STRINGSTRING
AJW71334.1 AJW71334.1 queC queC glnA glnA AJW69850.1 AJW69850.1 AJW69852.1 AJW69852.1 guaA guaA AJW70120.1 AJW70120.1 purA purA glnA-2 glnA-2 AJW70230.1 AJW70230.1 argG argG purD purD carA carA carB carB AJW70645.1 AJW70645.1 nadE nadE AJW70750.1 AJW70750.1 pyrG pyrG purP purP AJW70871.1 AJW70871.1 gatA gatA gatB gatB purK purK bioD bioD purL purL purQ purQ purS purS AJW70994.1 AJW70994.1 AJW71028.1 AJW71028.1 cofE cofE purM purM AJW71434.1 AJW71434.1 AJW71796.1 AJW71796.1 gatE gatE cobB-2 cobB-2 AJW71877.1 AJW71877.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJW71334.1ATP-binding protein. (226 aa)
queC7-cyano-7-deazaguanine synthase. (224 aa)
glnAGlutamine synthetase. (486 aa)
AJW69850.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase. (412 aa)
AJW69852.14-phosphopantoate--beta-alanine ligase. (254 aa)
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (507 aa)
AJW70120.1Asparagine synthase. (251 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (333 aa)
glnA-2Glutamine synthetase. (481 aa)
AJW70230.1Putative ketosteroid isomeraserelated protein-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (128 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (420 aa)
carACarbamoyl-phosphate synthase small chain. (342 aa)
carBCarbamoyl-phosphate synthase large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1017 aa)
AJW70645.1Biotin--acetyl-CoA-carboxylase ligase. (335 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (263 aa)
AJW70750.1Asparagine synthase. (314 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa)
purP5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (341 aa)
AJW70871.1Hypothetical protein; Homologs of previously reported genes of unknown function. (89 aa)
gatAGlutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (481 aa)
gatBAspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (469 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa)
bioDATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (228 aa)
purLPhosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (679 aa)
purQPhosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (230 aa)
purSPhosphoribosylformylglycinamidine synthase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assis [...] (86 aa)
AJW70994.1Hypothetical protein; Homologs of previously reported genes of unknown function. (363 aa)
AJW71028.1Putative ketosteroid isomeraserelated protein-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (127 aa)
cofECoenzyme F420:L-glutamate ligase. (241 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (340 aa)
AJW71434.1Putative gamma-glutamyl ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (280 aa)
AJW71796.1NH(3)-dependent NAD(+) synthetase. (324 aa)
gatEGlutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (647 aa)
cobB-2Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (451 aa)
AJW71877.1Class I glutamine amidotransferase. (180 aa)
Your Current Organism:
Nitrosopumilus adriaticus
NCBI taxonomy Id: 1580092
Other names: Candidatus Nitrosopumilus adriaticus, JCM 32270, N. adriaticus, NCIMB 15114, Nitrosopumilus adriaticus Bayer et al. 2019, Nitrosopumilus sp. NF5, strain NF5
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