STRINGSTRING
AEV27901.1 AEV27901.1 AEV27902.1 AEV27902.1 ackA ackA AEV27990.1 AEV27990.1 serC serC AEV27992.1 AEV27992.1 AEV28394.1 AEV28394.1 AEV28516.1 AEV28516.1 AEV28518.1 AEV28518.1 AEV28519.1 AEV28519.1 purU purU AEV28661.1 AEV28661.1 AEV28662.1 AEV28662.1 AEV28663.1 AEV28663.1 AEV28751.1 AEV28751.1 AEV28793.1 AEV28793.1 AEV28851.1 AEV28851.1 AEV28857.1 AEV28857.1 ilvD ilvD leuB leuB leuD leuD leuC leuC AEV28862.1 AEV28862.1 leuA leuA ilvC ilvC AEV28865.1 AEV28865.1 AEV28956.1 AEV28956.1 AEV28995.1 AEV28995.1 AEV29176.1 AEV29176.1 oadG oadG AEV29205.1 AEV29205.1 AEV29206.1 AEV29206.1 AEV29279.1 AEV29279.1 accA accA accD accD AEV29297.1 AEV29297.1 AEV29298.1 AEV29298.1 AEV29349.1 AEV29349.1 AEV29509.1 AEV29509.1 AEV29556.1 AEV29556.1 AEV29651.1 AEV29651.1 pckG pckG AEV30019.1 AEV30019.1 pckG-2 pckG-2 AEV30273.1 AEV30273.1 AEV30274.1 AEV30274.1 eno eno AEV30716.1 AEV30716.1 AEV30890.1 AEV30890.1 AEV30955.1 AEV30955.1 AEV30956.1 AEV30956.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEV27901.1PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase. (798 aa)
AEV27902.1Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (423 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (445 aa)
AEV27990.1Phosphoglycerate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (294 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa)
AEV27992.1Transcriptional regulator; PFAM: HTH domain; AsnC family. (151 aa)
AEV28394.1Pyruvate, phosphate dikinase; PFAM: PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate phosphate dikinase, PEP/pyruvate binding domain; TIGRFAM: pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (902 aa)
AEV28516.1PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family. (431 aa)
AEV28518.1PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (409 aa)
AEV28519.1Aconitate hydratase, putative, Aquifex type; PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase, putative, Aquifex type. (645 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (290 aa)
AEV28661.1PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. (241 aa)
AEV28662.1Formate acetyltransferase 1; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: formate acetyltransferase 1. (740 aa)
AEV28663.1Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (255 aa)
AEV28751.1PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II. (341 aa)
AEV28793.1Diaminopropionate ammonia-lyase family; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: diaminopropionate ammonia-lyase family; diaminopropionate ammonia-lyase. (414 aa)
AEV28851.1Alcohol dehydrogenase, class IV; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (889 aa)
AEV28857.1Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. (560 aa)
ilvDPFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (561 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (352 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (423 aa)
AEV28862.1PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa)
leuA2-isopropylmalate synthase, bacterial type; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (538 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
AEV28865.1PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit. (176 aa)
AEV28956.1PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. (201 aa)
AEV28995.1Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; PFAM: Aminotransferase class IV. (270 aa)
AEV29176.1PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain. (429 aa)
oadGSodium pump decarboxylase gamma subunit family protein; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (90 aa)
AEV29205.1Pyruvate/oxaloacetate carboxyltransferase; PFAM: HMGL-like; Conserved carboxylase domain; Biotin-requiring enzyme. (609 aa)
AEV29206.1PFAM: subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit. (398 aa)
AEV29279.1PFAM: subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit. (378 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (311 aa)
accDacetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (259 aa)
AEV29297.1acetyl/propionyl-CoA carboxylase, alpha subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase subunit. (446 aa)
AEV29298.1acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (148 aa)
AEV29349.1PFAM: Alpha-acetolactate decarboxylase; TIGRFAM: alpha-acetolactate decarboxylase. (275 aa)
AEV29509.1Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (557 aa)
AEV29556.1Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: putative selenium metabolism hydrolase. (391 aa)
AEV29651.1Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. (1178 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (632 aa)
AEV30019.1PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (484 aa)
pckG-2Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa)
AEV30273.1PFAM: Fumarate hydratase (Fumerase); TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region. (287 aa)
AEV30274.1PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region. (174 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
AEV30716.1PFAM: Phosphate acetyl/butaryl transferase; TIGRFAM: phosphate acetyltransferase. (334 aa)
AEV30890.1Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (408 aa)
AEV30955.12-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit. (561 aa)
AEV30956.12-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family. (285 aa)
Your Current Organism:
Sphaerochaeta pleomorpha
NCBI taxonomy Id: 158190
Other names: S. pleomorpha str. Grapes, Sphaerochaeta pleomorpha str. Grapes, Sphaerochaeta sp. Grapes, Spirochaeta sp. Grapes
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