STRINGSTRING
AEV31007.1 AEV31007.1 aroE aroE dapA dapA AEV28663.1 AEV28663.1 trpA trpA trpC trpC trpF trpF AEV28749.1 AEV28749.1 AEV28862.1 AEV28862.1 leuA leuA AEV29007.1 AEV29007.1 AEV29086.1 AEV29086.1 hisF hisF hisA hisA AEV29130.1 AEV29130.1 AEV29196.1 AEV29196.1 AEV29205.1 AEV29205.1 AEV29220.1 AEV29220.1 AEV29237.1 AEV29237.1 AEV29308.1 AEV29308.1 AEV29327.1 AEV29327.1 AEV29504.1 AEV29504.1 AEV29516.1 AEV29516.1 AEV29550.1 AEV29550.1 AEV29594.1 AEV29594.1 AEV29605.1 AEV29605.1 AEV29676.1 AEV29676.1 AEV29706.1 AEV29706.1 deoC deoC AEV29755.1 AEV29755.1 AEV28279.1 AEV28279.1 tpiA tpiA AEV28184.1 AEV28184.1 AEV28145.1 AEV28145.1 AEV28087.1 AEV28087.1 AEV28030.1 AEV28030.1 AEV27994.1 AEV27994.1 AEV27961.1 AEV27961.1 AEV27895.1 AEV27895.1 AEV29959.1 AEV29959.1 AEV28392.1 AEV28392.1 AEV30949.1 AEV30949.1 AEV30941.1 AEV30941.1 pdxS pdxS AEV30825.1 AEV30825.1 AEV30703.1 AEV30703.1 AEV30702.1 AEV30702.1 AEV30567.1 AEV30567.1 AEV30521.1 AEV30521.1 AEV30454.1 AEV30454.1 AEV30413.1 AEV30413.1 AEV30408.1 AEV30408.1 AEV30363.1 AEV30363.1 AEV30074.1 AEV30074.1 fda fda
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AEV31007.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (497 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa)
AEV28663.1Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (255 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (205 aa)
AEV28749.1KamA family protein; PFAM: Lysine-2,3-aminomutase; Radical SAM superfamily; TIGRFAM: KamA family protein. (449 aa)
AEV28862.1PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (533 aa)
leuA2-isopropylmalate synthase, bacterial type; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (538 aa)
AEV29007.1KamA family protein; PFAM: Radical SAM superfamily; TIGRFAM: KamA family protein. (356 aa)
AEV29086.1Molybdenum cofactor biosynthesis enzyme; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (325 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (260 aa)
hisAPFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (244 aa)
AEV29130.1PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: N-acetylneuraminate lyase. (295 aa)
AEV29196.1Alpha-galactosidase; PFAM: Melibiase. (785 aa)
AEV29205.1Pyruvate/oxaloacetate carboxyltransferase; PFAM: HMGL-like; Conserved carboxylase domain; Biotin-requiring enzyme. (609 aa)
AEV29220.12-nitropropane dioxygenase-like enzyme; PFAM: 2-nitropropane dioxygenase. (490 aa)
AEV29237.1Pentose-5-phosphate-3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase. (228 aa)
AEV29308.1TIGRFAM: anaerobic sulfatase-maturating enzyme; radical SAM additional 4Fe4S-binding domain. (365 aa)
AEV29327.1PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: N-acetylneuraminate lyase. (308 aa)
AEV29504.1Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: dihydrodipicolinate synthase; Belongs to the DapA family. (306 aa)
AEV29516.1Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: dihydrodipicolinate synthase. (295 aa)
AEV29550.1Lysine 2,3-aminomutase; TIGRFAM: KamA family protein. (710 aa)
AEV29594.1PFAM: Dihydroorotate dehydrogenase; 4Fe-4S binding domain. (410 aa)
AEV29605.1PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (501 aa)
AEV29676.1Phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: Prephenate dehydratase; ACT domain; DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (636 aa)
AEV29706.1PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein. (231 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (221 aa)
AEV29755.1PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase. (320 aa)
AEV28279.1PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
AEV28184.1PFAM: CBS domain; IMP dehydrogenase / GMP reductase domain; TIGRFAM: inosine-5'-monophosphate dehydrogenase. (502 aa)
AEV28145.1PFAM: NADH:flavin oxidoreductase / NADH oxidase family. (451 aa)
AEV28087.1Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily. (361 aa)
AEV28030.1DhnA-type fructose-1,6-bisphosphate aldolase-like enzyme; PFAM: DeoC/LacD family aldolase. (270 aa)
AEV27994.1Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (330 aa)
AEV27961.1PFAM: Lysine-2,3-aminomutase; Radical SAM superfamily; TIGRFAM: KamA family protein; lysine-2,3-aminomutase. (445 aa)
AEV27895.1PFAM: KDPG and KHG aldolase; TIGRFAM: Entner-Doudoroff aldolase. (211 aa)
AEV29959.1Putative TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (333 aa)
AEV28392.1Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (298 aa)
AEV30949.1PFAM: Tryptophan synthase alpha chain. (252 aa)
AEV30941.1Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (488 aa)
pdxSPyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (290 aa)
AEV30825.1PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist. (330 aa)
AEV30703.1PFAM: Dihydroorotate dehydrogenase; TIGRFAM: dihydroorotate dehydrogenase (subfamily 1) family protein; Belongs to the dihydroorotate dehydrogenase family. (578 aa)
AEV30702.1Orotidine 5''-phosphate decarboxylase, subfamily 2; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2. (293 aa)
AEV30567.1Hypothetical protein; TIGRFAM: radical SAM additional 4Fe4S-binding domain. (422 aa)
AEV30521.1Pyruvate formate lyase activating protein-like uncharacterized Fe-S protein; PFAM: Radical SAM superfamily. (341 aa)
AEV30454.123S rRNA m2A2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. (358 aa)
AEV30413.1Pyruvate-formate lyase-activating enzyme; PFAM: Radical SAM superfamily. (327 aa)
AEV30408.1Dihydrodipicolinate synthase/N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase family; Belongs to the DapA family. (307 aa)
AEV30363.1PFAM: Transaldolase; TIGRFAM: fructose-6-phosphate aldolase, TalC/MipB family. (225 aa)
AEV30074.1PFAM: NADH:flavin oxidoreductase / NADH oxidase family. (341 aa)
fdaPFAM: Fructose-bisphosphate aldolase class-I. (295 aa)
Your Current Organism:
Sphaerochaeta pleomorpha
NCBI taxonomy Id: 158190
Other names: S. pleomorpha str. Grapes, Sphaerochaeta pleomorpha str. Grapes, Sphaerochaeta sp. Grapes, Spirochaeta sp. Grapes
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