STRINGSTRING
AKN69235.1 AKN69235.1 aspA aspA AKN69568.1 AKN69568.1 AKN70313.1 AKN70313.1 AKN70834.1 AKN70834.1 AKN70835.1 AKN70835.1 AKN70836.1 AKN70836.1 AKN70837.1 AKN70837.1 AKN75349.1 AKN75349.1 AKN70999.1 AKN70999.1 AKN71818.1 AKN71818.1 acnA acnA AKN72385.1 AKN72385.1 AKN72386.1 AKN72386.1 AKN75542.1 AKN75542.1 mdh mdh sucD sucD sucC sucC gabD2 gabD2 AKN74125.1 AKN74125.1 sdhA-2 sdhA-2 AKN74127.1 AKN74127.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKN69235.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (556 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
AKN69568.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
AKN70313.1Carboxyvinyl-carboxyphosphonate phosphorylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
AKN70834.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
AKN70835.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
AKN70836.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
AKN70837.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
AKN75349.1Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (367 aa)
AKN70999.1Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AKN71818.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
AKN72385.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (388 aa)
AKN72386.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
AKN75542.1Carboxyvinyl-carboxyphosphonate phosphorylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
gabD2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa)
AKN74125.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
sdhA-2Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (649 aa)
AKN74127.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
Your Current Organism:
Streptomyces sp. PBH53
NCBI taxonomy Id: 1577075
Other names: S. sp. PBH53
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.