STRINGSTRING
AKN70512.1 AKN70512.1 AKN70756.1 AKN70756.1 AKN70832.1 AKN70832.1 AKN70868.1 AKN70868.1 AKN70956.1 AKN70956.1 AKN70961.1 AKN70961.1 AKN70967.1 AKN70967.1 AKN70999.1 AKN70999.1 AKN71200.1 AKN71200.1 AKN71201.1 AKN71201.1 acsA acsA pckG pckG AKN71349.1 AKN71349.1 AKN71404.1 AKN71404.1 AKN71438.1 AKN71438.1 AKN71612.1 AKN71612.1 AKN71631.1 AKN71631.1 AKN71668.1 AKN71668.1 AKN71687.1 AKN71687.1 AKN71704.1 AKN71704.1 AKN71827.1 AKN71827.1 AKN72228.1 AKN72228.1 AKN72264.1 AKN72264.1 AKN72372.1 AKN72372.1 AKN72377.1 AKN72377.1 ppc ppc AKN72526.1 AKN72526.1 mdh mdh AKN72748.1 AKN72748.1 AKN72828.1 AKN72828.1 AKN72875.1 AKN72875.1 AKN72920.1 AKN72920.1 AKN72979.1 AKN72979.1 AKN72983.1 AKN72983.1 AKN73006.1 AKN73006.1 AKN73042.1 AKN73042.1 AKN73104.1 AKN73104.1 AKN73115.1 AKN73115.1 AKN73131.1 AKN73131.1 AKN73154.1 AKN73154.1 AKN75612.1 AKN75612.1 AKN73239.1 AKN73239.1 AKN73436.1 AKN73436.1 AKN75643.1 AKN75643.1 AKN73583.1 AKN73583.1 AKN73607.1 AKN73607.1 AKN73622.1 AKN73622.1 AKN68462.1 AKN68462.1 AKN68484.1 AKN68484.1 AKN68485.1 AKN68485.1 AKN68653.1 AKN68653.1 AKN68659.1 AKN68659.1 AKN68660.1 AKN68660.1 AKN74340.1 AKN74340.1 AKN74357.1 AKN74357.1 AKN74421.1 AKN74421.1 AKN74507.1 AKN74507.1 AKN74536.1 AKN74536.1 AKN74568.1 AKN74568.1 AKN74650.1 AKN74650.1 AKN74753.1 AKN74753.1 AKN75815.1 AKN75815.1 AKN74771.1 AKN74771.1 AKN74785.1 AKN74785.1 AKN74835.1 AKN74835.1 AKN74941.1 AKN74941.1 ackA ackA AKN69871.1 AKN69871.1 AKN69852.1 AKN69852.1 AKN69790.1 AKN69790.1 leuA leuA AKN69738.1 AKN69738.1 AKN69636.1 AKN69636.1 AKN69542.1 AKN69542.1 AKN69498.1 AKN69498.1 AKN69494.1 AKN69494.1 AKN69361.1 AKN69361.1 AKN69493.1 AKN69493.1 AKN69346.1 AKN69346.1 AKN69337.1 AKN69337.1 AKN69305.1 AKN69305.1 aspA aspA AKN69235.1 AKN69235.1 AKN69066.1 AKN69066.1 AKN68994.1 AKN68994.1 AKN68973.1 AKN68973.1 AKN68972.1 AKN68972.1 AKN68882.1 AKN68882.1 AKN68873.1 AKN68873.1 AKN68821.1 AKN68821.1 AKN68820.1 AKN68820.1 AKN73743.1 AKN73743.1 AKN73770.1 AKN73770.1 AKN73830.1 AKN73830.1 AKN73854.1 AKN73854.1 AKN73930.1 AKN73930.1 AKN73980.1 AKN73980.1 AKN74099.1 AKN74099.1 AKN74135.1 AKN74135.1 AKN74136.1 AKN74136.1 AKN74211.1 AKN74211.1 AKN74337.1 AKN74337.1 AKN69873.1 AKN69873.1 leuA-2 leuA-2 AKN69966.1 AKN69966.1 AKN69988.1 AKN69988.1 AKN70042.1 AKN70042.1 AKN70081.1 AKN70081.1 AKN70172.1 AKN70172.1 AKN70243.1 AKN70243.1 AKN70256.1 AKN70256.1 AKN70257.1 AKN70257.1 AKN70258.1 AKN70258.1 AKN70267.1 AKN70267.1 AKN70268.1 AKN70268.1 AKN70269.1 AKN70269.1 AKN70378.1 AKN70378.1 AKN70499.1 AKN70499.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKN70512.1Thiamine biosynthesis protein ThiJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
AKN70756.1CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (715 aa)
AKN70832.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
AKN70868.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
AKN70956.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
AKN70961.1Deazaflavin-dependent nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
AKN70967.1pimeloyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (739 aa)
AKN70999.1Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AKN71200.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
AKN71201.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
AKN71349.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AKN71404.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
AKN71438.1Hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
AKN71612.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
AKN71631.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
AKN71668.1Isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
AKN71687.1Biotin carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
AKN71704.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AKN71827.1UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
AKN72228.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AKN72264.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AKN72372.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
AKN72377.1acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (977 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (910 aa)
AKN72526.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AKN72748.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
AKN72828.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
AKN72875.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AKN72920.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
AKN72979.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
AKN72983.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (580 aa)
AKN73006.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
AKN73042.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
AKN73104.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (580 aa)
AKN73115.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AKN73131.1Chaperone protein HchA; Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
AKN73154.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
AKN75612.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AKN73239.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa)
AKN73436.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
AKN75643.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
AKN73583.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
AKN73607.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (598 aa)
AKN73622.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AKN68462.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
AKN68484.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AKN68485.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
AKN68653.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
AKN68659.1Lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)
AKN68660.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
AKN74340.1Nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
AKN74357.1Lactate 2-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
AKN74421.1Hydrogenase maturation protein HypF; Derived by automated computational analysis using gene prediction method: Protein Homology. (783 aa)
AKN74507.1CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (896 aa)
AKN74536.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (338 aa)
AKN74568.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
AKN74650.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
AKN74753.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
AKN75815.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (440 aa)
AKN74771.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
AKN74785.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AKN74835.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
AKN74941.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
AKN69871.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
AKN69852.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
AKN69790.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
AKN69738.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (906 aa)
AKN69636.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
AKN69542.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (428 aa)
AKN69498.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
AKN69494.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AKN69361.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
AKN69493.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
AKN69346.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AKN69337.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
AKN69305.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
AKN69235.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (556 aa)
AKN69066.1Peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (427 aa)
AKN68994.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
AKN68973.1Iron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
AKN68972.1Peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (416 aa)
AKN68882.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AKN68873.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AKN68821.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
AKN68820.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (483 aa)
AKN73743.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
AKN73770.1Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (541 aa)
AKN73830.1Metallo-beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
AKN73854.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AKN73930.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
AKN73980.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
AKN74099.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AKN74135.1ATP-grasp domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
AKN74136.1Biotin carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
AKN74211.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
AKN74337.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AKN69873.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (700 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (561 aa)
AKN69966.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AKN69988.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (537 aa)
AKN70042.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
AKN70081.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
AKN70172.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (462 aa)
AKN70243.1Sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
AKN70256.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
AKN70257.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AKN70258.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
AKN70267.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
AKN70268.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AKN70269.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AKN70378.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AKN70499.1Carboxylate--amine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
Your Current Organism:
Streptomyces sp. PBH53
NCBI taxonomy Id: 1577075
Other names: S. sp. PBH53
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