kgd acnA acnA AKN72228.1 AKN72228.1 AKN72271.1 AKN72271.1 AKN72385.1 AKN72385.1 AKN72386.1 AKN72386.1 ppc ppc AKN75542.1 AKN75542.1 mdh mdh sucD sucD sucC sucC gabD2 gabD2 AKN73006.1 AKN73006.1 AKN73770.1 AKN73770.1 AKN74099.1 AKN74099.1 AKN74125.1 AKN74125.1 sdhA-2 sdhA-2 AKN74127.1 AKN74127.1 AKN75759.1 AKN75759.1 AKN74507.1 AKN74507.1 AKN74753.1 AKN74753.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKN68873.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AKN68874.1Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (608 aa)
AKN68882.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AKN69235.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (556 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
AKN69305.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
AKN69353.1Flavoprotein disulfide reductase; Catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
AKN69568.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
AKN69738.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (906 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
AKN69873.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (700 aa)
AKN70138.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (493 aa)
AKN70256.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
AKN70257.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AKN70258.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
AKN70267.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
AKN70268.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AKN70269.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AKN70313.1Carboxyvinyl-carboxyphosphonate phosphorylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
AKN70834.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
AKN70835.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
AKN70836.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
AKN70837.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
AKN70967.1pimeloyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (739 aa)
AKN75349.1Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (367 aa)
AKN70999.1Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
AKN71818.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1277 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
AKN72228.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AKN72271.1Carboxyvinyl-carboxyphosphonate phosphorylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
AKN72385.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (388 aa)
AKN72386.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (910 aa)
AKN75542.1Carboxyvinyl-carboxyphosphonate phosphorylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
gabD2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa)
AKN73006.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
AKN73770.1Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (541 aa)
AKN74099.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AKN74125.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
sdhA-2Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (649 aa)
AKN74127.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
AKN75759.1Dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
AKN74507.1CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (896 aa)
AKN74753.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
Your Current Organism:
Streptomyces sp. PBH53
NCBI taxonomy Id: 1577075
Other names: S. sp. PBH53
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