(14 nodes) Mixed, incl. tRNA threonylcarbamoyladenosine modification, and Uracil DNA N-glycosylase activity network (Dechloromonas aromatica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Daro_0444	Conserved hypothetical protein. (98 aa)
	Daro_0450	Small multidrug resistance protein. (109 aa)
	Daro_0452	Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (331 aa)
	tsaD	O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (358 aa)
	Daro_0842	Putative signal transduction protein containing EAL and modified HD-GYP domains. (389 aa)
	tilS	PP-loop; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (323 aa)
	Daro_0848	Beta-lactamase-like protein. (255 aa)
	Daro_1981	Peptidase M22, glycoprotease. (229 aa)
	Daro_1982	[SSU ribosomal protein S18P]-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (153 aa)
	Daro_1983	Phage SPO1 DNA polymerase-related protein. (260 aa)
	Daro_2037	Uracil-DNA glycosylase superfamily. (215 aa)
	Daro_2201	ErfK/YbiS/YcfS/YnhG. (160 aa)
	tadA	tRNA-adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
	Daro_3050	Protein of unknown function UPF0079. (153 aa)

Your Current Organism:

Dechloromonas aromatica

NCBI taxonomy Id: 159087
Other names: D. aromatica RCB, Dechloromonas aromatica RCB, Dechloromonas aromatica str. RCB, Dechloromonas sp. RCB

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Daro_0450	Daro_0452	Daro_0450	Daro_0452	Small multidrug resistance protein.	Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	0.778
Daro_0452	Daro_0450	Daro_0452	Daro_0450	Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	Small multidrug resistance protein.	0.778
Daro_0452	Daro_1981	Daro_0452	Daro_1981	Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	Peptidase M22, glycoprotease.	0.622
Daro_0452	Daro_3050	Daro_0452	Daro_3050	Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	Protein of unknown function UPF0079.	0.622
Daro_0452	tsaD	Daro_0452	Daro_0530	Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.	0.647
Daro_0842	tilS	Daro_0842	Daro_0845	Putative signal transduction protein containing EAL and modified HD-GYP domains.	PP-loop; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.	0.476
Daro_0848	tilS	Daro_0848	Daro_0845	Beta-lactamase-like protein.	PP-loop; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.	0.546
Daro_1981	Daro_0452	Daro_1981	Daro_0452	Peptidase M22, glycoprotease.	Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.	0.622
Daro_1981	Daro_1982	Daro_1981	Daro_1982	Peptidase M22, glycoprotease.	[SSU ribosomal protein S18P]-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.	0.954
Daro_1981	Daro_1983	Daro_1981	Daro_1983	Peptidase M22, glycoprotease.	Phage SPO1 DNA polymerase-related protein.	0.893
Daro_1981	Daro_2037	Daro_1981	Daro_2037	Peptidase M22, glycoprotease.	Uracil-DNA glycosylase superfamily.	0.439
Daro_1981	Daro_3050	Daro_1981	Daro_3050	Peptidase M22, glycoprotease.	Protein of unknown function UPF0079.	0.989
Daro_1981	tadA	Daro_1981	Daro_2202	Peptidase M22, glycoprotease.	tRNA-adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.	0.583
Daro_1981	tilS	Daro_1981	Daro_0845	Peptidase M22, glycoprotease.	PP-loop; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.	0.482
Daro_1981	tsaD	Daro_1981	Daro_0530	Peptidase M22, glycoprotease.	O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.	0.968
Daro_1982	Daro_1981	Daro_1982	Daro_1981	[SSU ribosomal protein S18P]-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.	Peptidase M22, glycoprotease.	0.954
Daro_1982	Daro_1983	Daro_1982	Daro_1983	[SSU ribosomal protein S18P]-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.	Phage SPO1 DNA polymerase-related protein.	0.844
Daro_1983	Daro_1981	Daro_1983	Daro_1981	Phage SPO1 DNA polymerase-related protein.	Peptidase M22, glycoprotease.	0.893
Daro_1983	Daro_1982	Daro_1983	Daro_1982	Phage SPO1 DNA polymerase-related protein.	[SSU ribosomal protein S18P]-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.	0.844
Daro_1983	Daro_2037	Daro_1983	Daro_2037	Phage SPO1 DNA polymerase-related protein.	Uracil-DNA glycosylase superfamily.	0.937