(50 nodes) Mismatch repair network (Diaporthe helianthi)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DHEL01_v200854	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
	DHEL01_v212976	UvrD_C_2 domain-containing protein. (756 aa)
	DHEL01_v211973	Helicase ATP-binding domain-containing protein. (824 aa)
	DHEL01_v211838	Activator 1 38 kDa subunit. (352 aa)
	DHEL01_v211698	Exonuclease 1. (767 aa)
	DHEL01_v211410	Activator 1 41 kDa subunit. (380 aa)
	DHEL01_v210932	DNA ligase. (892 aa)
	DHEL01_v210837	DNA polymerase. (1103 aa)
	DHEL01_v210613	AAA domain-containing protein. (1216 aa)
	DHEL01_v209800	ANK_REP_REGION domain-containing protein. (695 aa)
	DHEL01_v209802	Replication factor C. (392 aa)
	DHEL01_v208320	MutL ortholog-1. (728 aa)
	DHEL01_v207844	Uncharacterized protein. (227 aa)
	DHEL01_v207822	DNA polymerase delta. (195 aa)
	DHEL01_v207488	Uncharacterized protein. (495 aa)
	DHEL01_v207196	Uncharacterized protein; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. (275 aa)
	DHEL01_v207098	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (167 aa)
	DHEL01_v207008	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (609 aa)
	DHEL01_v206836	Replication factor C subunit 4. (359 aa)
	DHEL01_v206531	MutS domain V. (905 aa)
	DHEL01_v206212	C2H2-type domain-containing protein. (723 aa)
	DHEL01_v206213	Uncharacterized protein. (1091 aa)
	DHEL01_v205762	Uncharacterized protein. (276 aa)
	DHEL01_v205457	DNA mismatch repair protein pms1. (1142 aa)
	DHEL01_v204812	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1246 aa)
	DHEL01_v204794	Replication factor C subunit 1. (1034 aa)
	DHEL01_v204685	MutS domain V. (1010 aa)
	DHEL01_v204718	HET domain-containing protein. (390 aa)
	DHEL01_v204579	DNA ligase. (883 aa)
	DHEL01_v204522	Uncharacterized protein. (622 aa)
	DHEL01_v204012	DNA mismatch repair protein MLH3. (976 aa)
	DHEL01_v203882	UDP-galactopyranose mutase. (506 aa)
	DHEL01_v203573	DNA mismatch repair protein mutL. (966 aa)
	DHEL01_v203358	MutS-like protein 2-like protein; Component of the post-replicative DNA mismatch repair system (MMR). (924 aa)
	DHEL01_v203125	RNA exonuclease 4. (327 aa)
	DHEL01_v202890	Nicotianamine synthase. (360 aa)
	DHEL01_v202646	Cell cycle control protein cwf16. (315 aa)
	DHEL01_v202421	HET domain-containing protein. (658 aa)
	DHEL01_v202329	Formamidase. (331 aa)
	DHEL01_v202189	DNA polymerase subunit delta-2. (510 aa)
	DHEL01_v201958	Mutagen-sensitive-50. (1102 aa)
	DHEL01_v201734	DNA mismatch repair protein MSH5. (788 aa)
	DHEL01_v201588	Replication factor A protein 3. (106 aa)
	DHEL01_v201530	Uncharacterized protein. (194 aa)
	DHEL01_v201376	Zds_C domain-containing protein. (894 aa)
	DHEL01_v201051	TPR domain-containing protein. (508 aa)
	DHEL01_v200893	Uncharacterized protein. (413 aa)
	DHEL01_v200853	Vezatin domain-containing protein. (643 aa)
	DHEL01_v200526	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1129 aa)
	DHEL01_v200061	Uncharacterized protein. (141 aa)

Your Current Organism:

Diaporthe helianthi

NCBI taxonomy Id: 158607
Other names: CBS 592.81, D. helianthi, Phomopsis helianthi, Phomopsis sp. CBS 187.87

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHEL01_v200061	DHEL01_v200853	A0A2P5IGB2	A0A2P5IE31	Uncharacterized protein.	Vezatin domain-containing protein.	0.564
DHEL01_v200061	DHEL01_v200854	A0A2P5IGB2	A0A2P5IE50	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.564
DHEL01_v200061	DHEL01_v203125	A0A2P5IGB2	A0A2P5I7K5	Uncharacterized protein.	RNA exonuclease 4.	0.468
DHEL01_v200061	DHEL01_v204812	A0A2P5IGB2	A0A2P5I2R1	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.654
DHEL01_v200061	DHEL01_v205762	A0A2P5IGB2	A0A2P5I005	Uncharacterized protein.	Uncharacterized protein.	0.507
DHEL01_v200061	DHEL01_v207008	A0A2P5IGB2	A0A2P5HWG9	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.656
DHEL01_v200061	DHEL01_v207196	A0A2P5IGB2	A0A2P5HW06	Uncharacterized protein.	Uncharacterized protein; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.	0.468
DHEL01_v200061	DHEL01_v211698	A0A2P5IGB2	A0A2P5HI29	Uncharacterized protein.	Exonuclease 1.	0.499
DHEL01_v200526	DHEL01_v200853	A0A2P5IEZ8	A0A2P5IE31	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Vezatin domain-containing protein.	0.942
DHEL01_v200526	DHEL01_v200854	A0A2P5IEZ8	A0A2P5IE50	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.942
DHEL01_v200526	DHEL01_v200893	A0A2P5IEZ8	A0A2P5IDX0	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Uncharacterized protein.	0.414
DHEL01_v200526	DHEL01_v201734	A0A2P5IEZ8	A0A2P5IBI5	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA mismatch repair protein MSH5.	0.967
DHEL01_v200526	DHEL01_v201958	A0A2P5IEZ8	A0A2P5IAV3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Mutagen-sensitive-50.	0.416
DHEL01_v200526	DHEL01_v202329	A0A2P5IEZ8	A0A2P5I9U0	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Formamidase.	0.884
DHEL01_v200526	DHEL01_v203358	A0A2P5IEZ8	A0A2P5I6X1	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	MutS-like protein 2-like protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.999
DHEL01_v200526	DHEL01_v203573	A0A2P5IEZ8	A0A2P5I6A2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA mismatch repair protein mutL.	0.950
DHEL01_v200526	DHEL01_v204012	A0A2P5IEZ8	A0A2P5I526	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA mismatch repair protein MLH3.	0.920
DHEL01_v200526	DHEL01_v204579	A0A2P5IEZ8	A0A2P5I3F4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA ligase.	0.412
DHEL01_v200526	DHEL01_v204685	A0A2P5IEZ8	A0A2P5I346	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	MutS domain V.	0.967
DHEL01_v200526	DHEL01_v204812	A0A2P5IEZ8	A0A2P5I2R1	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.991