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| | SDQ26999.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (800 aa) |
| | SDQ31991.1 | Dihydrolipoamide dehydrogenase. (592 aa) |
| | SDQ32017.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (550 aa) |
| | SDQ32047.1 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa) |
| | SDQ33407.1 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component. (465 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (568 aa) |
| | SDQ34980.1 | acetyl-CoA synthetase. (554 aa) |
| | SDQ36517.1 | propionyl-CoA synthetase. (634 aa) |
| | SDQ37240.1 | 4-hydroxybutyrate dehydrogenase. (382 aa) |
| | fumC | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa) |
| | SDQ49893.1 | Isocitrate dehydrogenase (NADP). (418 aa) |
| | SDQ50393.1 | Citrate synthase. (413 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | SDQ57831.1 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). (779 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (618 aa) |
| | SDQ69209.1 | 2-keto-4-methylthiobutyrate aminotransferase apoenzyme. (384 aa) |
| | SDQ71472.1 | Methylmalonate-semialdehyde dehydrogenase [acylating]. (517 aa) |
| | SDQ72535.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (581 aa) |
| | SDQ77487.1 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+); Belongs to the malic enzymes family. (760 aa) |
| | SDQ77526.1 | Indolepyruvate ferredoxin oxidoreductase. (1198 aa) |
| | SDQ80908.1 | Indolepyruvate ferredoxin oxidoreductase. (1195 aa) |
| | icmF | methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1126 aa) |
| | SDQ85307.1 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (361 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa) |
| | SDQ87517.1 | Fe-S oxidoreductase. (1368 aa) |
| | SDQ90239.1 | D-lactate dehydrogenase (cytochrome). (472 aa) |
| | SDQ93111.1 | D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (331 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (557 aa) |
| | ppc | Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1079 aa) |
| | SDQ99813.1 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (508 aa) |
| | SDQ99874.1 | Acetyl-coenzyme A synthetase. (686 aa) |
| | SDR00106.1 | Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (479 aa) |
| | SDR02121.1 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (746 aa) |
| | SDR02914.1 | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. (478 aa) |
| | SDR05022.1 | Acetolactate synthase, large subunit. (587 aa) |
| | SDR05053.1 | Acetolactate synthase, small subunit. (163 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa) |
| | SDR06347.1 | 2-keto-4-methylthiobutyrate aminotransferase apoenzyme. (390 aa) |
| | SDR07456.1 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | SDR10237.1 | Rhodanese-related sulfurtransferase. (533 aa) |
| | SDR13045.1 | 2-oxoglutarate dehydrogenase E1 component. (953 aa) |
| | SDR13067.1 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (424 aa) |
| | SDR13093.1 | Dihydrolipoamide dehydrogenase. (480 aa) |
| | glcB | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (724 aa) |
| | SDR23108.1 | Phosphate butyryltransferase. (467 aa) |
| | SDR23478.1 | Phosphate acetyltransferase. (147 aa) |
| | SDR23804.1 | L(+)-tartrate dehydratase beta subunit. (203 aa) |
| | SDR23820.1 | Fumarate hydratase subunit alpha/L(+)-tartrate dehydratase alpha subunit. (289 aa) |
| | SDR23834.1 | Succinate dehydrogenase subunit C. (139 aa) |
| | SDR23851.1 | Fumarate reductase subunit C. (110 aa) |
| | SDR23866.1 | Fumarate reductase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (243 aa) |
| | SDR23970.1 | acrylyl-CoA reductase (NADPH). (335 aa) |
| | SDR23998.1 | Alcohol dehydrogenase. (385 aa) |
| | SDR24457.1 | 2-oxoglutarate dehydrogenase E1 component. (965 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa) |
| | SDR25354.1 | 2,5-dioxopentanoate dehydrogenase (NAD+). (481 aa) |
| | SDR25514.1 | Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (592 aa) |
| | SDR42860.1 | Uncharacterized zinc-type alcohol dehydrogenase-like protein. (350 aa) |
| | SDR43638.1 | succinyl-CoA:acetate CoA-transferase. (505 aa) |
| | SDR44595.1 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (315 aa) |
| | SDR45158.1 | 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (305 aa) |
| | SDR45165.1 | Methylmalonate-semialdehyde dehydrogenase [acylating]. (513 aa) |
| | SDR45173.1 | acetyl-CoA synthetase. (563 aa) |
| | SDR45598.1 | Succinyl-CoA synthetase, beta subunit. (434 aa) |
| | SDR45605.1 | Succinyl-CoA synthetase, alpha subunit. (899 aa) |
| | SDR46374.1 | Tricarballylate dehydrogenase. (467 aa) |
| | SDR46380.1 | Citrate/tricarballylate utilization protein. (389 aa) |
| | SDR46448.1 | MFS transporter, AAHS family, 4-hydroxybenzoate transporter. (472 aa) |
| | SDR46459.1 | Aldehyde dehydrogenase family protein. (223 aa) |
| | SDR46465.1 | Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (547 aa) |
| | SDR46504.1 | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit. (651 aa) |
| | SDR49111.1 | Citrate synthase. (414 aa) |
| | ilvD-2 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (620 aa) |
| | SDR49337.1 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (742 aa) |
| | SDR51050.1 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. (364 aa) |
| | SDR51644.1 | FAD/FMN-containing dehydrogenase. (1010 aa) |
| | SDR51723.1 | Acetyltransferase. (821 aa) |
| | SDR51845.1 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa) |
| | SDR51849.1 | 2-methylcitrate dehydratase. (483 aa) |
| | SDR51859.1 | 2-methylcitrate synthase; Belongs to the citrate synthase family. (395 aa) |
| | mdh | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa) |
| | SDR51880.1 | Succinate dehydrogenase subunit C. (138 aa) |
| | SDR51884.1 | Succinate dehydrogenase subunit D. (122 aa) |
| | SDR51889.1 | Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (591 aa) |
| | SDR51894.1 | Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (234 aa) |
| | SDR51899.1 | Antitoxin CptB. (90 aa) |
| | SDR51905.1 | Citrate synthase; Belongs to the citrate synthase family. (433 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (217 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) |
| | SDR52369.1 | FAD/FMN-containing dehydrogenase. (996 aa) |
| | SDR52380.1 | 2-Methylisocitrate lyase, PEP mutase family. (273 aa) |
| | SDR52573.1 | Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (499 aa) |
| | SDR53360.1 | 3-oxosteroid 1-dehydrogenase. (569 aa) |
| | SDR53365.1 | Pyruvate dehydrogenase E1 component alpha subunit. (328 aa) |
| | SDR53370.1 | Pyruvate dehydrogenase E1 component beta subunit. (330 aa) |
| | SDR53375.1 | Biotin-requiring enzyme. (76 aa) |
| | SDR53380.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (271 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (362 aa) |
| | SDR53631.1 | Pyruvate dehydrogenase E1 component beta subunit. (325 aa) |
| | SDR53635.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (371 aa) |
| | SDR53851.1 | Phosphate acetyltransferase. (311 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (391 aa) |
| | SDR54706.1 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. (360 aa) |
| | SDR54767.1 | 2-methylcitrate synthase; Belongs to the citrate synthase family. (389 aa) |
| | SDR54773.1 | Aconitase /2-methylcitrate dehydratase (trans-methylaconitate-forming). (865 aa) |
| | SDR54779.1 | 2-methylaconitate cis-trans isomerase. (395 aa) |
| | SDR54908.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (587 aa) |
| | frc | formyl-CoA transferase; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl- CoA to oxalate; Belongs to the CoA-transferase III family. Frc subfamily. (415 aa) |
| | SDR54918.1 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (271 aa) |
| | SDR56088.1 | Citrate synthase; Belongs to the citrate synthase family. (463 aa) |
| | SDR56275.1 | 2-Methylisocitrate lyase, PEP mutase family. (294 aa) |
| | SDR56549.1 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. (611 aa) |
| | SDR56682.1 | Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase. (797 aa) |
| | SDR56685.1 | Acetate kinase. (64 aa) |
| | SDR58956.1 | Alcohol dehydrogenase, propanol-preferring. (329 aa) |
| | SDR59019.1 | Acetolactate synthase-1/2/3 large subunit; Manually curated; Belongs to the TPP enzyme family. (582 aa) |
| | SDR59051.1 | Aconitase; Belongs to the aconitase/IPM isomerase family. (861 aa) |
| | SDR59417.1 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (573 aa) |
| | SDR59450.1 | ATP citrate lyase subunit 1. (428 aa) |
| | SDR59454.1 | Succinyl-CoA synthetase, alpha subunit. (899 aa) |
| | SDR59498.1 | Succinate semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (492 aa) |
| | SDR59502.1 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. (362 aa) |
| | SDR59859.1 | 2-methylcitrate dehydratase PrpD. (389 aa) |
| | SDR59969.1 | Homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (378 aa) |
| | SDR60007.1 | Homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (378 aa) |
| | SDR60283.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (369 aa) |
| | SDR60285.1 | Pyruvate dehydrogenase E1 component beta subunit. (334 aa) |
| | SDR60287.1 | Pyruvate dehydrogenase E1 component alpha subunit. (327 aa) |
| | SDR61002.1 | Succinyl-CoA synthetase, alpha subunit. (899 aa) |
| | SDR61010.1 | Hypothetical protein. (131 aa) |
| | SDR61121.1 | Alcohol dehydrogenase. (425 aa) |
| | SDR61150.1 | Citrate synthase. (271 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (210 aa) |
| | SDR61327.1 | Aldehyde dehydrogenase (NAD+). (479 aa) |
| | SDR61338.1 | Uncharacterized zinc-type alcohol dehydrogenase-like protein. (350 aa) |
| | SDR61362.1 | 2-methylcitrate dehydratase PrpD. (461 aa) |
| | SDR61421.1 | 2,4-dienoyl-CoA reductase. (734 aa) |
| | SDR61455.1 | 4-aminobutyrate aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (436 aa) |
| | SDR61651.1 | Tricarballylate dehydrogenase. (485 aa) |
| | SDR61675.1 | Alcohol dehydrogenase. (374 aa) |
| | SDR62272.1 | Indolepyruvate ferredoxin oxidoreductase. (1193 aa) |
