(18 nodes) Thiamin diphosphate-binding fold network (Sphaerochaeta pleomorpha)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AEV29509.1	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (557 aa)
	AEV29820.1	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain. (277 aa)
	AEV29821.1	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (315 aa)
	AEV30200.1	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa)
	AEV30287.1	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (313 aa)
	AEV29651.1	Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. (1178 aa)
	AEV29803.1	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain. (296 aa)
	AEV29804.1	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (305 aa)
	AEV30288.1	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain. (273 aa)
	AEV30351.1	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (818 aa)
	AEV30882.1	Acetolactate synthase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family. (621 aa)
	AEV30955.1	2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit. (561 aa)
	AEV30956.1	2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family. (285 aa)
	AEV29271.1	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain. (280 aa)
	AEV29270.1	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (312 aa)
	AEV29139.1	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (659 aa)
	AEV28857.1	Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. (560 aa)
	AEV29366.1	Phosphonopyruvate decarboxylase; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: phosphonopyruvate decarboxylase. (380 aa)

Your Current Organism:

Sphaerochaeta pleomorpha

NCBI taxonomy Id: 158190
Other names: S. pleomorpha str. Grapes, Sphaerochaeta pleomorpha str. Grapes, Sphaerochaeta sp. Grapes, Spirochaeta sp. Grapes

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEV28857.1	AEV29509.1	SpiGrapes_1033	SpiGrapes_1710	Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.	Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.	0.920
AEV28857.1	AEV29651.1	SpiGrapes_1033	SpiGrapes_1857	Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric.	0.951
AEV28857.1	AEV30955.1	SpiGrapes_1033	SpiGrapes_3210	Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.	2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit.	0.932
AEV28857.1	AEV30956.1	SpiGrapes_1033	SpiGrapes_3211	Acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.	2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family.	0.912
AEV29139.1	AEV29651.1	SpiGrapes_1326	SpiGrapes_1857	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric.	0.602
AEV29139.1	AEV30200.1	SpiGrapes_1326	SpiGrapes_2432	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.508
AEV29139.1	AEV30351.1	SpiGrapes_1326	SpiGrapes_2590	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	0.999
AEV29139.1	AEV30955.1	SpiGrapes_1326	SpiGrapes_3210	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Dehydrogenase E1 component; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit.	0.523
AEV29270.1	AEV29271.1	SpiGrapes_1459	SpiGrapes_1460	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain.	0.999
AEV29270.1	AEV29651.1	SpiGrapes_1459	SpiGrapes_1857	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric.	0.813
AEV29270.1	AEV29803.1	SpiGrapes_1459	SpiGrapes_2016	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain.	0.998
AEV29270.1	AEV29804.1	SpiGrapes_1459	SpiGrapes_2017	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	0.911
AEV29270.1	AEV29820.1	SpiGrapes_1459	SpiGrapes_2033	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain.	0.998
AEV29270.1	AEV29821.1	SpiGrapes_1459	SpiGrapes_2034	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	0.918
AEV29270.1	AEV30200.1	SpiGrapes_1459	SpiGrapes_2432	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.920
AEV29270.1	AEV30287.1	SpiGrapes_1459	SpiGrapes_2526	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	0.911
AEV29270.1	AEV30288.1	SpiGrapes_1459	SpiGrapes_2527	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain.	0.998
AEV29270.1	AEV30955.1	SpiGrapes_1459	SpiGrapes_3210	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit.	0.807
AEV29270.1	AEV30956.1	SpiGrapes_1459	SpiGrapes_3211	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family.	0.800
AEV29271.1	AEV29270.1	SpiGrapes_1460	SpiGrapes_1459	Transketolase, beta subunit; PFAM: Transketolase, thiamine diphosphate binding domain.	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	0.999