STRINGSTRING
AKN71588.1 AKN71588.1 AKN69568.1 AKN69568.1 AKN69599.1 AKN69599.1 AKN69636.1 AKN69636.1 AKN75171.1 AKN75171.1 AKN75193.1 AKN75193.1 glyA glyA AKN69851.1 AKN69851.1 AKN69852.1 AKN69852.1 AKN69865.1 AKN69865.1 glyA-2 glyA-2 gcvH gcvH gcvT gcvT AKN69966.1 AKN69966.1 AKN69996.1 AKN69996.1 AKN75216.1 AKN75216.1 AKN70148.1 AKN70148.1 AKN70177.1 AKN70177.1 AKN70361.1 AKN70361.1 gcvH-2 gcvH-2 AKN70467.1 AKN70467.1 AKN70522.1 AKN70522.1 AKN70643.1 AKN70643.1 glyA-3 glyA-3 AKN70845.1 AKN70845.1 AKN70975.1 AKN70975.1 purU purU AKN75349.1 AKN75349.1 AKN70996.1 AKN70996.1 AKN71035.1 AKN71035.1 AKN75364.1 AKN75364.1 AKN71173.1 AKN71173.1 AKN71174.1 AKN71174.1 acsA acsA AKN75385.1 AKN75385.1 AKN71404.1 AKN71404.1 AKN71420.1 AKN71420.1 AKN75401.1 AKN75401.1 AKN71535.1 AKN71535.1 AKN71612.1 AKN71612.1 AKN71631.1 AKN71631.1 AKN74863.1 AKN74863.1 AKN74474.1 AKN74474.1 AKN68906.1 AKN68906.1 AKN68873.1 AKN68873.1 AKN68837.1 AKN68837.1 AKN68799.1 AKN68799.1 AKN68605.1 AKN68605.1 AKN74473.1 AKN74473.1 AKN75769.1 AKN75769.1 AKN74319.1 AKN74319.1 AKN74164.1 AKN74164.1 AKN74140.1 AKN74140.1 AKN74099.1 AKN74099.1 AKN73770.1 AKN73770.1 AKN73750.1 AKN73750.1 AKN73749.1 AKN73749.1 acnA acnA AKN73748.1 AKN73748.1 AKN73746.1 AKN73746.1 AKN73581.1 AKN73581.1 gcvP gcvP AKN73519.1 AKN73519.1 AKN73513.1 AKN73513.1 AKN73252.1 AKN73252.1 AKN73249.1 AKN73249.1 AKN73154.1 AKN73154.1 AKN73006.1 AKN73006.1 AKN72969.1 AKN72969.1 AKN72767.1 AKN72767.1 AKN75559.1 AKN75559.1 AKN72577.1 AKN72577.1 mdh mdh AKN72386.1 AKN72386.1 AKN72385.1 AKN72385.1 AKN72228.1 AKN72228.1 AKN71827.1 AKN71827.1 AKN71854.1 AKN71854.1 AKN71961.1 AKN71961.1 AKN71962.1 AKN71962.1 AKN72022.1 AKN72022.1 AKN68915.1 AKN68915.1 AKN68919.1 AKN68919.1 AKN68939.1 AKN68939.1 AKN68994.1 AKN68994.1 AKN69337.1 AKN69337.1 AKN69355.1 AKN69355.1 AKN69359.1 AKN69359.1 AKN69468.1 AKN69468.1 AKN69542.1 AKN69542.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKN71588.1Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (760 aa)
AKN69568.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
AKN69599.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (638 aa)
AKN69636.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
AKN75171.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
AKN75193.1Peptidase S66 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa)
AKN69851.1methylmalonyl-CoA epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
AKN69852.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
AKN69865.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
AKN69966.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AKN69996.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
AKN75216.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
AKN70148.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
AKN70177.1Molybdopterin-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (756 aa)
AKN70361.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (83 aa)
gcvH-2Hypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa)
AKN70467.13-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
AKN70522.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AKN70643.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (82 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (484 aa)
AKN70845.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (536 aa)
AKN70975.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
AKN75349.1Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (367 aa)
AKN70996.1acetyl-CoA carboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (615 aa)
AKN71035.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
AKN75364.1Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (484 aa)
AKN71173.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
AKN71174.1Methylaspartate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (426 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AKN75385.1Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
AKN71404.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
AKN71420.1Phosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AKN75401.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
AKN71535.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AKN71612.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
AKN71631.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
AKN74863.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
AKN74474.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (864 aa)
AKN68906.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
AKN68873.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AKN68837.1Dimethylmenaquinone methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1011 aa)
AKN68799.1Keto-deoxy-phosphogluconate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
AKN68605.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
AKN74473.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
AKN75769.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
AKN74319.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
AKN74164.1N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
AKN74140.1Polyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (3485 aa)
AKN74099.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AKN73770.1Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (541 aa)
AKN73750.1Hydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the hyi family. (279 aa)
AKN73749.1Tartronate semialdehyde reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
AKN73748.1Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (485 aa)
AKN73746.1Glyoxylate carboligase; Catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (592 aa)
AKN73581.1Peptidase U61; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
AKN73519.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (378 aa)
AKN73513.1Protein meaA; Derived by automated computational analysis using gene prediction method: Protein Homology. (675 aa)
AKN73252.1RNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (576 aa)
AKN73249.1Lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AKN73154.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
AKN73006.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
AKN72969.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (770 aa)
AKN72767.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
AKN75559.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
AKN72577.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AKN72386.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
AKN72385.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (388 aa)
AKN72228.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AKN71827.1UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
AKN71854.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
AKN71961.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (601 aa)
AKN71962.1methylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: Protein Homology. (724 aa)
AKN72022.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (456 aa)
AKN68915.1Arsenate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (122 aa)
AKN68919.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
AKN68939.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (453 aa)
AKN68994.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
AKN69337.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
AKN69355.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (590 aa)
AKN69359.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (537 aa)
AKN69468.1Dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
AKN69542.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (428 aa)
Your Current Organism:
Streptomyces sp. PBH53
NCBI taxonomy Id: 1577075
Other names: S. sp. PBH53
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