STRINGSTRING
ADY13270.1 ADY13270.1 rlmE rlmE rsmI rsmI ADY14738.1 ADY14738.1 ADY14730.1 ADY14730.1 ADY14682.1 ADY14682.1 ADY14629.1 ADY14629.1 ADY14620.1 ADY14620.1 ADY14560.1 ADY14560.1 ADY14429.1 ADY14429.1 ADY14189.1 ADY14189.1 ADY14104.1 ADY14104.1 ADY13970.1 ADY13970.1 ADY13939.1 ADY13939.1 glyA glyA prmC prmC ADY13866.1 ADY13866.1 gcvT gcvT ADY13826.1 ADY13826.1 ADY13817.1 ADY13817.1 rsmA rsmA ADY13747.1 ADY13747.1 ADY13692.1 ADY13692.1 ADY13636.1 ADY13636.1 ADY13618.1 ADY13618.1 ADY13327.1 ADY13327.1 ADY13317.1 ADY13317.1 ADY13310.1 ADY13310.1 trmD trmD rsmH rsmH trmB trmB ADY13006.1 ADY13006.1 purU purU ADY12706.1 ADY12706.1 rsmG rsmG ADY12636.1 ADY12636.1 rlmL rlmL thyX thyX ADY12599.1 ADY12599.1 ADY12383.1 ADY12383.1 accA accA accD accD ADY11980.1 ADY11980.1 ADY11880.1 ADY11880.1 ADY11867.1 ADY11867.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ADY13270.1methylated-DNA/protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (160 aa)
rlmERibosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (208 aa)
rsmIRibosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (237 aa)
ADY14738.1PFAM: tRNA/rRNA methyltransferase, SpoU; KEGG: ssm:Spirs_0318 tRNA/rRNA methyltransferase (SpoU). (266 aa)
ADY14730.1Methyltransferase; KEGG: ssm:Spirs_1324 methyltransferase; TIGRFAM: RNA methyltransferase, RsmD; PFAM: RNA methyltransferase, RsmD. (186 aa)
ADY14682.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (333 aa)
ADY14629.1KEGG: sta:STHERM_c13010 hemolysin; TIGRFAM: Haemolysin A; PFAM: Ribosomal RNA methyltransferase RrmJ/FtsJ. (258 aa)
ADY14620.1KEGG: ssm:Spirs_3194 RNA methyltransferase, TrmH family, group 3; TIGRFAM: RNA methyltransferase TrmH, group 3; PFAM: tRNA/rRNA methyltransferase, SpoU; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (251 aa)
ADY14560.1PFAM: Uncharacterised protein family UPF0066; KEGG: ssm:Spirs_4222 protein of unknown function UPF0066. (155 aa)
ADY14429.1TIGRFAM: C-5 cytosine methyltransferase; KEGG: cpf:CPF_1017 DNA-cytosine methyltransferase; PFAM: C-5 cytosine methyltransferase. (402 aa)
ADY14189.1PFAM: DNA methylase N-4/N-6; KEGG: sfu:Sfum_2856 DNA methylase N-4/N-6 domain-containing protein. (932 aa)
ADY14104.1Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (314 aa)
ADY13970.1Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; KEGG: bvu:BVU_1693 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain. (385 aa)
ADY13939.1Radical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. (361 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (509 aa)
prmCprotein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (286 aa)
ADY13866.1KEGG: ppn:Palpr_0704 hypothetical protein. (283 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
ADY13826.1TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; KEGG: tde:TDE0129 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Aspartate carbamoyltransferase regulatory subunit, N-terminal; Aspartate carbamoyltransferase regulatory subunit, C-terminal. (534 aa)
ADY13817.1Manually curated; KEGG: phe:Phep_4225 PUA domain containing protein. (408 aa)
rsmARibosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (292 aa)
ADY13747.1rRNA (guanine-N(2)-)-methyltransferase; KEGG: ske:Sked_22180 hypothetical protein. (879 aa)
ADY13692.1KEGG: bfr:BF1980 helicase domain-containing protein; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; Restriction endonuclease, type IV-like, Mrr; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal. (1632 aa)
ADY13636.1TIGRFAM: Probable carbamoyltransferase YgeW; KEGG: ssm:Spirs_1395 carbamoyltransferase YgeW; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (399 aa)
ADY13618.1tRNA/rRNA methyltransferase (SpoU); Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (166 aa)
ADY13327.1Gp37Gp68 family protein; PFAM: Phage Gp37Gp68; KEGG: elm:ELI_3917 hypothetical protein. (300 aa)
ADY13317.1PFAM: Methyltransferase type 11; KEGG: cbt:CLH_2444 methyltransferase. (257 aa)
ADY13310.1KEGG: DNA-cytosine methyltransferase; TIGRFAM: C-5 cytosine methyltransferase; PFAM: C-5 cytosine methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (516 aa)
trmDtRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (250 aa)
rsmHRibosomal RNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (296 aa)
trmBtRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (245 aa)
ADY13006.1PFAM: Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p; KEGG: ssm:Spirs_2381 Fmu (Sun) domain protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (262 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (290 aa)
ADY12706.1PFAM: tRNA/rRNA methyltransferase, SpoU; KEGG: ssm:Spirs_2304 RNA methyltransferase, TrmH family, group 1. (247 aa)
rsmGRibosomal RNA small subunit methyltransferase G; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (219 aa)
ADY12636.1PFAM: (Uracil-5)-methyltransferase; KEGG: tde:TDE2619 RNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (383 aa)
rlmLrRNA (guanine-N(2)-)-methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (743 aa)
thyXThymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (273 aa)
ADY12599.1Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (239 aa)
ADY12383.1PFAM: Methyltransferase type 11; KEGG: tte:TTE0594 SAM-dependent methyltransferase. (204 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (305 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (256 aa)
ADY11980.1KEGG: csh:Closa_2855 RNA methyltransferase, TrmA family; TIGRFAM: 23S rRNA methyltransferase/RumA; PFAM: (Uracil-5)-methyltransferase; DNA methylase N-4/N-6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (390 aa)
ADY11880.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1171 aa)
ADY11867.1Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (263 aa)
Your Current Organism:
Sphaerochaeta globosa
NCBI taxonomy Id: 158189
Other names: S. globosa str. Buddy, Sphaerochaeta globosa str. Buddy, Sphaerochaeta sp. Buddy, Spirochaeta sp. Buddy
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