STRINGSTRING
ADY12390.1 ADY12390.1 ADY12469.1 ADY12469.1 purA purA ADY12486.1 ADY12486.1 thyX thyX ADY12757.1 ADY12757.1 ADY12759.1 ADY12759.1 ADY12903.1 ADY12903.1 purU purU ADY12962.1 ADY12962.1 ADY13055.1 ADY13055.1 ADY13081.1 ADY13081.1 apt apt dut dut tmk tmk folD folD ADY13280.1 ADY13280.1 ADY13292.1 ADY13292.1 adk adk ADY13296.1 ADY13296.1 ADY13308.1 ADY13308.1 ADY13328.1 ADY13328.1 ADY13371.1 ADY13371.1 ADY13464.1 ADY13464.1 cmk-2 cmk-2 ADY13631.1 ADY13631.1 ADY13751.1 ADY13751.1 udk udk ADY13822.1 ADY13822.1 ADY13823.1 ADY13823.1 ADY13824.1 ADY13824.1 pyrE pyrE ADY13826.1 ADY13826.1 ADY13888.1 ADY13888.1 ADY13912.1 ADY13912.1 ADY13964.1 ADY13964.1 ADY13965.1 ADY13965.1 ADY13968.1 ADY13968.1 purD purD ADY13970.1 ADY13970.1 purN purN purM purM purF purF purC purC purE purE ADY14407.1 ADY14407.1 ADY14526.1 ADY14526.1 ADY14596.1 ADY14596.1 surE surE ADY14612.1 ADY14612.1 ADY14749.1 ADY14749.1 ADY14767.1 ADY14767.1 ADY14803.1 ADY14803.1 ADY14834.1 ADY14834.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ADY12390.1KEGG: dal:Dalk_0201 dCMP deaminase; PFAM: CMP/dCMP deaminase, zinc-binding. (161 aa)
ADY12469.1KEGG: purB; adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal metazoa/fungi; Lyase 1, N-terminal; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (467 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
ADY12486.1TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: toc:Toce_2097 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (185 aa)
thyXThymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (273 aa)
ADY12757.1TIGRFAM: Purine nucleoside phosphorylase; KEGG: fma:FMG_0404 purine nucleoside phosphorylase; PFAM: Nucleoside phosphorylase domain. (238 aa)
ADY12759.1KEGG: tai:Taci_0564 ribosylpyrimidine nucleosidase; PFAM: Inosine/uridine-preferring nucleoside hydrolase domain. (305 aa)
ADY12903.1Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (207 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (290 aa)
ADY12962.1Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: fba:FIC_00553 phosphoribosylglycinamide formyltransferase. (240 aa)
ADY13055.1KEGG: ssm:Spirs_1451 metal-dependent phosphohydrolase HD sub domain protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain. (383 aa)
ADY13081.1PFAM: Nucleoside phosphorylase domain; TIGRFAM: Purine nucleoside phosphorylase; HAMAP: Purine nucleoside phosphorylase; KEGG: amt:Amet_4228 purine nucleoside phosphorylase. (235 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (177 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (203 aa)
folDBifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
ADY13280.1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (262 aa)
ADY13292.1KEGG: elm:ELI_1158 IMP dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core. (502 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (209 aa)
ADY13296.1KEGG: ssm:Spirs_1527 phosphoribosyl transferase domain-containing protein. (354 aa)
ADY13308.1PFAM: Adenylate cyclase; KEGG: ssm:Spirs_2340 adenylyl cyclase CyaB. (193 aa)
ADY13328.12',3'-cyclic-nucleotide 2'-phosphodiesterase; KEGG: amt:Amet_3609 5'-nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase; Belongs to the 5'-nucleotidase family. (594 aa)
ADY13371.1Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: tde:TDE1698 serine/threonine protein phosphatase family protein. (308 aa)
ADY13464.1Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (330 aa)
cmk-2KEGG: ssm:Spirs_2280 cytidylate kinase; TIGRFAM: Cytidylate kinase, putative; PFAM: Cytidylate kinase domain. (174 aa)
ADY13631.1PFAM: Xanthine/uracil/vitamin C permease; KEGG: bpo:BP951000_1268 integral membrane transport protein. (428 aa)
ADY13751.15'-nucleotidase; KEGG: ppm:PPSC2_c1154 5-nucleotidase domain protein; PFAM: 5'-Nucleotidase, C-terminal; Metallo-dependent phosphatase. (920 aa)
udkTIGRFAM: Uridine kinase; HAMAP: Uridine kinase; KEGG: ssm:Spirs_2239 uridine kinase; PFAM: Phosphoribulokinase/uridine kinase. (203 aa)
ADY13822.1KEGG: tde:TDE2107 dihydroorotase, putative. (348 aa)
ADY13823.1KEGG: tde:TDE0982 dihydroorotate dehydrogenase/oxidoreductase, FAD-binding; TIGRFAM: Dihydroorotate dehydrogenase, class 1; PFAM: Dihydroorotate dehydrogenase, class 1/ 2; Oxidoreductase, FAD-binding domain; Oxidoreductase FAD/NAD(P)-binding; Belongs to the dihydroorotate dehydrogenase family. (577 aa)
ADY13824.1SMART: Orotidine 5'-phosphate decarboxylase domain; TIGRFAM: Orotidine 5'-phosphate decarboxylase, type 2; KEGG: tde:TDE2110 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase domain. (288 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (232 aa)
ADY13826.1TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; KEGG: tde:TDE0129 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Aspartate carbamoyltransferase regulatory subunit, N-terminal; Aspartate carbamoyltransferase regulatory subunit, C-terminal. (534 aa)
ADY13888.1Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (233 aa)
ADY13912.1Dihydropyrimidinase; KEGG: ssm:Spirs_2735 dihydropyrimidinase; PFAM: Amidohydrolase 1. (466 aa)
ADY13964.1TIGRFAM: Glutamate synthase (NADPH), homotetrameric; KEGG: ssm:Spirs_1641 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (495 aa)
ADY13965.1PFAM: Oxidoreductase FAD/NAD(P)-binding; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; KEGG: ssm:Spirs_1640 oxidoreductase FAD/NAD(P)-binding domain protein. (282 aa)
ADY13968.1TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; KEGG: mla:Mlab_0300 carbamoyl-phosphate synthase, large subunit; PFAM: AIR synthase-related protein, C-terminal. (1215 aa)
purDPhosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: phosphoribosylamine/glycine ligase; Belongs to the GARS family. (440 aa)
ADY13970.1Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; KEGG: bvu:BVU_1693 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain. (385 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (431 aa)
purMTIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein; AIR synthase-related protein, C-terminal. (344 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (466 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; TIGRFAM: SAICAR synthetase; HAMAP: SAICAR synthetase; KEGG: phosphoribosylaminoimidazole-succinocarboxamide synthase. (237 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa)
ADY14407.1KEGG: uracil-xanthine permease; TIGRFAM: Xanthine/uracil permease; PFAM: Xanthine/uracil/vitamin C permease. (417 aa)
ADY14526.1KEGG: ssm:Spirs_3643 uracil-xanthine permease; TIGRFAM: Xanthine/uracil permease; PFAM: Xanthine/uracil/vitamin C permease. (427 aa)
ADY14596.1SMART: ATPase, AAA+ type, core; KEGG: ssm:Spirs_3160 AAA ATPase. (561 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (266 aa)
ADY14612.1Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: ssm:Spirs_3193 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C-domain. (418 aa)
ADY14749.1SMART: Methylglyoxal synthase-like domain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: sta:STHERM_c07390 carbamoyl-phosphate synthase large chain; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Belongs to the CarB family. (1069 aa)
ADY14767.1PFAM: Adenosine/AMP deaminase; TIGRFAM: Adenosine deaminase; HAMAP: Adenosine deaminase; KEGG: ssm:Spirs_0300 adenosine deaminase. (367 aa)
ADY14803.1Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (276 aa)
ADY14834.1PFAM: Thymidine kinase; KEGG: ssm:Spirs_0100 thymidine kinase; Belongs to the thymidine kinase family. (380 aa)
Your Current Organism:
Sphaerochaeta globosa
NCBI taxonomy Id: 158189
Other names: S. globosa str. Buddy, Sphaerochaeta globosa str. Buddy, Sphaerochaeta sp. Buddy, Spirochaeta sp. Buddy
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