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SDQ28002.1 SDQ28002.1 SDQ28035.1 SDQ28035.1 hisZ hisZ SDQ33515.1 SDQ33515.1 aroC aroC aroA aroA SDQ43466.1 SDQ43466.1 hisC hisC SDQ43537.1 SDQ43537.1 SDQ46035.1 SDQ46035.1 aroE aroE aroQ aroQ trpE trpE SDQ61492.1 SDQ61492.1 trpD trpD trpC trpC SDQ63268.1 SDQ63268.1 SDQ63304.1 SDQ63304.1 hisE hisE hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC-2 hisC-2 hisD hisD hisG hisG aroB aroB aroK-2 aroK-2 SDQ67265.1 SDQ67265.1 SDQ71330.1 SDQ71330.1 SDQ82602.1 SDQ82602.1 SDQ83162.1 SDQ83162.1 SDQ85339.1 SDQ85339.1 hisC-3 hisC-3 SDQ90385.1 SDQ90385.1 SDQ90887.1 SDQ90887.1 hmgA hmgA SDQ92801.1 SDQ92801.1 ubiC ubiC SDR07001.1 SDR07001.1 SDR15567.1 SDR15567.1 hisD-2 hisD-2 SDR24243.1 SDR24243.1 SDR44673.1 SDR44673.1 SDR44688.1 SDR44688.1 SDR46235.1 SDR46235.1 aroE-2 aroE-2 aroQ-2 aroQ-2 SDR46799.1 SDR46799.1 SDR47858.1 SDR47858.1 SDR48242.1 SDR48242.1 trpF trpF trpB trpB trpA trpA SDR52343.1 SDR52343.1 SDR54811.1 SDR54811.1 SDR56340.1 SDR56340.1 aroQ-3 aroQ-3 SDR60219.1 SDR60219.1 SDR60221.1 SDR60221.1 SDR60223.1 SDR60223.1 SDR61398.1 SDR61398.1 SDR61464.1 SDR61464.1 SDR61597.1 SDR61597.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SDQ28002.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (356 aa)
SDQ28035.1Major Facilitator Superfamily protein. (452 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (383 aa)
SDQ33515.1Transcriptional regulator, GntR family. (488 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa)
SDQ43466.1Prephenate dehydrogenase. (341 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa)
SDQ43537.1Chorismate mutase. (359 aa)
SDQ46035.1Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. (198 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (287 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
trpEAnthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (497 aa)
SDQ61492.1Anthranilate synthase, component II. (205 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (343 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (261 aa)
SDQ63268.1Histidine triad (HIT) family protein. (121 aa)
SDQ63304.1Uncharacterized membrane protein. (131 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (131 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (136 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (250 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa)
hisBImidazoleglycerol-phosphate dehydratase. (195 aa)
hisC-2Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (444 aa)
hisGATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (233 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (361 aa)
aroK-2Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (183 aa)
SDQ67265.14-hydroxyphenylpyruvate dioxygenase. (365 aa)
SDQ71330.1Pterin-4-alpha-carbinolamine dehydratase. (96 aa)
SDQ82602.1Fumarylacetoacetate (FAA) hydrolase. (327 aa)
SDQ83162.1D-alanine transaminase. (319 aa)
SDQ85339.1Anthranilate phosphoribosyltransferase. (391 aa)
hisC-3Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
SDQ90385.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (357 aa)
SDQ90887.1Para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase. (628 aa)
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (448 aa)
SDQ92801.1Fumarylacetoacetate hydrolase. (432 aa)
ubiCChorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (238 aa)
SDR07001.1Aromatic-amino-acid transaminase. (399 aa)
SDR15567.1phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (125 aa)
hisD-2Sulfopropanediol 3-dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa)
SDR24243.1Shikimate dehydrogenase. (287 aa)
SDR44673.1Maleylpyruvate isomerase. (193 aa)
SDR44688.1Fumarylacetoacetate hydrolase. (439 aa)
SDR46235.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (372 aa)
aroE-2Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (316 aa)
aroQ-23-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
SDR46799.14-hydroxyphenylpyruvate dioxygenase. (630 aa)
SDR47858.1Transcriptional regulator, GntR family. (495 aa)
SDR48242.1Transcriptional regulator, GntR family. (471 aa)
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (243 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa)
SDR52343.14-hydroxyphenylpyruvate dioxygenase. (375 aa)
SDR54811.1Shikimate dehydrogenase. (282 aa)
SDR56340.1Aromatic-amino-acid transaminase. (399 aa)
aroQ-33-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa)
SDR60219.1Aromatic-amino-acid transaminase. (401 aa)
SDR60221.1Aromatic amino acid:proton symporter, AAT family. (460 aa)
SDR60223.14-hydroxyphenylpyruvate dioxygenase. (357 aa)
SDR61398.1Fumarylacetoacetate (FAA) hydrolase. (325 aa)
SDR61464.1Transcriptional regulator, GntR family. (463 aa)
SDR61597.1Aspartate aminotransferase. (400 aa)
Your Current Organism:
Paraburkholderia tuberum
NCBI taxonomy Id: 157910
Other names: Burkholderia sp. WSM4174, Burkholderia sp. WSM4175, Burkholderia sp. WSM4176, Burkholderia sp. WSM4177, Burkholderia sp. WSM4179, Burkholderia sp. WSM4180, Burkholderia tuberum, Burkholderia tuberum Vandamme et al. 2003, CCUG 47178, CIP 108238, DSM 18489, LMG 21444, LMG:21444, P. tuberum, Paraburkholderia tuberum (Vandamme et al. 2003) Sawana et al. 2015, strain STM678
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