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| | pylD | 3-methylornithyl-N6-L-lysine dehydrogenase. (272 aa) |
| | pylC | 3-methylornithine--L-lysine ligase. (386 aa) |
| | pylB2 | 3-methylornithine synthase. (353 aa) |
| | pylS | pyrrolysine--tRNA ligase. (235 aa) |
| | sufS | Cysteine desulfurase. (407 aa) |
| | iscS2 | Cysteine desulfurase IscS 2; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (394 aa) |
| | AIZ56491.1 | BadF/BadG/BcrA/BcrD ATPase family protein. (407 aa) |
| | ileS2 | isoleucine--tRNA ligase. (901 aa) |
| | glyQS | glycine--tRNA ligase. (570 aa) |
| | hcaB | 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase. (106 aa) |
| | AIZ56539.1 | Short chain dehydrogenase. (152 aa) |
| | cysS | cysteine--tRNA ligase. (492 aa) |
| | cobQ1 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (605 aa) |
| | cobQ2 | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (278 aa) |
| | nadA | Quinolinate synthase A. (299 aa) |
| | gltX | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (561 aa) |
| | AIZ56587.1 | uroporphyrinogen-III synthase. (250 aa) |
| | glyA | Serine hydroxymethyltransferase. (427 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (225 aa) |
| | aspS2 | aspartate--tRNA ligase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). (434 aa) |
| | acsA3 | Acetyl-coenzyme A synthetase. (553 aa) |
| | pheA | Prephenate dehydratase. (283 aa) |
| | pyrB | Aspartate carbamoyltransferase. (311 aa) |
| | porD | Pyruvate ferredoxin oxidoreductase delta subunit PorD. (92 aa) |
| | porG | Pyruvate ferredoxin oxidoreductase gamma subunit PorC. (171 aa) |
| | ppsA | Putative phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (769 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (113 aa) |
| | hisS | histidine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (415 aa) |
| | lysS | lysine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (518 aa) |
| | cobB3 | Cobyrinic acid A,C-diamide synthase. (440 aa) |
| | AIZ56693.1 | Homoserine dehydrogenase. (340 aa) |
| | leuA2 | 2-isopropylmalate synthase. (524 aa) |
| | glmS | Glutamine--fructose-6-phosphate aminotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (469 aa) |
| | AIZ56755.1 | HyfE-like protein. (219 aa) |
| | pdaD | Pyruvoyl-dependent arginine decarboxylase. (157 aa) |
| | AIZ56782.1 | Glycolate oxidase subunit GlcD. (477 aa) |
| | argS | arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (571 aa) |
| | dtdA | D-tyrosyl-tRNA(Tyr) deacylase; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. (282 aa) |
| | pheS | phenylalanine--tRNA ligase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (506 aa) |
| | trpS | tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). (373 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (355 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (419 aa) |
| | aroK | Shikimate kinase. (278 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (436 aa) |
| | aroA'1 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (264 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (441 aa) |
| | aroA'2 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (263 aa) |
| | aroB | 3-dehydroquinate synthase. (339 aa) |
| | aroQ | Chorismate mutase / prephenate dehydrogenase. (350 aa) |
| | tyrS | tyrosine--tRNA ligase. (355 aa) |
| | dapH2 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase. (189 aa) |
| | rbn1 | Ribonuclease BN. (278 aa) |
| | AIZ56977.1 | Hypothetical protein. (303 aa) |
| | aldhT | 2,5-dioxopentanoate dehydrogenase. (460 aa) |
| | AIZ56985.1 | Putative methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (332 aa) |
| | AIZ57013.1 | Acetolactate synthase 3 regulatory subunit. (120 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa) |
| | maeA | NAD-dependent malic enzyme. (472 aa) |
| | guaAA | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. (192 aa) |
| | trpB12 | Tryptophan synthase beta chain 1. (440 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa) |
| | folD | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | AIZ57156.1 | Glutamate synthase domain-containing protein. (540 aa) |
| | AIZ57170.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa) |
| | AIZ57171.1 | Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. (356 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (278 aa) |
| | proS | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (467 aa) |
| | AIZ57199.1 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase. (396 aa) |
| | AIZ57211.1 | Homoserine dehydrogenase. (323 aa) |
| | AIZ57225.1 | Phosphoserine phosphatase. (219 aa) |
| | gloB2 | Hydroxyacylglutathione hydrolase. (191 aa) |
| | gatD | glutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (432 aa) |
| | AIZ57303.1 | 7, 8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)- aminobenzene-5'-phosphate synthase. (253 aa) |
| | AIZ57312.1 | Putative metallohydrolase. (406 aa) |
| | fadA2 | acetyl-CoA acetyltransferase. (392 aa) |
| | hisF2 | Imidazole glycerol phosphate synthase subunit HisF. (238 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH. (195 aa) |
| | aspC3 | Aspartate aminotransferase. (351 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | asd1 | Aspartate-semialdehyde dehydrogenase. (354 aa) |
| | AIZ56147.1 | Chorismate mutase. (112 aa) |
| | cimA | (R)-citramalate synthase CimA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa) |
| | trpG2 | Anthranilate synthase component 2; Belongs to the CarA family. (361 aa) |
| | pycA | Pyruvate carboxylase subunit A; Belongs to the CarB family. (1068 aa) |
| | aksF1 | Homoisocitrate dehydrogenase. (372 aa) |
| | leuD | Isopropylmalate/citramalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | leuC1 | Isopropylmalate/citramalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa) |
| | leuA1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa) |
| | thrC1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (405 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa) |
| | fadA1 | 3-ketoacyl-CoA thiolase. (389 aa) |
| | hmgB | hydroxymethylglutaryl-CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (351 aa) |
| | AIZ56200.1 | Cysteine synthase. (301 aa) |
| | AIZ56202.1 | Isocitrate/isopropylmalate dehydrogenase. (408 aa) |
| | pylB1 | 3-methylornithine synthase. (383 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (182 aa) |
| | thrS | threonine--tRNA ligase. (611 aa) |
| | AIZ56215.1 | O-acetylhomoserine sulfhydrylase. (356 aa) |
| | argH | Argininosuccinate lyase. (483 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (415 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (338 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (410 aa) |
| | argB | Acetylglutamate/acetylaminoadipate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (273 aa) |
| | hemL1 | Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (390 aa) |
| | AIZ56229.1 | Asparagine synthetase B. (339 aa) |
| | metA | Homoserine O-succinyltransferase. (310 aa) |
| | metG | methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (740 aa) |
| | leuB | 3-isopropylmalate/3-methylmalate dehydrogenase. (334 aa) |
| | AIZ56276.1 | Hypothetical protein. (391 aa) |
| | nudI | Nucleoside triphosphatase NudI. (260 aa) |
| | ileS1 | isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (982 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (421 aa) |
| | AIZ56293.1 | Asparagine synthetase B. (264 aa) |
| | dapH1 | Serine acetyltransferase. (214 aa) |
| | pheT | phenylalanine--tRNA ligase beta subunit. (551 aa) |
| | AIZ56389.1 | Hypothetical protein. (349 aa) |
| | cobB2 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (451 aa) |
| | iorB | Indolepyruvate oxidoreductase subunit IorB. (194 aa) |
| | leuS | leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (956 aa) |
| | apgM1 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa) |
| | menE | 2-succinylbenzoate--CoA ligase. (432 aa) |
| | AIZ56455.1 | acyl-CoA synthetase. (434 aa) |
| | hisF1 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (200 aa) |
| | mtnP | S-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (263 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase. (330 aa) |
| | acsA1 | Acetyl-coenzyme A synthetase. (650 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (418 aa) |
| | AIZ56108.1 | Iron-binding zinc finger CDGSH type. (213 aa) |
| | argF | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (304 aa) |
| | serS1 | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (420 aa) |
| | AIZ56065.1 | Ferredoxin. (57 aa) |
| | gloB1 | Hydroxyacylglutathione hydrolase. (213 aa) |
| | alaS2 | alanine--tRNA ligase. (586 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase. (338 aa) |
| | pgk | Phosphoglycerate kinase. (390 aa) |
| | dapL | LL-diaminopimelate aminotransferase. (390 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (289 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (259 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (548 aa) |
| | aspS1 | aspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (605 aa) |
| | alaS1 | alanine--tRNA ligase. (392 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB11 | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (201 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (255 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | trpE | Anthranilate synthase component 1. (485 aa) |
| | glnA | Glutamine synthetase. (726 aa) |
