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| | ADY14749.1 | SMART: Methylglyoxal synthase-like domain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: sta:STHERM_c07390 carbamoyl-phosphate synthase large chain; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Belongs to the CarB family. (1069 aa) |
| | ADY11871.1 | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (548 aa) |
| | ADY11878.1 | PFAM: Domain of unknown function DUF39; KEGG: tle:Tlet_1363 hypothetical protein. (386 aa) |
| | ADY11880.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1171 aa) |
| | ADY11882.1 | TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; KEGG: ssm:Spirs_0275 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; Prephenate dehydratase; Amino acid-binding ACT. (636 aa) |
| | leuS | TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial; KEGG: ssm:Spirs_0283 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (842 aa) |
| | ADY11896.1 | KEGG: gym:GYMC10_2999 Asp/Glu/hydantoin racemase. (222 aa) |
| | ADY11905.1 | PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; Signal transduction response regulator, receiver domain; KEGG: ssm:Spirs_3995 response regulator receiver protein. (979 aa) |
| | ADY11906.1 | PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; KEGG: ssm:Spirs_3994 glutamate dehydrogenase (NADP(+)); SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa) |
| | ADY11930.1 | Hypothetical protein. (67 aa) |
| | ADY11948.1 | KEGG: cce:Ccel_1104 hypothetical protein. (326 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | ADY11953.1 | PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; KEGG: cth:Cthe_0202 L-glutamine synthetase. (426 aa) |
| | ADY11954.1 | PFAM: Glutamate synthase, alpha subunit, C-terminal; KEGG: cth:Cthe_0201 glutamate synthase (NADPH) GltB3 subunit. (241 aa) |
| | ADY11957.1 | KEGG: cth:Cthe_0198 glutamate synthase (NADPH) GltB2 subunit; PFAM: Glutamate synthase, central-C; 4Fe-4S binding domain. (501 aa) |
| | ADY11958.1 | PFAM: Glutamine amidotransferase, class-II; KEGG: cth:Cthe_0197 glutamate synthase (NADPH) GltB1 subunit. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | argD | PFAM: Aminotransferase class-III; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: elm:ELI_2182 hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (398 aa) |
| | ADY11969.1 | TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; KEGG: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (558 aa) |
| | ADY11979.1 | KEGG: pmo:Pmob_0980 5-carboxymethyl-2-hydroxymuconate delta-isomerase; PFAM: Fumarylacetoacetase, C-terminal-like; Domain of unknown function DUF2437. (250 aa) |
| | ADY12004.1 | PFAM: Peptidase M20; Peptidase M20, dimerisation; KEGG: mta:Moth_0710 peptidase. (383 aa) |
| | ADY12015.1 | KEGG: bfs:BF3383 hypothetical protein. (710 aa) |
| | ADY12020.1 | KEGG: pen:PSEEN1035 ornithine decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2, N-terminal; Orn/DAP/Arg decarboxylase 2, C-terminal; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (397 aa) |
| | ADY12022.1 | KEGG: ssm:Spirs_0510 dihydrodipicolinate synthetase; HAMAP: Dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (300 aa) |
| | ADY12030.1 | SMART: SAF domain; TIGRFAM: Galactarate dehydratase; KEGG: afn:Acfer_0082 galactarate dehydratase; PFAM: D-galactarate dehydratase/Altronate hydrolase, C-terminal; SAF domain. (502 aa) |
| | ADY12034.1 | PFAM: Glucosamine/galactosamine-6-phosphate isomerase; KEGG: phe:Phep_0774 glucosamine-6-phosphate deaminase. (248 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (341 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (294 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (302 aa) |
| | ADY12110.1 | KEGG: tde:TDE1413 cytidylyltransferase/phosphoenolpyruvate phosphomutase, putative; TIGRFAM: Phosphoenolpyruvate phosphomutase, core; Cytidyltransferase-related; PFAM: Cytidylyltransferase. (432 aa) |
| | ADY12180.1 | HpcH/HpaI aldolase; PFAM: Aldehyde-lyase domain; KEGG: cdl:CDR20291_1924 hypothetical protein; Belongs to the HpcH/HpaI aldolase family. (257 aa) |
| | ADY12188.1 | L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal; KEGG: amt:Amet_0554 alcohol dehydrogenase; SMART: Polyketide synthase, enoylreductase. (345 aa) |
| | ADY12201.1 | HpcH/HpaI aldolase; PFAM: Aldehyde-lyase domain; KEGG: elm:ELI_1798 HpcH/HpaI aldolase/citrate lyase family protein; Belongs to the HpcH/HpaI aldolase family. (279 aa) |
| | ADY12202.1 | Diaminopimelate decarboxylase; KEGG: elm:ELI_1799 putative pyridoxal-dependent decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2, N-terminal. (400 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa) |
| | ADY12255.1 | TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: dae:Dtox_4079 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal. (430 aa) |
| | ADY12273.1 | PFAM: Aminoglycoside phosphotransferase; KEGG: cpf:CPF_1410 MdsC protein. (360 aa) |
| | ADY12293.1 | PFAM: Class II aldolase/adducin, N-terminal; KEGG: mmw:Mmwyl1_2551 putative aldolase. (206 aa) |
| | fabV | Reductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (403 aa) |
| | ADY12301.1 | PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ; KEGG: sta:STHERM_c08550 beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ. (145 aa) |
| | ADY12302.1 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (417 aa) |
| | ADY12304.1 | (Acyl-carrier-protein) S-malonyltransferase; KEGG: sta:STHERM_c21550 hypothetical protein; SMART: Polyketide synthase, acyl transferase domain. (313 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa) |
| | ADY12306.1 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (142 aa) |
| | ADY12307.1 | Pyruvate carboxylase; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal; KEGG: sta:STHERM_c08570 pyruvate carboxylase subunit A; SMART: Biotin carboxylase, C-terminal. (443 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (256 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (305 aa) |
| | ADY12312.1 | KEGG: cpb:Cphamn1_2546 hypothetical protein. (281 aa) |
| | ADY12326.1 | D-lactate dehydrogenase (cytochrome); KEGG: amt:Amet_3747 FAD linked oxidase domain-containing protein; PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal. (472 aa) |
| | ADY12334.1 | Beta-lactamase domain protein; SMART: Beta-lactamase-like; KEGG: csh:Closa_4139 hypothetical protein. (234 aa) |
| | ADY12358.1 | PFAM: Asparaginase/glutaminase; KEGG: ade:Adeh_2142 asparaginase. (167 aa) |
| | ADY12365.1 | L-iditol 2-dehydrogenase; KEGG: ssm:Spirs_3602 alcohol dehydrogenase GroES domain protein; PFAM: Alcohol dehydrogenase GroES-like; Alcohol dehydrogenase, C-terminal. (344 aa) |
| | ADY12367.1 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (481 aa) |
| | ADY12405.1 | KEGG: sss:SSUSC84_0197 glucosamine-6-phosphate isomerase; PFAM: Glucosamine/galactosamine-6-phosphate isomerase. (277 aa) |
| | ADY12407.1 | KEGG: dhd:Dhaf_2635 triosephosphate isomerase; PFAM: Triosephosphate isomerase. (286 aa) |
| | ADY12411.1 | PFAM: Phosphoglucose isomerase (PGI); KEGG: gmc:GY4MC1_3102 glucose-6-phosphate isomerase. (426 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (391 aa) |
| | ADY12416.1 | TIGRFAM: Ketose-bisphosphate aldolase, class-II; KEGG: drt:Dret_1398 fructose-1,6-bisphosphate aldolase, class II; PFAM: Ketose-bisphosphate aldolase, class-II. (385 aa) |
| | ADY12461.1 | KEGG: ssm:Spirs_0987 malic protein NAD-binding protein; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; SMART: Malic enzyme, NAD-binding. (431 aa) |
| | ADY12467.1 | KEGG: ssm:Spirs_0879 alanyl-tRNA synthetase, class IIc; PFAM: Alanyl-tRNA synthetase, class IIc, N-terminal; Threonyl/alanyl tRNA synthetase, SAD; SMART: Threonyl/alanyl tRNA synthetase, SAD. (394 aa) |
| | ADY12477.1 | KEGG: cpe:CPE0924 metallo-beta-lactamase family protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (274 aa) |
| | ADY12488.1 | Pyruvate dehydrogenase (acetyl-transferring); PFAM: Dehydrogenase, E1 component; Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; KEGG: fri:FraEuI1c_5335 dehydrogenase E1 component; SMART: Transketolase-like, pyrimidine-binding domain. (658 aa) |
| | pheS | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain 2, bacterial/archaeal; KEGG: ssm:Spirs_4136 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (512 aa) |
| | ADY12490.1 | SMART: tRNA synthetase, B5; B3/B4 tRNA-binding domain; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic; KEGG: sta:STHERM_c21760 phenylalanyl-tRNA synthetase subunit beta; PFAM: tRNA synthetase, B5. (565 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa) |
| | hisC | PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: cpi:Cpin_1819 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | hisB | PFAM: Imidazoleglycerol-phosphate dehydratase; TIGRFAM: Histidinol-phosphatase; Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: chu:CHU_1270 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (375 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: fjo:Fjoh_2873 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis. (244 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | hisI | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: sli:Slin_5481 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like; Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (202 aa) |
| | ADY12539.1 | HpcH/HpaI aldolase; PFAM: Aldehyde-lyase domain; KEGG: dhd:Dhaf_2073 HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (251 aa) |
| | ADY12550.1 | 2-dehydro-3-deoxyglucarate aldolase; KEGG: xbo:XBJ1_0873 putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, with PEP/pyruvate domain; PFAM: Aldehyde-lyase domain; Belongs to the HpcH/HpaI aldolase family. (259 aa) |
| | ADY12554.1 | KEGG: ssm:Spirs_0510 dihydrodipicolinate synthetase; HAMAP: Dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (300 aa) |
| | ADY12571.1 | KEGG: aoe:Clos_0355 beta-lactamase domain-containing protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (230 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | ADY12595.1 | PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: ssm:Spirs_4117 4-diphosphocytidyl-2C-methyl-D-erythritolsynthas E. (270 aa) |
| | ADY12641.1 | KEGG: ssm:Spirs_3682 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (257 aa) |
| | ADY12645.1 | Lysine 2,3-aminomutase YodO family protein; TIGRFAM: Conserved hyprothetical protein CHP00238, KamA; KEGG: tte:TTE0723 lysine 2,3-aminomutase; PFAM: Radical SAM. (363 aa) |
| | ADY12659.1 | Lysine--tRNA ligase; KEGG: ssm:Spirs_3665 tRNA synthetase class II (D K and N); PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Belongs to the class-II aminoacyl-tRNA synthetase family. (330 aa) |
| | ADY12664.1 | D-amino-acid transaminase; KEGG: ssm:Spirs_0479 aminotransferase class IV; PFAM: Aminotransferase, class IV. (270 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | ADY12675.1 | KEGG: ssm:Spirs_0574 aspartate kinase; TIGRFAM: Aspartate kinase domain; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (435 aa) |
| | ADY12694.1 | KEGG: ssm:Spirs_3695 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase. (640 aa) |
| | ADY12699.1 | UPF0597 protein yhaM; HAMAP: Uncharacterised protein family UPF0597; KEGG: ssm:Spirs_2717 protein of unknown function DUF1063; Belongs to the UPF0597 family. (424 aa) |
| | nagB | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (270 aa) |
| | ADY12714.1 | KEGG: sta:STHERM_c21790 hypothetical protein; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase-like hydrolase. (201 aa) |
| | ADY12720.1 | KEGG: ssm:Spirs_0466 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (215 aa) |
| | ADY12778.1 | KEGG: ate:Athe_0503 acetolactate synthase small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (176 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (537 aa) |
| | ADY12781.1 | SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase-related; KEGG: str:Sterm_0108 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (352 aa) |
| | ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: amt:Amet_3401 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (561 aa) |
| | ADY12786.1 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: cpy:Cphy_3347 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (560 aa) |
| | ADY12819.1 | PFAM: Domain of unknown function DUF1508; KEGG: elm:ELI_4348 protein YegP. (128 aa) |
| | ADY12822.1 | TIGRFAM: Diaminopropionate ammonia-lyase; KEGG: ctc:CTC00071 diaminopropionate ammonia-lyase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (414 aa) |
| | ADY12849.1 | TIGRFAM: Branched-chain amino acid aminotransferase II; KEGG: eel:EUBELI_01912 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV. (341 aa) |
| | ADY12867.1 | PFAM: Glucosamine/galactosamine-6-phosphate isomerase; KEGG: phe:Phep_0774 glucosamine-6-phosphate deaminase. (247 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (404 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (287 aa) |
| | ADY12946.1 | TIGRFAM: Dihydrodipicolinate reductase, bacterial/plant; KEGG: sta:STHERM_c08680 dihydrodipicolinate reductase; PFAM: Dihydrodipicolinate reductase, C-terminal; Dihydrodipicolinate reductase, N-terminal; Belongs to the DapB family. (253 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (409 aa) |
| | ADY12949.1 | KEGG: ssm:Spirs_1460 Orn/DAP/Arg decarboxylase 2; PFAM: Orn/DAP/Arg decarboxylase 2, C-terminal; Orn/DAP/Arg decarboxylase 2, N-terminal. (421 aa) |
| | ADY12980.1 | KEGG: cce:Ccel_2993 protein of unknown function DUF1121. (226 aa) |
| | asnA | PFAM: Aspartate--ammonia ligase; TIGRFAM: Aspartate--ammonia ligase; HAMAP: Aspartate--ammonia ligase; KEGG: pdi:BDI_3717 asparagine synthetase AsnA. (344 aa) |
| | ADY13017.1 | KEGG: oih:OB2167 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (409 aa) |
| | argG | PFAM: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: tma:TM1780 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | ADY13025.1 | PFAM: Haloacid dehalogenase-like hydrolase. (223 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (741 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (371 aa) |
| | aroE-2 | 3-dehydroquinate dehydratase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (494 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (349 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | ADY13115.1 | TIGRFAM: Pyruvate, phosphate dikinase; KEGG: rmr:Rmar_0942 pyruvate, phosphate dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile domain; PEP-utilising enzyme; Belongs to the PEP-utilizing enzyme family. (903 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1042 aa) |
| | ADY13142.1 | TIGRFAM: Tryptophanyl-tRNA synthetase, class Ib; KEGG: cpy:Cphy_3480 tryptophanyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ib. (330 aa) |
| | ADY13153.1 | KEGG: ssm:Spirs_1902 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase AroB. (379 aa) |
| | hisS | PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; KEGG: ssm:Spirs_1904 histidyl-tRNA synthetase. (444 aa) |
| | ADY13180.1 | KEGG: tde:TDE1502 chorismate mutase; TIGRFAM: Chorismate mutase, AroH class; PFAM: Chorismate mutase, AroH class. (122 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (599 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa) |
| | pgk | HAMAP: Phosphoglycerate kinase; KEGG: sta:STHERM_c09800 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase. (392 aa) |
| | ADY13261.1 | SMART: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: ssm:Spirs_2445 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (347 aa) |
| | ADY13286.1 | Beta-lactamase domain protein; KEGG: ssm:Spirs_2469 hypothetical protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (202 aa) |
| | ADY13321.1 | Agmatinase; TIGRFAM: Putative agmatinase; KEGG: dds:Ddes_0074 agmatinase; PFAM: Ureohydrolase; Belongs to the arginase family. (285 aa) |
| | ADY13322.1 | KEGG: syn:sll0873 carboxynorspermidine decarboxylase; TIGRFAM: Carboxynorspermidine decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2, C-terminal. (371 aa) |
| | ADY13324.1 | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (637 aa) |
| | ADY13359.1 | S-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (257 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (357 aa) |
| | ADY13396.1 | 2,4-diaminobutyrate 4-transaminase; TIGRFAM: Diaminobutyrate-2-oxoglutarate transaminase; KEGG: aci:ACIAD1210 diaminobutyrate--2-oxoglutarate aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa) |
| | ADY13397.1 | KEGG: bpu:BPUM_1020 diaminobutyrate decarboxylase; PFAM: Pyridoxal phosphate-dependent decarboxylase. (485 aa) |
| | ADY13400.1 | PFAM: Protein of unknown function DUF161; KEGG: aco:Amico_1695 protein of unknown function DUF161. (219 aa) |
| | ADY13415.1 | Alcohol dehydrogenase zinc-binding domain protein; KEGG: esi:Exig_1460 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; SMART: Polyketide synthase, enoylreductase. (307 aa) |
| | ADY13429.1 | KEGG: sme:SM_b20299 N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase. (295 aa) |
| | ADY13473.1 | TIGRFAM: Bacterial carbamate kinase; KEGG: bbe:BBR47_45090 carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (314 aa) |
| | ADY13479.1 | PFAM: Dihydrodipicolinate synthetase; TIGRFAM: Dihydrodipicolinate synthase subfamily; HAMAP: Dihydrodipicolinate synthase; KEGG: ant:Arnit_1025 dihydrodipicolinate synthase; Belongs to the DapA family. (298 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (882 aa) |
| | cysS | TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; KEGG: sta:STHERM_c18260 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (471 aa) |
| | ADY13499.1 | KEGG: vpr:Vpar_0342 cysteine desulfurase family protein; PFAM: Aminotransferase, class V/Cysteine desulfurase. (374 aa) |
| | ADY13535.1 | TIGRFAM: Threonine synthase; KEGG: threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (422 aa) |
| | ADY13536.1 | TIGRFAM: Aspartate kinase domain; KEGG: ssm:Spirs_2770 aspartate kinase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT. (798 aa) |
| | ADY13556.1 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: cpy:Cphy_0010 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (432 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa) |
| | ADY13558.1 | KEGG: transcriptional regulator, MarR family; PFAM: Nucleoside phosphorylase domain. (235 aa) |
| | ADY13559.1 | TIGRFAM: Initiation factor 2B alpha/beta/delta; KEGG: ssm:Spirs_3887 eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2B-related; Belongs to the eIF-2B alpha/beta/delta subunits family. (339 aa) |
| | ADY13570.1 | TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; KEGG: cce:Ccel_3186 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (309 aa) |
| | ADY13576.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa) |
| | ADY13577.1 | KEGG: ssm:Spirs_2245 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase. (607 aa) |
| | ADY13578.1 | KEGG: gur:Gura_2063 beta-lactamase domain-containing protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (257 aa) |
| | ADY13580.1 | KEGG: ssm:Spirs_1501 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase. (639 aa) |
| | asnS | PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; TIGRFAM: Asparaginyl-tRNA synthetase, class IIb; HAMAP: Asparaginyl-tRNA synthetase, class IIb; KEGG: ssm:Spirs_2248 asparaginyl-tRNA synthetase. (462 aa) |
| | pfp-2 | Diphosphate/fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (552 aa) |
| | ADY13599.1 | KEGG: ssm:Spirs_2267 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase. (579 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (271 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (442 aa) |
| | ADY13636.1 | TIGRFAM: Probable carbamoyltransferase YgeW; KEGG: ssm:Spirs_1395 carbamoyltransferase YgeW; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (399 aa) |
| | ADY13640.1 | Putative selenium metabolism hydrolase; KEGG: ssm:Spirs_1388 M20/DapE family protein YgeY; TIGRFAM: putative selenium metabolism hydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (405 aa) |
| | ADY13643.1 | PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; KEGG: ssm:Spirs_1385 pyridoxal-5'-phosphate-dependent protein beta subunit. (489 aa) |
| | ADY13644.1 | Threonine synthase; KEGG: ssm:Spirs_1384 pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (407 aa) |
| | ADY13714.1 | TIGRFAM: Fructose-1,6-bisphosphate aldolase, class 2; Ketose-bisphosphate aldolase, class-II; KEGG: ssm:Spirs_2588 fructose-1,6-bisphosphate aldolase, class II; PFAM: Ketose-bisphosphate aldolase, class-II. (330 aa) |
| | glnS | PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; Glutamyl/glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain; TIGRFAM: Glutaminyl-tRNA synthetase, class Ic; HAMAP: Glutaminyl-tRNA synthetase, bacterial; KEGG: ssm:Spirs_1481 glutaminyl-tRNA synthetase. (562 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (294 aa) |
| | ADY13765.1 | KEGG: ssm:Spirs_3134 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase. (569 aa) |
| | mtnA-2 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (345 aa) |
| | ADY13768.1 | PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain; KEGG: aba:Acid345_0942 glutamate dehydrogenase; SMART: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (453 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (418 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (443 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (494 aa) |
| | argS | KEGG: ssm:Spirs_1801 arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic; HAMAP: Arginyl-tRNA synthetase, class Ic. (587 aa) |
| | ADY13806.1 | KEGG: ssm:Spirs_1684 serine O-acetyltransferase. (308 aa) |
| | ADY13809.1 | Arogenate dehydrogenase (NADP(+)); Manually curated; KEGG: ssm:Spirs_1513 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (252 aa) |
| | ADY13826.1 | TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; KEGG: tde:TDE0129 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Aspartate carbamoyltransferase regulatory subunit, N-terminal; Aspartate carbamoyltransferase regulatory subunit, C-terminal. (534 aa) |
| | ADY13834.1 | Hypothetical protein; KEGG: chu:CHU_0232 antifreeze-related protein. (560 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa) |
| | ADY13851.1 | TIGRFAM: Argininosuccinate lyase; KEGG: ssm:Spirs_3701 argininosuccinate lyase; PFAM: Lyase 1, N-terminal. (457 aa) |
| | ADY13860.1 | KEGG: ssm:Spirs_4169 beta-lactamase domain-containing protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (253 aa) |
| | ADY13865.1 | PFAM: Class II aldolase/adducin, N-terminal; KEGG: pjd:Pjdr2_1890 class II aldolase/adducin family protein. (358 aa) |
| | ADY13876.1 | PFAM: Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: tde:TDE0353 GDSL family lipase/acylhydrolase. (319 aa) |
| | ADY13892.1 | PFAM: Nucleoside phosphorylase domain; KEGG: sta:STHERM_c12670 MTA/SAH nucleosidase. (222 aa) |
| | ADY13896.1 | Hexokinase; KEGG: ssm:Spirs_3985 hexokinase; PFAM: Hexokinase, N-terminal; Hexokinase, C-terminal. (436 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (394 aa) |
| | ADY13913.1 | KEGG: ssm:Spirs_2132 glycine cleavage system P-protein. (483 aa) |
| | ADY13914.1 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (451 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (509 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (598 aa) |
| | ADY13964.1 | TIGRFAM: Glutamate synthase (NADPH), homotetrameric; KEGG: ssm:Spirs_1641 glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (495 aa) |
| | ADY13968.1 | TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; KEGG: mla:Mlab_0300 carbamoyl-phosphate synthase, large subunit; PFAM: AIR synthase-related protein, C-terminal. (1215 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (466 aa) |
| | ADY13976.1 | KEGG: shi:Shel_01840 C_GCAxxG_C_C family probable redox protein; TIGRFAM: CGCAxxGCC motif; PFAM: CGCAxxGCC motif. (141 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa) |
| | ADY14008.1 | KEGG: gym:GYMC10_0510 dihydrodipicolinate synthetase; Belongs to the DapA family. (355 aa) |
| | ADY14010.1 | Amidohydrolase; KEGG: aar:Acear_1192 amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation; Belongs to the peptidase M20A family. (427 aa) |
| | ADY14027.1 | KEGG: ssm:Spirs_3940 threonine aldolase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase. (341 aa) |
| | ADY14033.1 | KEGG: sus:Acid_2860 aldehyde reductase; PFAM: NADP-dependent oxidoreductase domain. (336 aa) |
| | ADY14034.1 | L-iditol 2-dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; KEGG: sus:Acid_2859 alcohol dehydrogenase; SMART: Polyketide synthase, enoylreductase. (355 aa) |
| | ADY14040.1 | Alcohol dehydrogenase zinc-binding domain protein; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; KEGG: csc:Csac_0869 alcohol dehydrogenase. (424 aa) |
| | ADY14045.1 | Dihydrolipoyllysine-residue acetyltransferase; KEGG: ckn:Calkro_1928 catalytic domain-containing protein of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; E3 binding; Biotin/lipoyl attachment. (437 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | ADY14070.1 | Glucosamine-6-phosphate deaminase; KEGG: sno:Snov_4298 glucosamine/galactosamine-6-phosphate isomerase; PFAM: Glucosamine/galactosamine-6-phosphate isomerase. (248 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (358 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (125 aa) |
| | lysS | PFAM: Lysyl-tRNA synthetase, class Ic; TIGRFAM: Lysyl-tRNA synthetase, class I; HAMAP: Lysyl-tRNA synthetase, class I, archaeal-type; KEGG: ssm:Spirs_3699 lysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (524 aa) |
| | ADY14234.1 | KEGG: htu:Htur_1435 lactoylglutathione lyase-like protein. (159 aa) |
| | ADY14236.1 | KEGG: cwo:Cwoe_2271 hypothetical protein. (177 aa) |
| | ADY14248.1 | Beta-lactamase domain protein; KEGG: mac:MA2009 beta-lactamase; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (226 aa) |
| | ADY14283.1 | Beta-lactamase domain protein; PFAM: Beta-lactamase-like; KEGG: sli:Slin_6275 hypothetical protein. (281 aa) |
| | ADY14284.1 | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (330 aa) |
| | ADY14290.1 | KEGG: tgr:Tgr7_2455 dihydrolipoyllysine-residue succinyltransferase; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding. (436 aa) |
| | ADY14291.1 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (888 aa) |
| | anmK | Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (409 aa) |
| | murQ-2 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (311 aa) |
| | ADY14349.1 | Fumarate hydratase class II; PFAM: Lyase 1, N-terminal; Fumarase C, C-terminal; TIGRFAM: Aspartate ammonia-lyase; HAMAP: Fumarate hydratase, class II; KEGG: ade:Adeh_1757 aspartate ammonia-lyase. (463 aa) |
| | ADY14382.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (338 aa) |
| | ADY14389.1 | Lysine 2,3-aminomutase YodO family protein; TIGRFAM: Conserved hyprothetical protein CHP00238, KamA; KEGG: dat:HRM2_13250 KamA2; PFAM: Radical SAM. (421 aa) |
| | ADY14414.1 | Propanoyl-CoA C-acyltransferase; KEGG: clj:CLJU_c23630 putative acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa) |
| | ADY14416.1 | Cyclase family protein; PFAM: Putative cyclase; KEGG: hypothetical protein. (291 aa) |
| | ADY14449.1 | PFAM: Amidohydrolase 2; KEGG: ssa:SSA_2083 hypothetical protein. (299 aa) |
| | ADY14476.1 | PFAM: Asp/Glu/hydantoin racemase; KEGG: rlt:Rleg2_5297 hypothetical protein. (220 aa) |
| | ADY14478.1 | KEGG: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (368 aa) |
| | ADY14512.1 | PFAM: Dihydrodipicolinate synthetase; KEGG: gym:GYMC10_3581 dihydrodipicolinate synthetase; Belongs to the DapA family. (307 aa) |
| | ADY14513.1 | KEGG: pcl:Pcal_1422 2-dehydro-3-deoxyglucarate aldolase; PFAM: Aldehyde-lyase domain; Belongs to the HpcH/HpaI aldolase family. (255 aa) |
| | ADY14523.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | ADY14534.1 | SMART: Semialdehyde dehydrogenase, NAD-binding; TIGRFAM: Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking; KEGG: ssm:Spirs_4027 aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD-binding; Semialdehyde dehydrogenase, dimerisation domain; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | ADY14555.1 | PFAM: Haloacid dehalogenase-like hydrolase. (245 aa) |
| | ADY14567.1 | TIGRFAM: Pyruvate kinase; KEGG: hor:Hore_03220 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; Belongs to the pyruvate kinase family. (477 aa) |
| | ADY14679.1 | Gly-Xaa carboxypeptidase; KEGG: mxa:MXAN_2289 hypothetical protein; PFAM: Peptidase M20; Peptidase M20, dimerisation. (477 aa) |
| | ADY14682.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (333 aa) |
| | thrS | TIGRFAM: Threonyl-tRNA synthetase, class IIa; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Threonyl/alanyl tRNA synthetase, SAD; Anticodon-binding; KEGG: ssm:Spirs_3229 threonyl-tRNA synthetase; SMART: Threonyl/alanyl tRNA synthetase, SAD; Belongs to the class-II aminoacyl-tRNA synthetase family. (581 aa) |
| | ADY14702.1 | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (299 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (156 aa) |
| | pgi | KEGG: ssm:Spirs_3245 phosphoglucose isomerase (PGI); HAMAP: Phosphoglucose isomerase (PGI); PFAM: Phosphoglucose isomerase (PGI); Belongs to the GPI family. (523 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (446 aa) |
| | ADY14731.1 | PFAM: Acyl-ACP thioesterase; KEGG: ssm:Spirs_4020 acyl-ACP thioesterase. (274 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (598 aa) |
| | ADY14756.1 | PFAM: Class II aldolase/adducin, N-terminal; KEGG: ssm:Spirs_2391 class II aldolase/adducin family protein. (221 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (588 aa) |
| | ADY14783.1 | KEGG: sfu:Sfum_3581 Asp/Glu racemase. (219 aa) |
| | ADY14803.1 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (276 aa) |
| | ADY14817.1 | PFAM: D-galactarate dehydratase/Altronate hydrolase, C-terminal; SAF domain; KEGG: ttm:Tthe_2395 altronate dehydratase; SMART: SAF domain. (508 aa) |
| | uxaC | HAMAP: Uronate isomerase; KEGG: cow:Calow_1181 glucuronate isomerase; PFAM: Uronate isomerase. (467 aa) |
| | ADY14851.1 | PFAM: Peptidase C26; KEGG: glutamine amidotransferase, class I. (242 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
