STRINGSTRING
kdsC kdsC kdsD kdsD aspH aspH lpxH lpxH lpxK lpxK kdsB kdsB kdsA kdsA lpxD lpxD lpxA lpxA waaD waaD gmhA gmhA hldE hldE waaF waaF CEN56347.1 CEN56347.1 CEN56350.1 CEN56350.1 waaC waaC CEN56352.1 CEN56352.1 CEN56392.1 CEN56392.1 lpxC lpxC yraO yraO waaA waaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (179 aa)
kdsDD-arabinose 5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SIS family. GutQ/KpsF subfamily. (360 aa)
aspHFe(2+)/alpha-ketoglutarate-dependent dioxygenase lpxO. (314 aa)
lpxHUDP-2,3-diacylglucosamine pyrophosphatase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (250 aa)
lpxKLipid A 4'kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (333 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (254 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (279 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (343 aa)
lpxAUDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (261 aa)
waaDADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (322 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (187 aa)
hldEBifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphate kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (487 aa)
waaFADP-heptose:LPS heptosyltransferase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (344 aa)
CEN56347.1Putative O-antigen polymerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (406 aa)
CEN56350.1Glycosyl transferase family 9. (352 aa)
waaCADP-heptose:LPS heptosyl transferase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (323 aa)
CEN56352.1Lipid A biosynthesis acyltransferase. (281 aa)
CEN56392.1D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase. (179 aa)
lpxCUDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (309 aa)
yraODnaA initiator-associating factor for replication initiation; Function of homologous gene experimentally demonstrated in an other organism; factor. (196 aa)
waaA3-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (430 aa)
Your Current Organism:
Methylopumilus turicensis
NCBI taxonomy Id: 1581680
Other names: C. Methylopumilus turicensis, Candidatus Methylopumilus turicensis, Methylophilaceae bacterium MMS-10A-171
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