STRINGSTRING
ALI51691.1 ALI51691.1 recF recF ALI51697.1 ALI51697.1 dnaX dnaX recR recR ALI52019.1 ALI52019.1 ruvA ruvA ruvB ruvB polA polA priA priA recG recG polC polC ALI52431.1 ALI52431.1 recO recO ALI52703.1 ALI52703.1 ALI52796.1 ALI52796.1 recD2 recD2 ALI52912.1 ALI52912.1 recA recA ALI53141.1 ALI53141.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALI51691.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
recFRecombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (375 aa)
ALI51697.1Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (172 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (595 aa)
recRRecombinase; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
ALI52019.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
ruvAATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (196 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (338 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (887 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (799 aa)
recGATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (676 aa)
polCDNA polymerase III; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1436 aa)
ALI52431.1Single-stranded DNA exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (757 aa)
recODNA recombination protein RecO; Involved in DNA repair and RecF pathway recombination. (250 aa)
ALI52703.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1035 aa)
ALI52796.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
recD2Exodeoxyribonuclease V subunit alpha; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (783 aa)
ALI52912.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (365 aa)
ALI53141.13'-5' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
Your Current Organism:
Lactobacillus helveticus
NCBI taxonomy Id: 1587
Other names: ATCC 15009, Bacillus casei e, Bacillus e, CCUG 30139, CIP 103146, Caseobacterium e, DSM 20075, IFO 15019, L. helveticus, LMG 13555, LMG 22464 [[Lactobacillus suntoryeus]], LMG 6413, LMG:13555, LMG:22464 [[Lactobacillus suntoryeus]], LMG:6413, Lactobacillus helveticum, Lactobacillus sp. NCIM 2126, Lactobacillus sp. NCIM 2733, Lactobacillus suntoryeus, Lactobacillus suntoryeus Cachat and Priest 2005, Lactobacterium helveticum, NBRC 15019, NCIMB 14005 [[Lactobacillus suntoryeus]], NRRL B-4526, Plocamobacterium helveticum, Thermobacterium helveticum, strain SA [[Lactobacillus suntoryeus]]
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