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| | ADY13242.1 | RNA modification enzyme, MiaB family; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (433 aa) |
| | ADY13237.1 | Integrase family protein; PFAM: Integrase, catalytic core, phage; KEGG: ssm:Spirs_2778 integrase family protein. (431 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (163 aa) |
| | ruvA | Holliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (210 aa) |
| | ruvB | Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (353 aa) |
| | ADY13224.1 | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. (865 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (497 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (120 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (297 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (702 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (373 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | recA | Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (361 aa) |
| | ADY13202.1 | TIGRFAM: Pseudouridine synthase, RsuA/RluB/E/F; PFAM: RNA-binding S4; Pseudouridine synthase, RsuA and RluB/C/D/E/F; KEGG: ssm:Spirs_2054 RNA-binding S4 domain protein; SMART: RNA-binding S4; Belongs to the pseudouridine synthase RsuA family. (250 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (685 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (598 aa) |
| | ADY13176.1 | PFAM: Sua5/YciO/YrdC, N-terminal; KEGG: ssm:Spirs_1938 SUA5/YciO/YrdC/YwlC family protein; Belongs to the SUA5 family. (189 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (307 aa) |
| | ADY13158.1 | PFAM: Transposase, IS204/IS1001/IS1096/IS1165; KEGG: mac:MA2406 transposase. (434 aa) |
| | ADY13156.1 | TIGRFAM: Poly(A) polymerase, PcnB; KEGG: ssm:Spirs_1905 poly(A) polymerase; PFAM: Poly A polymerase, head domain; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (422 aa) |
| | hisS | PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Anticodon-binding; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; KEGG: ssm:Spirs_1904 histidyl-tRNA synthetase. (444 aa) |
| | ADY13154.1 | KEGG: ssm:Spirs_1903 protein of unknown function DUF1605; PFAM: Domain of unknown function DUF1605; Helicase-associated domain; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; Helicase-associated domain. (830 aa) |
| | thiI | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (399 aa) |
| | ADY13142.1 | TIGRFAM: Tryptophanyl-tRNA synthetase, class Ib; KEGG: cpy:Cphy_3480 tryptophanyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ib. (330 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1042 aa) |
| | ADY13138.1 | TIGRFAM: Uncharacterised protein family HDIG; PFAM: Poly A polymerase, head domain; Metal-dependent phosphohydrolase, HD subdomain; KEGG: ssm:Spirs_1890 polynucleotide adenylyltransferase/metal dependent phosphohydrolase; SMART: Metal-dependent phosphohydrolase, HD domain. (452 aa) |
| | rnc | Ribonuclease 3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (248 aa) |
| | trmD | tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (250 aa) |
| | ADY13375.1 | KEGG: afl:Aflv_2632 IstB-like ATP-binding protein; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core. (260 aa) |
| | ADY13376.1 | PFAM: Integrase, catalytic core; KEGG: tte:TTE1156 integrase core subunit. (419 aa) |
| | ADY13380.1 | KEGG: str:Sterm_1842 hypothetical protein. (193 aa) |
| | ADY13399.1 | KEGG: sds:SDEG_1002 hypothetical protein. (225 aa) |
| | ADY13414.1 | Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: sti:Sthe_2590 metallophosphoesterase. (404 aa) |
| | ADY13423.1 | KEGG: mif:Metin_0755 SUA5/YciO/YrdC/YwlC family protein; TIGRFAM: Sua5/YciO/YrdC/YwlC; PFAM: Sua5/YciO/YrdC, N-terminal; SUA5; Belongs to the SUA5 family. (437 aa) |
| | ADY13458.1 | PP-loop domain protein; PFAM: tRNA(Ile)-lysidine/2-thiocytidine synthase; KEGG: ssm:Spirs_2353 PP-loop domain protein; Belongs to the TtcA family. (249 aa) |
| | mutL | DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (588 aa) |
| | ADY13469.1 | KEGG: ssm:Spirs_2141 single-stranded-DNA-specific exonuclease RecJ; TIGRFAM: Bacterial RecJ exonuclease; PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1. (709 aa) |
| | recO | DNA repair protein recO; Involved in DNA repair and RecF pathway recombination. (251 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (882 aa) |
| | ADY13490.1 | KEGG: ssm:Spirs_2153 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70; PFAM: RNA polymerase sigma factor 70, region 4 type 2; RNA polymerase sigma-70 region 2. (172 aa) |
| | cysS | TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; KEGG: sta:STHERM_c18260 hypothetical protein; PFAM: Cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (471 aa) |
| | ADY13527.1 | TIGRFAM: DNA helicase, ATP-dependent, RecQ type; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; KEGG: ssm:Spirs_2762 ATP-dependent DNA helicase, RecQ family; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal. (506 aa) |
| | ADY13532.1 | PFAM: Transposase, IS204/IS1001/IS1096/IS1165; KEGG: mac:MA2406 transposase. (434 aa) |
| | nth | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (214 aa) |
| | ADY13560.1 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: ipo:Ilyop_0137 CMP/dCMP deaminase zinc-binding protein. (169 aa) |
| | ADY13567.1 | DNA-(apurinic or apyrimidinic site) lyase; PFAM: 8-oxoguanine DNA glycosylase, N-terminal; HhH-GPD domain; KEGG: cob:COB47_1460 8-oxoguanine DNA glycosylase domain-containing protein; SMART: HhH-GPD domain. (253 aa) |
| | asnS | PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; TIGRFAM: Asparaginyl-tRNA synthetase, class IIb; HAMAP: Asparaginyl-tRNA synthetase, class IIb; KEGG: ssm:Spirs_2248 asparaginyl-tRNA synthetase. (462 aa) |
| | ADY13598.1 | Protein of unknown function UPF0044; PFAM: RNA-binding, CRM domain; KEGG: mgm:Mmc1_3700 hypothetical protein. (101 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (319 aa) |
| | ADY13605.1 | Hypothetical protein. (67 aa) |
| | ADY13608.1 | KEGG: ssm:Spirs_2281 YicC domain protein; TIGRFAM: Conserved hypothetical protein CHP00255; PFAM: Domain of unknown function DUF1732; YicC-like, N-terminal. (289 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (400 aa) |
| | ADY13618.1 | tRNA/rRNA methyltransferase (SpoU); Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (166 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa) |
| | ADY13350.1 | TIGRFAM: DNA polymerase III, alpha subunit; KEGG: dol:Dole_0237 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; Nucleic acid binding, OB-fold, tRNA/helicase-type. (970 aa) |
| | ADY13646.1 | Integrase family protein; PFAM: Integrase, catalytic core, phage; KEGG: abm:ABSDF1381 putative phage integrase; Belongs to the 'phage' integrase family. (432 aa) |
| | ADY13655.1 | PFAM: Bacteriophage lambda NinG; KEGG: pdi:BDI_0857 putative recombination protein. (151 aa) |
| | ADY13658.1 | KEGG: sta:STHERM_c13180 single-strand binding protein; TIGRFAM: Single-strand DNA-binding; PFAM: Primosome PriB/single-strand DNA-binding. (134 aa) |
| | ADY13660.1 | ERF family protein; PFAM: ERF; KEGG: cpy:Cphy_2988 hypothetical protein. (287 aa) |
| | ADY13693.1 | KEGG: she:Shewmr4_3737 hypothetical protein. (289 aa) |
| | ADY13712.1 | PFAM: Deoxyribonuclease, TatD-related; KEGG: sta:STHERM_c07890 hypothetical protein. (259 aa) |
| | ADY13720.1 | KEGG: tde:TDE1469 hypothetical protein; TIGRFAM: Uncharacterised protein family UPF0079, ATPase bacteria; PFAM: Uncharacterised protein family UPF0079, ATPase bacteria. (139 aa) |
| | ADY13721.1 | Universal protein YeaZ; KEGG: ssm:Spirs_2605 peptidase M22 glycoprotease; TIGRFAM: Conserved hypothetical protein CHP03725, YeaZ; PFAM: Peptidase M22, glycoprotease. (233 aa) |
| | uvrB | UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (689 aa) |
| | glnS | PFAM: Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain; Glutamyl/glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain; TIGRFAM: Glutaminyl-tRNA synthetase, class Ic; HAMAP: Glutaminyl-tRNA synthetase, bacterial; KEGG: ssm:Spirs_1481 glutaminyl-tRNA synthetase. (562 aa) |
| | ADY13747.1 | rRNA (guanine-N(2)-)-methyltransferase; KEGG: ske:Sked_22180 hypothetical protein. (879 aa) |
| | tilS | tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (484 aa) |
| | ADY13763.1 | PFAM: Uracil-DNA glycosylase-like; KEGG: ssm:Spirs_3799 uracil-DNA glycosylase superfamily. (256 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (418 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (443 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (494 aa) |
| | ADY13776.1 | PFAM: Metal-dependent phosphohydrolase, HD subdomain; KEGG: elm:ELI_1524 hypothetical protein. (237 aa) |
| | ADY13780.1 | KEGG: cyh:Cyan8802_0995 RloA protein. (415 aa) |
| | rimM | Ribosome maturation factor rimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (168 aa) |
| | argS | KEGG: ssm:Spirs_1801 arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic; HAMAP: Arginyl-tRNA synthetase, class Ic. (587 aa) |
| | ADY13808.1 | TIGRFAM: MiaB-like tRNA modifying enzyme; Methylthiotransferase; PFAM: Methylthiotransferase, N-terminal; Radical SAM; KEGG: ssm:Spirs_1516 MiaB-like tRNA modifying enzyme; SMART: Elongator protein 3/MiaB/NifB. (437 aa) |
| | rsmA | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (292 aa) |
| | ADY13817.1 | Manually curated; KEGG: phe:Phep_4225 PUA domain containing protein. (408 aa) |
| | ADY13835.1 | KEGG: ssm:Spirs_3308 YbaK/EbsC protein; TIGRFAM: Prolyl-tRNA editing protein, YbaK/EbsC; PFAM: YbaK/aminoacyl-tRNA synthetase-associated domain. (155 aa) |
| | ADY13845.1 | KEGG: dtu:Dtur_1798 radical SAM domain protein. (388 aa) |
| | ADY13856.1 | KEGG: ssm:Spirs_3718 single-strand binding protein; TIGRFAM: Single-strand DNA-binding; PFAM: Primosome PriB/single-strand DNA-binding. (132 aa) |
| | ADY13858.1 | PFAM: Metal-dependent phosphohydrolase, HD subdomain; KEGG: tko:TK0480 HD superfamily metal-dependent phosphohydrolase. (420 aa) |
| | ADY13895.1 | DNA mismatch endonuclease Vsr; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. (142 aa) |
| | ADY13898.1 | PFAM: Exonuclease C-terminal; Exonuclease, RNase T/DNA polymerase III; KEGG: slo:Shew_1611 exonuclease I; SMART: Exonuclease. (471 aa) |
| | ADY13919.1 | KEGG: ssm:Spirs_0462 Smr protein/MutS2; PFAM: Smr protein/MutS2 C-terminal; SMART: Smr protein/MutS2 C-terminal. (328 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (847 aa) |
| | ADY13939.1 | Radical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. (361 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (598 aa) |
| | ADY13944.1 | KEGG: toc:Toce_0259 HhH-GPD family protein; PFAM: HhH-GPD domain; SMART: HhH-GPD domain. (199 aa) |
| | ADY13958.1 | KEGG: hypothetical protein. (368 aa) |
| | cas2 | CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (108 aa) |
| | cas1 | CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (300 aa) |
| | cas9 | CRISPR-associated protein, Csn1 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this [...] (1179 aa) |
| | rimO | Ribosomal protein S12 methylthiotransferase rimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (449 aa) |
| | ADY14042.1 | KEGG: chd:Calhy_1972 hypothetical protein. (438 aa) |
| | ADY14060.1 | PFAM: DNA helicase, UvrD/REP type; KEGG: ssm:Spirs_3944 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1104 aa) |
| | ADY14061.1 | KEGG: ssm:Spirs_3945 hypothetical protein. (871 aa) |
| | ADY14078.1 | KEGG: cts:Ctha_1807 DNA/RNA non-specific endonuclease; PFAM: DNA/RNA non-specific endonuclease; SMART: DNA/RNA non-specific endonuclease; Extracellular Endonuclease, subunit A. (351 aa) |
| | ADY14095.1 | KEGG: cyb:CYB_2566 hypothetical protein. (574 aa) |
| | ADY14104.1 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (314 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (654 aa) |
| | ADY14108.1 | KEGG: sta:STHERM_c18320 hypothetical protein; TIGRFAM: Phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase-like. (249 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (281 aa) |
| | nfo | Endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (280 aa) |
| | ADY14127.1 | PFAM: Transposase, IS4-like; KEGG: cli:Clim_2142 transposase IS4 family protein. (534 aa) |
| | ADY14137.1 | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: ssm:Spirs_3694 endonuclease/exonuclease/phosphatase. (331 aa) |
| | ADY14140.1 | KEGG: eel:EUBELI_20456 hypothetical protein. (475 aa) |
| | lysS | PFAM: Lysyl-tRNA synthetase, class Ic; TIGRFAM: Lysyl-tRNA synthetase, class I; HAMAP: Lysyl-tRNA synthetase, class I, archaeal-type; KEGG: ssm:Spirs_3699 lysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (524 aa) |
| | ADY14147.1 | Integrase domain protein SAM domain protein; PFAM: Integrase, N-terminal SAM-like, phage; Integrase, catalytic core, phage; KEGG: ssm:Spirs_1738 hypothetical protein; Belongs to the 'phage' integrase family. (422 aa) |
| | ADY14157.1 | KEGG: cth:Cthe_2466 hypothetical protein. (251 aa) |
| | ADY14158.1 | DnaB domain protein helicase domain protein; PFAM: DNA helicase, DnaB-like, C-terminal; KEGG: sta:STHERM_c13140 hypothetical protein. (415 aa) |
| | ADY14161.1 | KEGG: sta:STHERM_c13180 single-strand binding protein; TIGRFAM: Single-strand DNA-binding; PFAM: Primosome PriB/single-strand DNA-binding. (125 aa) |
| | ADY14163.1 | ERF family protein; PFAM: ERF; KEGG: cpy:Cphy_2988 hypothetical protein. (277 aa) |
| | ADY14168.1 | PFAM: Integrase, catalytic core; KEGG: bha:BH3965 transposase (22). (545 aa) |
| | ADY14169.1 | KEGG: amt:Amet_4685 IstB ATP binding domain-containing protein; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core. (254 aa) |
| | ADY14185.1 | Hypothetical protein; KEGG: aai:AARI_36250 transposase of ISAar33, IS21 family, IstA. (107 aa) |
| | ADY14187.1 | Hypothetical protein; KEGG: amc:MADE_00823 phage uncharacterized protein. (377 aa) |
| | ADY14189.1 | PFAM: DNA methylase N-4/N-6; KEGG: sfu:Sfum_2856 DNA methylase N-4/N-6 domain-containing protein. (932 aa) |
| | ADY14190.1 | PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; KEGG: dau:Daud_0199 type III restriction enzyme, res subunit. (1016 aa) |
| | ADY14191.1 | KEGG: shi:Shel_27120 hypothetical protein. (342 aa) |
| | ADY14197.1 | KEGG: shi:Shel_27120 hypothetical protein. (335 aa) |
| | ADY14198.1 | KEGG: afl:Aflv_2632 IstB-like ATP-binding protein; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core. (260 aa) |
| | ADY14199.1 | PFAM: Integrase, catalytic core; KEGG: tte:TTE1156 integrase core subunit. (428 aa) |
| | ADY14204.1 | Transposase IS200-family protein; PFAM: Transposase IS200-like; KEGG: lsl:LSL_0050 IS200 family transposase. (139 aa) |
| | ADY14210.1 | PFAM: RNA polymerase, alpha subunit, C-terminal; KEGG: fma:FMG_0966 hypothetical protein. (395 aa) |
| | ADY14212.1 | KEGG: app:CAP2UW1_4401 hypothetical protein. (297 aa) |
| | ADY14215.1 | Hypothetical protein. (78 aa) |
| | ADY14228.1 | PFAM: Transposase, IS4-like; KEGG: cli:Clim_2142 transposase IS4 family protein. (552 aa) |
| | ADY14252.1 | KEGG: sga:GALLO_1564 hypothetical protein; TIGRFAM: Addiction module toxin, RelE/StbE; PFAM: Plasmid stabilisation system. (91 aa) |
| | ADY14266.1 | PFAM: Integrase, catalytic core; KEGG: ajs:Ajs_3050 integrase catalytic subunit. (520 aa) |
| | ADY14276.1 | KEGG: shi:Shel_27120 hypothetical protein. (335 aa) |
| | ADY14383.1 | KEGG: ant:Arnit_1984 RNP-1 like RNA-binding protein; PFAM: RNA recognition motif domain; SMART: RNA recognition motif domain. (95 aa) |
| | ADY14422.1 | KEGG: ote:Oter_2247 restriction endonuclease. (302 aa) |
| | ADY14425.1 | PFAM: DNA mismatch repair MutH/Restriction endonuclease, type II, EcoRV-like; KEGG: tdn:Suden_1854 DNA mismatch repair enzyme MutH; SMART: DNA mismatch repair MutH/Restriction endonuclease, type II, EcoRV-like. (460 aa) |
| | ADY14429.1 | TIGRFAM: C-5 cytosine methyltransferase; KEGG: cpf:CPF_1017 DNA-cytosine methyltransferase; PFAM: C-5 cytosine methyltransferase. (402 aa) |
| | ADY14430.1 | Hypothetical protein; KEGG: hnh endonuclease. (243 aa) |
| | ADY14457.1 | KEGG: pvi:Cvib_0082 HNH endonuclease; PFAM: HNH endonuclease; SMART: HNH nuclease. (291 aa) |
| | ADY14466.1 | KEGG: shi:Shel_27120 hypothetical protein. (342 aa) |
| | ADY14472.1 | PFAM: Transposase, IS204/IS1001/IS1096/IS1165; KEGG: mac:MA2406 transposase. (434 aa) |
| | ADY14518.1 | PFAM: Protein of unknown function DUF1538; KEGG: dhd:Dhaf_1143 protein of unknown function DUF1538. (621 aa) |
| | ADY14524.1 | KEGG: ssm:Spirs_1372 3'-5' exonuclease; PFAM: 3'-5' exonuclease; SMART: 3'-5' exonuclease. (294 aa) |
| | ADY14536.1 | PFAM: Protein of unknown function DUF1538; KEGG: aoe:Clos_0656 hypothetical protein. (488 aa) |
| | ADY14554.1 | PHP domain protein; KEGG: cpy:Cphy_3026 phosphotransferase domain-containing protein; PFAM: PHP, C-terminal; SMART: Polymerase/histidinol phosphatase, N-terminal. (306 aa) |
| | ADY14563.1 | PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; KEGG: gau:GAU_3690 ribosomal large subunit pseudouridine synthase A. (417 aa) |
| | ADY14564.1 | PFAM: Domain of unknown function DUF88; KEGG: vpa:VP1078 hypothetical protein. (266 aa) |
| | ADY14570.1 | KEGG: ssm:Spirs_3729 hypothetical protein. (414 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (645 aa) |
| | ADY14610.1 | KEGG: ssm:Spirs_3191 hydrolase, TatD family; TIGRFAM: Deoxyribonuclease, TatD Mg-dependent, prokaryote; PFAM: Deoxyribonuclease, TatD-related. (261 aa) |
| | ADY14611.1 | TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (332 aa) |
| | ADY14620.1 | KEGG: ssm:Spirs_3194 RNA methyltransferase, TrmH family, group 3; TIGRFAM: RNA methyltransferase TrmH, group 3; PFAM: tRNA/rRNA methyltransferase, SpoU; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (251 aa) |
| | dnaJ | Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (379 aa) |
| | rny | 2,3 cyclic-nucleotide 2-phosphodiesterase; Endoribonuclease that initiates mRNA decay. (510 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (350 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1426 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1172 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (186 aa) |
| | ADY14683.1 | KEGG: shi:Shel_27120 hypothetical protein. (335 aa) |
| | thrS | TIGRFAM: Threonyl-tRNA synthetase, class IIa; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain; Threonyl/alanyl tRNA synthetase, SAD; Anticodon-binding; KEGG: ssm:Spirs_3229 threonyl-tRNA synthetase; SMART: Threonyl/alanyl tRNA synthetase, SAD; Belongs to the class-II aminoacyl-tRNA synthetase family. (581 aa) |
| | ADY14709.1 | KEGG: ssm:Spirs_2330 RNP-1 like RNA-binding protein; PFAM: RNA recognition motif domain; SMART: RNA recognition motif domain. (92 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (696 aa) |
| | ADY14727.1 | DNA polymerase III, alpha subunit; SMART: Polymerase/histidinol phosphatase, N-terminal; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: ssm:Spirs_1327 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type. (1155 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (695 aa) |
| | ADY14730.1 | Methyltransferase; KEGG: ssm:Spirs_1324 methyltransferase; TIGRFAM: RNA methyltransferase, RsmD; PFAM: RNA methyltransferase, RsmD. (186 aa) |
| | ADY14735.1 | KEGG: sta:STHERM_c21440 hypothetical protein; TIGRFAM: NGG1p interacting factor 3, NIF3; PFAM: NGG1p interacting factor 3, NIF3. (252 aa) |
| | ADY14738.1 | PFAM: tRNA/rRNA methyltransferase, SpoU; KEGG: ssm:Spirs_0318 tRNA/rRNA methyltransferase (SpoU). (266 aa) |
| | rsmI | Ribosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (237 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (598 aa) |
| | proS | Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (588 aa) |
| | rlmE | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (208 aa) |
| | ADY14834.1 | PFAM: Thymidine kinase; KEGG: ssm:Spirs_0100 thymidine kinase; Belongs to the thymidine kinase family. (380 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (543 aa) |
| | recR | Recombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (196 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (450 aa) |
| | gyrA | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (855 aa) |
| | gyrB | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (677 aa) |
| | ADY12981.1 | Beta-lactamase domain protein; KEGG: ere:EUBREC_2244 putative exonuclease of the beta-lactamase fold involved in RNA processing; PFAM: Beta-lactamase-like; RNA-metabolising metallo-beta-lactamase; SMART: Beta-lactamase-like. (559 aa) |
| | ADY12954.1 | PFAM: Deoxyribonuclease, TatD-related. (223 aa) |
| | ADY12953.1 | PFAM: UBA/THIF-type NAD/FAD binding fold; KEGG: dps:DP0137 hypothetical protein. (265 aa) |
| | ADY12934.1 | SMART: DNA topoisomerase, type IA, DNA-binding; DNA topoisomerase, type IA, domain 2; Toprim domain; TIGRFAM: DNA topoisomerase III, bacterial-type; KEGG: cce:Ccel_0922 DNA topoisomerase III; PFAM: DNA topoisomerase, type IA, central; Toprim domain. (774 aa) |
| | xseA | Exodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (398 aa) |
| | xseB | Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (69 aa) |
| | ADY12922.1 | PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; KEGG: tde:TDE1083 RNA pseudouridylate synthase. (245 aa) |
| | ADY12915.1 | KEGG: ssm:Spirs_1297 AAA ATPase central domain protein; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core. (727 aa) |
| | ADY12905.1 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: sta:STHERM_c05780 DHH superfamily protein, subfamily 1. (328 aa) |
| | ADY12870.1 | KEGG: ssm:Spirs_2330 RNP-1 like RNA-binding protein; PFAM: RNA recognition motif domain; SMART: RNA recognition motif domain. (90 aa) |
| | ADY12858.1 | KEGG: tcx:Tcr_1313 hypothetical protein. (167 aa) |
| | ADY12842.1 | KEGG: shi:Shel_27120 hypothetical protein. (335 aa) |
| | ADY12819.1 | PFAM: Domain of unknown function DUF1508; KEGG: elm:ELI_4348 protein YegP. (128 aa) |
| | ADY12800.1 | RNA-directed DNA polymerase (Reverse transcriptase); PFAM: Reverse transcriptase; Group II intron, maturase-specific; KEGG: lcz:LCAZH_2204 RNA-directed DNA polymerase. (472 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (174 aa) |
| | ADY12708.1 | KEGG: mpl:Mpal_2170 HhH-GPD family protein; PFAM: HhH-GPD domain; SMART: HhH-GPD domain. (294 aa) |
| | ADY12706.1 | PFAM: tRNA/rRNA methyltransferase, SpoU; KEGG: ssm:Spirs_2304 RNA methyltransferase, TrmH family, group 1. (247 aa) |
| | mnmA | tRNA-specific 2-thiouridylase mnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (356 aa) |
| | ADY12700.1 | KEGG: vpr:Vpar_0406 exonuclease RNase T and DNA polymerase III; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease. (197 aa) |
| | ADY12681.1 | KEGG: shi:Shel_27120 hypothetical protein. (335 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | rsmG | Ribosomal RNA small subunit methyltransferase G; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (219 aa) |
| | mnmG | tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (603 aa) |
| | mnmE | tRNA modification GTPase mnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (442 aa) |
| | ADY12659.1 | Lysine--tRNA ligase; KEGG: ssm:Spirs_3665 tRNA synthetase class II (D K and N); PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Belongs to the class-II aminoacyl-tRNA synthetase family. (330 aa) |
| | ADY12650.1 | KEGG: dat:HRM2_20220 hypothetical protein. (419 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (948 aa) |
| | ADY12636.1 | PFAM: (Uracil-5)-methyltransferase; KEGG: tde:TDE2619 RNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (383 aa) |
| | rlmL | rRNA (guanine-N(2)-)-methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (743 aa) |
| | ADY12609.1 | KEGG: ssm:Spirs_4048 RNA polymerase, sigma 54 subunit, RpoN; TIGRFAM: RNA polymerase sigma factor 54; PFAM: RNA polymerase sigma factor 54, DNA-binding; RNA polymerase sigma factor 54, core-binding; RNA polymerase sigma factor 54. (467 aa) |
| | ADY12605.1 | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response). (206 aa) |
| | ADY12604.1 | KEGG: ssm:Spirs_4056 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta. (343 aa) |
| | uvrC | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (617 aa) |
| | ADY12602.1 | KEGG: nis:NIS_0569 hypothetical protein. (416 aa) |
| | ADY12599.1 | Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (239 aa) |
| | smc | SMC domain protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (949 aa) |
| | rnhB | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (209 aa) |
| | tsaD | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (339 aa) |
| | ADY13111.1 | Putative RNA polymerase, sigma 70 family subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (293 aa) |
| | ADY13105.1 | Hypothetical protein; KEGG: ssm:Spirs_1707 DNA polymerase III gamma/tau subunits. (393 aa) |
| | ADY13096.1 | KEGG: gur:Gura_4012 tyrosine recombinase XerC; HAMAP: Tyrosine recombinase xerC; PFAM: Integrase, catalytic core, phage; Integrase, N-terminal SAM-like, phage; Belongs to the 'phage' integrase family. (297 aa) |
| | ADY13093.1 | KEGG: ssm:Spirs_1553 tyrosine recombinase XerD; HAMAP: Tyrosine recombinase xerC; PFAM: Integrase, catalytic core, phage; Integrase, N-terminal SAM-like, phage; Belongs to the 'phage' integrase family. (300 aa) |
| | rsmH | Ribosomal RNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (296 aa) |
| | ADY13082.1 | KEGG: sta:STHERM_c08890 hypothetical protein. (243 aa) |
| | ADY13078.1 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (557 aa) |
| | trmB | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (245 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1090 aa) |
| | ADY13036.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (461 aa) |
| | ADY13032.1 | KEGG: ssm:Spirs_2878 single-strand binding protein; TIGRFAM: Single-strand DNA-binding; PFAM: Primosome PriB/single-strand DNA-binding. (162 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (741 aa) |
| | ADY13021.1 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: cbf:CLI_1373 guanine deaminase. (156 aa) |
| | ADY13006.1 | PFAM: Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p; KEGG: ssm:Spirs_2381 Fmu (Sun) domain protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (262 aa) |
| | ADY12992.1 | TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; KEGG: fnu:FN0047 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase. (250 aa) |
| | ADY12567.1 | KEGG: dhd:Dhaf_4686 methylated-DNA/protein-cysteine methyltransferase; TIGRFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding. (99 aa) |
| | vapC | PilT protein domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (130 aa) |
| | ADY12490.1 | SMART: tRNA synthetase, B5; B3/B4 tRNA-binding domain; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic; KEGG: sta:STHERM_c21760 phenylalanyl-tRNA synthetase subunit beta; PFAM: tRNA synthetase, B5. (565 aa) |
| | pheS | TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain 2, bacterial/archaeal; KEGG: ssm:Spirs_4136 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (512 aa) |
| | ADY12467.1 | KEGG: ssm:Spirs_0879 alanyl-tRNA synthetase, class IIc; PFAM: Alanyl-tRNA synthetase, class IIc, N-terminal; Threonyl/alanyl tRNA synthetase, SAD; SMART: Threonyl/alanyl tRNA synthetase, SAD. (394 aa) |
| | ADY12448.1 | PFAM: Transposase, IS4-like; KEGG: eba:ebA573 IS4 family transposase. (370 aa) |
| | ADY12439.1 | Protein of unknown function DUF132; KEGG: tte:TTE2037 nucleic acid-binding protein; TIGRFAM: Protein of unknown function DUF132; SMART: Nucleotide binding protein, PINc. (133 aa) |
| | ADY12299.1 | PHP domain protein; PFAM: PHP, C-terminal; KEGG: bpb:bpr_I0127 PHP domain-containing protein. (260 aa) |
| | ADY12284.1 | KEGG: afn:Acfer_0736 abortive infection protein, putative. (436 aa) |
| | ADY12280.1 | KEGG: shi:Shel_27120 hypothetical protein. (342 aa) |
| | ADY12210.1 | KEGG: shi:Shel_27120 hypothetical protein. (335 aa) |
| | ADY12160.1 | Transporter; KEGG: fnu:FN1553 transporter. (468 aa) |
| | ADY12144.1 | Resolvase domain; KEGG: dsy:DSY3281 hypothetical protein; PFAM: Resolvase, N-terminal; Recombinase; SMART: Resolvase, N-terminal. (805 aa) |
| | ADY12142.1 | KEGG: dsy:DSY3282 hypothetical protein. (260 aa) |
| | ADY12136.1 | KEGG: csh:Closa_2762 resolvase domain protein; PFAM: Resolvase, N-terminal; Recombinase; SMART: Resolvase, N-terminal. (413 aa) |
| | ADY12135.1 | KEGG: dae:Dtox_1526 resolvase domain protein; PFAM: Resolvase, N-terminal; Recombinase; SMART: Resolvase, N-terminal. (545 aa) |
| | ADY12134.1 | KEGG: bse:Bsel_2989 resolvase domain-containing protein; PFAM: Resolvase, N-terminal; Recombinase; SMART: Resolvase, N-terminal. (318 aa) |
| | ADY12124.1 | PFAM: Protein of unknown function DUF927; KEGG: ccb:Clocel_0839 bifunctional DNA primase/polymerase. (997 aa) |
| | ADY12114.1 | PFAM: Integrase, catalytic core; KEGG: integrase catalytic region. (413 aa) |
| | ADY12113.1 | KEGG: kol:Kole_1506 IstB domain protein ATP-binding protein. (270 aa) |
| | ADY12100.1 | PFAM: Transposase, IS204/IS1001/IS1096/IS1165; KEGG: mac:MA2406 transposase. (434 aa) |
| | ADY12079.1 | KEGG: shi:Shel_27120 hypothetical protein. (359 aa) |
| | ADY12078.1 | KEGG: alv:Alvin_0247 SMC domain-containing protein. (388 aa) |
| | ADY12070.1 | KEGG: lfe:LAF_0101 hypothetical protein. (383 aa) |
| | ADY12067.1 | PFAM: Transcription antitermination protein, NusG, N-terminal; KEGG: rma:Rmag_0816 transcription antitermination protein NusG. (182 aa) |
| | ADY12059.1 | KEGG: aco:Amico_0150 SirA family protein; Belongs to the sulfur carrier protein TusA family. (69 aa) |
| | ADY12046.1 | KEGG: adg:Adeg_1768 hypothetical protein. (131 aa) |
| | ADY11980.1 | KEGG: csh:Closa_2855 RNA methyltransferase, TrmA family; TIGRFAM: 23S rRNA methyltransferase/RumA; PFAM: (Uracil-5)-methyltransferase; DNA methylase N-4/N-6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (390 aa) |
| | ADY11907.1 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (836 aa) |
| | ADY11895.1 | PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; KEGG: bvu:BVU_0383 ribosomal large subunit pseudouridine synthase D. (229 aa) |
| | ADY11894.1 | PFAM: DNA topoisomerase, type IIA, subunit A/C-terminal; KEGG: ssm:Spirs_4003 DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase, type IIA, subunit A/C-terminal. (659 aa) |
| | ADY11893.1 | KEGG: tde:TDE2245 DNA topoisomerase IV subunit B; PFAM: DNA topoisomerase, type IIA, subunit B, domain 2; ATPase-like, ATP-binding domain; SMART: DNA topoisomerase, type IIA, subunit B/N-terminal; ATPase-like, ATP-binding domain. (600 aa) |
| | leuS | TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial; KEGG: ssm:Spirs_0283 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (842 aa) |
| | ADY11881.1 | DNA-(apurinic or apyrimidinic site) lyase; PFAM: HhH-GPD domain; KEGG: sat:SYN_00287 endonuclease III N; SMART: HhH-GPD domain. (220 aa) |
| | ADY11867.1 | Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (263 aa) |
| | ADY11855.1 | KEGG: cth:Cthe_0646 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; PFAM: ATP-cone. (691 aa) |
| | rnpA | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (116 aa) |
| | recF | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (360 aa) |
| | ADY11848.1 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (368 aa) |
| | dnaA | Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (473 aa) |
| | ADY13349.1 | DNA-directed DNA polymerase; KEGG: pca:Pcar_1740 nucleotidyltransferase/DNA polymerase; PFAM: DNA-repair protein, UmuC-like. (392 aa) |
| | ADY13314.1 | KEGG: ATP-binding region ATPase domain-containing protein. (495 aa) |
| | ADY13313.1 | PFAM: Putative endonuclease, Z1 domain; KEGG: aba:Acid345_4267 endonuclease. (932 aa) |
| | ADY13311.1 | PFAM: Abortive phage infection; KEGG: aba:Acid345_4269 hypothetical protein. (715 aa) |
| | ADY13310.1 | KEGG: DNA-cytosine methyltransferase; TIGRFAM: C-5 cytosine methyltransferase; PFAM: C-5 cytosine methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (516 aa) |
| | rnhA | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (149 aa) |
| | ADY13287.1 | Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (333 aa) |
| | mutS2 | DNA mismatch repair protein MutS domain protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (782 aa) |
| | ADY13270.1 | methylated-DNA/protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (160 aa) |
| | uvrA | UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (944 aa) |
| | ybeY | Metalloprotease ybeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (182 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (152 aa) |
