STRINGSTRING
ilvC ilvC ADY12623.1 ADY12623.1 ADY12551.1 ADY12551.1 hisD hisD ADY12461.1 ADY12461.1 ADY12403.1 ADY12403.1 ADY12375.1 ADY12375.1 ADY12367.1 ADY12367.1 ADY12365.1 ADY12365.1 ADY12329.1 ADY12329.1 ADY12271.1 ADY12271.1 ADY12255.1 ADY12255.1 ADY12253.1 ADY12253.1 ADY12223.1 ADY12223.1 ADY12216.1 ADY12216.1 ADY12188.1 ADY12188.1 ADY12166.1 ADY12166.1 ADY14816.1 ADY14816.1 ADY14787.1 ADY14787.1 ADY14775.1 ADY14775.1 ADY14543.1 ADY14543.1 ADY14525.1 ADY14525.1 ADY14523.1 ADY14523.1 ADY14478.1 ADY14478.1 ADY14443.1 ADY14443.1 ADY14382.1 ADY14382.1 ADY12101.1 ADY12101.1 aroE aroE ADY12019.1 ADY12019.1 ADY14361.1 ADY14361.1 ADY14088.1 ADY14088.1 ADY14073.1 ADY14073.1 ADY14040.1 ADY14040.1 ADY14034.1 ADY14034.1 ADY13876.1 ADY13876.1 ADY13784.1 ADY13784.1 murB murB ADY13467.1 ADY13467.1 ADY13455.1 ADY13455.1 ADY13292.1 ADY13292.1 ADY13147.1 ADY13147.1 aroE-2 aroE-2 dxr dxr ADY13017.1 ADY13017.1 ADY12979.1 ADY12979.1 ADY12792.1 ADY12792.1 leuB leuB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
ADY12623.1D-lactate dehydrogenase; KEGG: cpy:Cphy_1923 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (341 aa)
ADY12551.1Phosphoglycerate dehydrogenase; KEGG: cpy:Cphy_1465 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (326 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa)
ADY12461.1KEGG: ssm:Spirs_0987 malic protein NAD-binding protein; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; SMART: Malic enzyme, NAD-binding. (431 aa)
ADY12403.1KEGG: hdn:Hden_3452 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; PFAM: Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal; Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (322 aa)
ADY12375.1Alcohol dehydrogenase; KEGG: bpo:BP951000_0786 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (389 aa)
ADY12367.16-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (481 aa)
ADY12365.1L-iditol 2-dehydrogenase; KEGG: ssm:Spirs_3602 alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal. (344 aa)
ADY12329.1KEGG: bcv:Bcav_1503 glycerol-1-phosphate dehydrogenase (NAD(P)(+)); PFAM: 3-dehydroquinate synthase AroB. (428 aa)
ADY12271.1Alpha-galactosidase; KEGG: cbe:Cbei_4359 glycoside hydrolase family protein; PFAM: Glycoside hydrolase, family 4. (439 aa)
ADY12255.1TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: dae:Dtox_4079 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal. (430 aa)
ADY12253.1KEGG: avn:Avin_27360 mannitol dehydrogenase; PFAM: Mannitol dehydrogenase, C-terminal; Mannitol dehydrogenase, N-terminal. (477 aa)
ADY12223.1dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (299 aa)
ADY12216.1dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (299 aa)
ADY12188.1L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; KEGG: amt:Amet_0554 alcohol dehydrogenase; SMART: Polyketide synthase, enoylreductase. (345 aa)
ADY12166.1KEGG: bbe:BBR47_56360 mannitol-1-phosphate 5-dehydrogenase; PFAM: Mannitol dehydrogenase, C-terminal; Mannitol dehydrogenase, N-terminal. (394 aa)
ADY14816.1KEGG: cbe:Cbei_1833 altronate oxidoreductase; PFAM: Mannitol dehydrogenase, C-terminal; Bile acid:sodium symporter; Mannitol dehydrogenase, N-terminal. (816 aa)
ADY14787.14-hydroxythreonine-4-phosphate dehydrogenase; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: dhd:Dhaf_1967 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; Belongs to the PdxA family. (335 aa)
ADY14775.1PFAM: 3-dehydroquinate synthase AroB; KEGG: ipo:Ilyop_0504 iron-containing alcohol dehydrogenase. (425 aa)
ADY14543.1Alpha-galactosidase; KEGG: bpo:BP951000_0253 alpha-galactosidase/6-phospho-beta-glucosidase; PFAM: Glycoside hydrolase, family 4. (451 aa)
ADY14525.1Alcohol dehydrogenase; KEGG: tau:Tola_2293 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (384 aa)
ADY14523.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa)
ADY14478.1KEGG: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (368 aa)
ADY14443.1Alpha-galactosidase; KEGG: csc:Csac_2748 glycoside hydrolase family protein; PFAM: Glycoside hydrolase, family 4. (447 aa)
ADY14382.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (338 aa)
ADY12101.1TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: elm:ELI_2699 UDP-glucose/GDP-mannose dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (431 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (294 aa)
ADY12019.1Phosphoglycerate dehydrogenase; KEGG: ssm:Spirs_2574 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (318 aa)
ADY14361.1KEGG: clj:CLJU_c30120 phosphoglycerate dehydrogenase-like protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (321 aa)
ADY14088.1Alcohol dehydrogenase; KEGG: cti:RALTA_B0680 putative alcool deshydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (389 aa)
ADY14073.1KEGG: cpy:Cphy_1062 mannitol dehydrogenase domain-containing protein; PFAM: Mannitol dehydrogenase, C-terminal; Mannitol dehydrogenase, N-terminal. (534 aa)
ADY14040.1Alcohol dehydrogenase zinc-binding domain protein; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; KEGG: csc:Csac_0869 alcohol dehydrogenase. (424 aa)
ADY14034.1L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; KEGG: sus:Acid_2859 alcohol dehydrogenase; SMART: Polyketide synthase, enoylreductase. (355 aa)
ADY13876.1PFAM: Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: tde:TDE0353 GDSL family lipase/acylhydrolase. (319 aa)
ADY13784.14-hydroxythreonine-4-phosphate dehydrogenase; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: fnu:FN0226 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; Belongs to the PdxA family. (342 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (305 aa)
ADY13467.1Phosphoglycerate dehydrogenase; KEGG: ssm:Spirs_2138 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (294 aa)
ADY13455.14-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: ipo:Ilyop_0077 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (322 aa)
ADY13292.1KEGG: elm:ELI_1158 IMP dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core. (502 aa)
ADY13147.1KEGG: has:Halsa_0822 glucose-6-phosphate 1-dehydrogenase; PFAM: Glucose-6-phosphate dehydrogenase, C-terminal; Glucose-6-phosphate dehydrogenase, NAD-binding. (457 aa)
aroE-23-dehydroquinate dehydratase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (494 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (371 aa)
ADY13017.1KEGG: oih:OB2167 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (409 aa)
ADY12979.1KEGG: cbe:Cbei_1932 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (399 aa)
ADY12792.1Acetaldehyde dehydrogenase (acetylating); KEGG: kva:Kvar_1983 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (887 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (352 aa)
Your Current Organism:
Sphaerochaeta globosa
NCBI taxonomy Id: 158189
Other names: S. globosa str. Buddy, Sphaerochaeta globosa str. Buddy, Sphaerochaeta sp. Buddy, Spirochaeta sp. Buddy
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