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| | ADY11880.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1171 aa) |
| | ADY11882.1 | TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; KEGG: ssm:Spirs_0275 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; Prephenate dehydratase; Amino acid-binding ACT. (636 aa) |
| | ADY11885.1 | KEGG: pmz:HMPREF0659_A5807 L-serine ammonia-lyase; PFAM: Serine dehydratase-like, alpha subunit; Serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (402 aa) |
| | ADY11896.1 | KEGG: gym:GYMC10_2999 Asp/Glu/hydantoin racemase. (222 aa) |
| | ADY11948.1 | KEGG: cce:Ccel_1104 hypothetical protein. (326 aa) |
| | ADY11953.1 | PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; KEGG: cth:Cthe_0202 L-glutamine synthetase. (426 aa) |
| | ADY11954.1 | PFAM: Glutamate synthase, alpha subunit, C-terminal; KEGG: cth:Cthe_0201 glutamate synthase (NADPH) GltB3 subunit. (241 aa) |
| | ADY11957.1 | KEGG: cth:Cthe_0198 glutamate synthase (NADPH) GltB2 subunit; PFAM: Glutamate synthase, central-C; 4Fe-4S binding domain. (501 aa) |
| | ADY11958.1 | PFAM: Glutamine amidotransferase, class-II; KEGG: cth:Cthe_0197 glutamate synthase (NADPH) GltB1 subunit. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | argD | PFAM: Aminotransferase class-III; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: elm:ELI_2182 hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (398 aa) |
| | ADY11969.1 | TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; KEGG: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (558 aa) |
| | ADY12004.1 | PFAM: Peptidase M20; Peptidase M20, dimerisation; KEGG: mta:Moth_0710 peptidase. (383 aa) |
| | ADY12020.1 | KEGG: pen:PSEEN1035 ornithine decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2, N-terminal; Orn/DAP/Arg decarboxylase 2, C-terminal; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (397 aa) |
| | ADY12022.1 | KEGG: ssm:Spirs_0510 dihydrodipicolinate synthetase; HAMAP: Dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (300 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (341 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (294 aa) |
| | ADY12198.1 | Riboflavin kinase; KEGG: ere:EUBREC_1939 bifunctional riboflavin kinase/FMN adenylyltransferase; PFAM: Riboflavin kinase; SMART: Riboflavin kinase. (230 aa) |
| | ADY12202.1 | Diaminopimelate decarboxylase; KEGG: elm:ELI_1799 putative pyridoxal-dependent decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2, N-terminal. (400 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa) |
| | ADY12255.1 | TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: dae:Dtox_4079 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal. (430 aa) |
| | ADY12273.1 | PFAM: Aminoglycoside phosphotransferase; KEGG: cpf:CPF_1410 MdsC protein. (360 aa) |
| | ADY12293.1 | PFAM: Class II aldolase/adducin, N-terminal; KEGG: mmw:Mmwyl1_2551 putative aldolase. (206 aa) |
| | fabV | Reductase; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA); Belongs to the TER reductase family. (403 aa) |
| | ADY12301.1 | PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ; KEGG: sta:STHERM_c08550 beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ. (145 aa) |
| | ADY12302.1 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (417 aa) |
| | ADY12304.1 | (Acyl-carrier-protein) S-malonyltransferase; KEGG: sta:STHERM_c21550 hypothetical protein; SMART: Polyketide synthase, acyl transferase domain. (313 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa) |
| | ADY12306.1 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (142 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (256 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (305 aa) |
| | ADY12312.1 | KEGG: cpb:Cphamn1_2546 hypothetical protein. (281 aa) |
| | ADY12407.1 | KEGG: dhd:Dhaf_2635 triosephosphate isomerase; PFAM: Triosephosphate isomerase. (286 aa) |
| | ADY12411.1 | PFAM: Phosphoglucose isomerase (PGI); KEGG: gmc:GY4MC1_3102 glucose-6-phosphate isomerase. (426 aa) |
| | ADY12477.1 | KEGG: cpe:CPE0924 metallo-beta-lactamase family protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (274 aa) |
| | ADY12485.1 | PFAM: Phosphoribosyltransferase; KEGG: ssm:Spirs_0876 phosphoribosyltransferase. (185 aa) |
| | ADY12486.1 | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: toc:Toce_2097 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (185 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa) |
| | hisC | PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: cpi:Cpin_1819 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | hisB | PFAM: Imidazoleglycerol-phosphate dehydratase; TIGRFAM: Histidinol-phosphatase; Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: chu:CHU_1270 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (375 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: fjo:Fjoh_2873 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis. (244 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | hisI | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: sli:Slin_5481 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like; Phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (202 aa) |
| | ADY12551.1 | Phosphoglycerate dehydrogenase; KEGG: cpy:Cphy_1465 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (326 aa) |
| | ADY12554.1 | KEGG: ssm:Spirs_0510 dihydrodipicolinate synthetase; HAMAP: Dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (300 aa) |
| | ADY12641.1 | KEGG: ssm:Spirs_3682 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (257 aa) |
| | ADY12664.1 | D-amino-acid transaminase; KEGG: ssm:Spirs_0479 aminotransferase class IV; PFAM: Aminotransferase, class IV. (270 aa) |
| | ADY12675.1 | KEGG: ssm:Spirs_0574 aspartate kinase; TIGRFAM: Aspartate kinase domain; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (435 aa) |
| | ADY12710.1 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (348 aa) |
| | ADY12712.1 | Adenosylcobinamide-phosphate guanylyltransferase; KEGG: cte:CT0945 cobalamin biosynthesis protein CobP; PFAM: Cobinamide kinase/cobinamide phosphate guanyltransferase. (215 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (248 aa) |
| | ADY12714.1 | KEGG: sta:STHERM_c21790 hypothetical protein; TIGRFAM: Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase-like hydrolase. (201 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (174 aa) |
| | ADY12778.1 | KEGG: ate:Athe_0503 acetolactate synthase small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (176 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (537 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (352 aa) |
| | ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: amt:Amet_3401 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (561 aa) |
| | ADY12786.1 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: cpy:Cphy_3347 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (560 aa) |
| | ADY12822.1 | TIGRFAM: Diaminopropionate ammonia-lyase; KEGG: ctc:CTC00071 diaminopropionate ammonia-lyase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (414 aa) |
| | ADY12849.1 | TIGRFAM: Branched-chain amino acid aminotransferase II; KEGG: eel:EUBELI_01912 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV. (341 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (404 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (287 aa) |
| | ADY12946.1 | TIGRFAM: Dihydrodipicolinate reductase, bacterial/plant; KEGG: sta:STHERM_c08680 dihydrodipicolinate reductase; PFAM: Dihydrodipicolinate reductase, C-terminal; Dihydrodipicolinate reductase, N-terminal; Belongs to the DapB family. (253 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (409 aa) |
| | ADY12949.1 | KEGG: ssm:Spirs_1460 Orn/DAP/Arg decarboxylase 2; PFAM: Orn/DAP/Arg decarboxylase 2, C-terminal; Orn/DAP/Arg decarboxylase 2, N-terminal. (421 aa) |
| | ADY12950.1 | KEGG: tol-pal system-associated acyl-CoA thioesterase; TIGRFAM: 4-hydroxybenzoyl-CoA thioesterase; PFAM: Thioesterase superfamily. (138 aa) |
| | ADY12979.1 | KEGG: cbe:Cbei_1932 iron-containing alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, iron-type. (399 aa) |
| | asnA | PFAM: Aspartate--ammonia ligase; TIGRFAM: Aspartate--ammonia ligase; HAMAP: Aspartate--ammonia ligase; KEGG: pdi:BDI_3717 asparagine synthetase AsnA. (344 aa) |
| | argG | PFAM: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: tma:TM1780 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | ADY13025.1 | PFAM: Haloacid dehalogenase-like hydrolase. (223 aa) |
| | ADY13040.1 | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (232 aa) |
| | aroE-2 | 3-dehydroquinate dehydratase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (494 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (349 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | ADY13059.1 | Protein of unknown function DUF165; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (231 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (177 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | thiI | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (399 aa) |
| | ADY13153.1 | KEGG: ssm:Spirs_1902 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase AroB. (379 aa) |
| | ADY13178.1 | KEGG: ssm:Spirs_1940 thiamine pyrophosphokinase; TIGRFAM: Thiamin pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic domain. (210 aa) |
| | ADY13180.1 | KEGG: tde:TDE1502 chorismate mutase; TIGRFAM: Chorismate mutase, AroH class; PFAM: Chorismate mutase, AroH class. (122 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (373 aa) |
| | ADY13217.1 | PFAM: FAD synthetase; KEGG: sta:STHERM_c11150 riboflavin biosynthesis protein RibF. (278 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (346 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | ADY13253.1 | KEGG: ssm:Spirs_2435 phosphoribosyl transferase domain protein. (206 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa) |
| | ADY13319.1 | KEGG: eel:EUBELI_00570 hypothetical protein. (196 aa) |
| | ADY13322.1 | KEGG: syn:sll0873 carboxynorspermidine decarboxylase; TIGRFAM: Carboxynorspermidine decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2, C-terminal. (371 aa) |
| | ADY13359.1 | S-methyl-5'-thioadenosine phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (257 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (357 aa) |
| | ADY13400.1 | PFAM: Protein of unknown function DUF161; KEGG: aco:Amico_1695 protein of unknown function DUF161. (219 aa) |
| | ADY13415.1 | Alcohol dehydrogenase zinc-binding domain protein; KEGG: esi:Exig_1460 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; SMART: Polyketide synthase, enoylreductase. (307 aa) |
| | ADY13429.1 | KEGG: sme:SM_b20299 N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase. (295 aa) |
| | ADY13436.1 | PFAM: UbiA prenyltransferase; KEGG: sta:STHERM_c19810 hypothetical protein. (304 aa) |
| | ADY13455.1 | 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: ipo:Ilyop_0077 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (322 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
| | ADY13467.1 | Phosphoglycerate dehydrogenase; KEGG: ssm:Spirs_2138 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (294 aa) |
| | ADY13479.1 | PFAM: Dihydrodipicolinate synthetase; TIGRFAM: Dihydrodipicolinate synthase subfamily; HAMAP: Dihydrodipicolinate synthase; KEGG: ant:Arnit_1025 dihydrodipicolinate synthase; Belongs to the DapA family. (298 aa) |
| | ADY13481.1 | Protein of unknown function DUF165; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (214 aa) |
| | ADY13535.1 | TIGRFAM: Threonine synthase; KEGG: threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (422 aa) |
| | ADY13536.1 | TIGRFAM: Aspartate kinase domain; KEGG: ssm:Spirs_2770 aspartate kinase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT. (798 aa) |
| | ADY13556.1 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: cpy:Cphy_0010 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (432 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa) |
| | ADY13558.1 | KEGG: transcriptional regulator, MarR family; PFAM: Nucleoside phosphorylase domain. (235 aa) |
| | ADY13559.1 | TIGRFAM: Initiation factor 2B alpha/beta/delta; KEGG: ssm:Spirs_3887 eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: Initiation factor 2B-related; Belongs to the eIF-2B alpha/beta/delta subunits family. (339 aa) |
| | ADY13570.1 | TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; KEGG: cce:Ccel_3186 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (309 aa) |
| | ADY13576.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa) |
| | ADY13578.1 | KEGG: gur:Gura_2063 beta-lactamase domain-containing protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (257 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (271 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (442 aa) |
| | ADY13636.1 | TIGRFAM: Probable carbamoyltransferase YgeW; KEGG: ssm:Spirs_1395 carbamoyltransferase YgeW; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (399 aa) |
| | ADY13640.1 | Putative selenium metabolism hydrolase; KEGG: ssm:Spirs_1388 M20/DapE family protein YgeY; TIGRFAM: putative selenium metabolism hydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (405 aa) |
| | ADY13643.1 | PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; KEGG: ssm:Spirs_1385 pyridoxal-5'-phosphate-dependent protein beta subunit. (489 aa) |
| | ADY13644.1 | Threonine synthase; KEGG: ssm:Spirs_1384 pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (407 aa) |
| | mtnA-2 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (345 aa) |
| | ADY13782.1 | ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR; KEGG: rrs:RoseRS_0557 cob(I)alamin adenosyltransferase. (178 aa) |
| | ADY13784.1 | 4-hydroxythreonine-4-phosphate dehydrogenase; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: fnu:FN0226 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; Belongs to the PdxA family. (342 aa) |
| | ADY13806.1 | KEGG: ssm:Spirs_1684 serine O-acetyltransferase. (308 aa) |
| | ADY13809.1 | Arogenate dehydrogenase (NADP(+)); Manually curated; KEGG: ssm:Spirs_1513 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (252 aa) |
| | ADY13834.1 | Hypothetical protein; KEGG: chu:CHU_0232 antifreeze-related protein. (560 aa) |
| | ADY13851.1 | TIGRFAM: Argininosuccinate lyase; KEGG: ssm:Spirs_3701 argininosuccinate lyase; PFAM: Lyase 1, N-terminal. (457 aa) |
| | ADY13865.1 | PFAM: Class II aldolase/adducin, N-terminal; KEGG: pjd:Pjdr2_1890 class II aldolase/adducin family protein. (358 aa) |
| | ADY13876.1 | PFAM: Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: tde:TDE0353 GDSL family lipase/acylhydrolase. (319 aa) |
| | ADY13892.1 | PFAM: Nucleoside phosphorylase domain; KEGG: sta:STHERM_c12670 MTA/SAH nucleosidase. (222 aa) |
| | ADY13893.1 | PfkB domain protein; PFAM: Carbohydrate/purine kinase; KEGG: dat:HRM2_15500 pyridoxamine kinase; Belongs to the pyridoxine kinase family. (274 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (394 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (509 aa) |
| | ADY13976.1 | KEGG: shi:Shel_01840 C_GCAxxG_C_C family probable redox protein; TIGRFAM: CGCAxxGCC motif; PFAM: CGCAxxGCC motif. (141 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa) |
| | ADY14008.1 | KEGG: gym:GYMC10_0510 dihydrodipicolinate synthetase; Belongs to the DapA family. (355 aa) |
| | ADY14010.1 | Amidohydrolase; KEGG: aar:Acear_1192 amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation; Belongs to the peptidase M20A family. (427 aa) |
| | ADY14033.1 | KEGG: sus:Acid_2860 aldehyde reductase; PFAM: NADP-dependent oxidoreductase domain. (336 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (125 aa) |
| | ADY14361.1 | KEGG: clj:CLJU_c30120 phosphoglycerate dehydrogenase-like protein; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (321 aa) |
| | ADY14382.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (338 aa) |
| | ADY14476.1 | PFAM: Asp/Glu/hydantoin racemase; KEGG: rlt:Rleg2_5297 hypothetical protein. (220 aa) |
| | ADY14478.1 | KEGG: 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (368 aa) |
| | ADY14502.1 | TIGRFAM: Alpha-acetolactate decarboxylase; KEGG: pth:PTH_2358 alpha-acetolactate decarboxylase; PFAM: Alpha-acetolactate decarboxylase. (302 aa) |
| | ADY14512.1 | PFAM: Dihydrodipicolinate synthetase; KEGG: gym:GYMC10_3581 dihydrodipicolinate synthetase; Belongs to the DapA family. (307 aa) |
| | ADY11878.1 | PFAM: Domain of unknown function DUF39; KEGG: tle:Tlet_1363 hypothetical protein. (386 aa) |
| | ADY14523.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa) |
| | ADY14534.1 | SMART: Semialdehyde dehydrogenase, NAD-binding; TIGRFAM: Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking; KEGG: ssm:Spirs_4027 aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD-binding; Semialdehyde dehydrogenase, dimerisation domain; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | ADY14555.1 | PFAM: Haloacid dehalogenase-like hydrolase. (245 aa) |
| | ADY14561.1 | KEGG: dtu:Dtur_0626 hypothetical protein. (240 aa) |
| | ADY14679.1 | Gly-Xaa carboxypeptidase; KEGG: mxa:MXAN_2289 hypothetical protein; PFAM: Peptidase M20; Peptidase M20, dimerisation. (477 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (156 aa) |
| | pgi | KEGG: ssm:Spirs_3245 phosphoglucose isomerase (PGI); HAMAP: Phosphoglucose isomerase (PGI); PFAM: Phosphoglucose isomerase (PGI); Belongs to the GPI family. (523 aa) |
| | ADY14731.1 | PFAM: Acyl-ACP thioesterase; KEGG: ssm:Spirs_4020 acyl-ACP thioesterase. (274 aa) |
| | ADY14749.1 | SMART: Methylglyoxal synthase-like domain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; KEGG: sta:STHERM_c07390 carbamoyl-phosphate synthase large chain; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; Methylglyoxal synthase-like domain; Belongs to the CarB family. (1069 aa) |
| | ADY14756.1 | PFAM: Class II aldolase/adducin, N-terminal; KEGG: ssm:Spirs_2391 class II aldolase/adducin family protein. (221 aa) |
| | ADY14783.1 | KEGG: sfu:Sfum_3581 Asp/Glu racemase. (219 aa) |
| | ADY14787.1 | 4-hydroxythreonine-4-phosphate dehydrogenase; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: dhd:Dhaf_1967 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; Belongs to the PdxA family. (335 aa) |
| | ADY14803.1 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (276 aa) |
