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| | Daro_0077 | L-glutamine synthetase. (453 aa) |
| | Daro_0086 | hydroxymethylglutaryl-CoA lyase. (301 aa) |
| | Daro_0096 | Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region:Acyl-CoA dehydrogenase, N-terminal. (378 aa) |
| | Daro_0098 | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | Daro_0176 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | Daro_0177 | Acetoacetyl-CoA synthase. (651 aa) |
| | Daro_0217 | Glutamate synthase (NADH) large subunit. (1544 aa) |
| | Daro_0218 | Glutamate synthase (NADH) small subunit. (488 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the t [...] (452 aa) |
| | Daro_0226 | AMP-dependent synthetase and ligase. (545 aa) |
| | Daro_0227 | Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region. (592 aa) |
| | Daro_0228 | FAD dependent oxidoreductase:Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (547 aa) |
| | Daro_0233 | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (546 aa) |
| | icmF | Methylmalonyl-CoA mutase, N-terminal:Methylmalonyl-CoA mutase, C-terminal; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1116 aa) |
| | Daro_0267 | Pyruvate ferredoxin/flavodoxin oxidoreductase. (1150 aa) |
| | Daro_0268 | FAD linked oxidase, C-terminal:FAD linked oxidase, N-terminal. (462 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (618 aa) |
| | Daro_0359 | Zinc-containing alcohol dehydrogenase superfamily. (327 aa) |
| | Daro_0372 | 3-hydroxyacyl-CoA dehydrogenase. (519 aa) |
| | Daro_0375 | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | Daro_0382 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | Daro_0383 | Enoyl-CoA hydratase/isomerase. (259 aa) |
| | Daro_0440 | Dihydrolipoamide dehydrogenase. (591 aa) |
| | Daro_0441 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (546 aa) |
| | Daro_0442 | 2-oxo-acid dehydrogenase E1 component homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (891 aa) |
| | Daro_0446 | Indolepyruvate oxidoreductase subunit IorA; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (624 aa) |
| | Daro_0447 | Pyruvate ferredoxin/flavodoxin oxidoreductase. (203 aa) |
| | Daro_0457 | Propionate CoA-transferase. (667 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (568 aa) |
| | Daro_0539 | Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region:Acyl-CoA dehydrogenase, N-terminal. (391 aa) |
| | Daro_0558 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa) |
| | glgA | Glycogen synthase (ADP-glucose); Synthesizes alpha-1,4-glucan chains using ADP-glucose. (485 aa) |
| | pgi | Glucose-6-phosphate isomerase. (526 aa) |
| | Daro_0582 | Alpha-glucan phosphorylase. (856 aa) |
| | Daro_0583 | Alpha-amylase. (657 aa) |
| | Daro_0584 | Glycoside hydrolase, family 57. (551 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (440 aa) |
| | glgB | 1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (621 aa) |
| | glk | Glucokinase; Belongs to the bacterial glucokinase family. (309 aa) |
| | Daro_0602 | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (218 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa) |
| | Daro_0666 | Phosphate acetyl/butaryl transferase:Malic enzyme, N-terminal:Malic enzyme, NAD-binding protein; Belongs to the malic enzymes family. (759 aa) |
| | Daro_0669 | Protein of unknown function DUF224, cysteine-rich region. (243 aa) |
| | Daro_0670 | 4Fe-4S ferredoxin, iron-sulfur binding protein. (480 aa) |
| | Daro_0671 | Aldehyde dehydrogenase. (232 aa) |
| | Daro_0672 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein. (318 aa) |
| | Daro_0673 | Protein of unknown function DUF162. (213 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (332 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (212 aa) |
| | leuB1 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (350 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | Daro_0896 | AMP-dependent synthetase and ligase. (552 aa) |
| | glmM | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (450 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa) |
| | Daro_0963 | NUDIX hydrolase. (180 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (393 aa) |
| | Daro_0975 | Phosphate butyryltransferase. (472 aa) |
| | Daro_1008 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (506 aa) |
| | Daro_1021 | butyryl-CoA:acetate CoA transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (463 aa) |
| | acyP | Acylphosphatase. (92 aa) |
| | Daro_1202 | Zinc-containing alcohol dehydrogenase superfamily. (331 aa) |
| | Daro_1204 | propionyl-CoA synthetase. (630 aa) |
| | Daro_1211 | Electron transfer flavoprotein beta-subunit. (249 aa) |
| | Daro_1212 | Electron transfer flavoprotein beta-subunit:Electron transfer flavoprotein, alpha subunit. (310 aa) |
| | Daro_1215 | Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region. (593 aa) |
| | Daro_1398 | Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (378 aa) |
| | Daro_1444 | Phosphoglucomutase, alpha-D-glucose phosphate-specific. (545 aa) |
| | Daro_1526 | Zinc-containing alcohol dehydrogenase superfamily. (327 aa) |
| | Daro_1544 | Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, N-terminal. (784 aa) |
| | Daro_1545 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (435 aa) |
| | Daro_1547 | 3-hydroxyacyl-CoA dehydrogenase. (637 aa) |
| | Daro_1549 | 3-hydroxyacyl-CoA dehydrogenase. (799 aa) |
| | Daro_1550 | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa) |
| | Daro_1555 | Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region. (597 aa) |
| | Daro_1619 | Acetolactate synthase, small subunit. (103 aa) |
| | Daro_1620 | Acetolactate synthase, large subunit. (556 aa) |
| | Daro_1627 | Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (510 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (918 aa) |
| | Daro_1762 | L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family. (578 aa) |
| | Daro_1763 | D-lactate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding:FAD linked oxidase, C-terminal:FAD linked oxidase, N-terminal. (923 aa) |
| | Daro_1764 | Iron-sulfur cluster binding protein. (480 aa) |
| | Daro_1765 | Protein of unknown function DUF162. (222 aa) |
| | Daro_1766 | Protein of unknown function DUF224, cysteine-rich region. (260 aa) |
| | Daro_1767 | Transcriptional regulator, GntR family. (255 aa) |
| | Daro_1768 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (791 aa) |
| | Daro_1774 | Malonyl-CoA decarboxylase. (442 aa) |
| | Daro_1776 | Succinate dehydrogenase subunit B. (252 aa) |
| | Daro_1777 | Succinate dehydrogenase subunit A. (659 aa) |
| | Daro_1778 | Fumarate reductase respiratory complex, transmembrane subunit. (272 aa) |
| | Daro_1809 | Glycine cleavage H-protein. (147 aa) |
| | Daro_1936 | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (548 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (366 aa) |
| | Daro_2063 | D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase. (788 aa) |
| | Daro_2068 | Aldehyde dehydrogenase. (542 aa) |
| | Daro_2069 | 6-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (479 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (487 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (232 aa) |
| | Daro_2096 | Formate acetyltransferase. (751 aa) |
| | Daro_2097 | Radical SAM; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (264 aa) |
| | Daro_2098 | Phosphate butyryltransferase. (493 aa) |
| | ackA-2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa) |
| | Daro_2100 | Formate/nitrite transporter. (316 aa) |
| | Daro_2117 | Pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa) |
| | Daro_2118 | Glycerate 2-kinase. (426 aa) |
| | Daro_2350 | 3-hydroxyacyl-CoA dehydrogenase. (705 aa) |
| | Daro_2351 | AMP-dependent synthetase and ligase. (517 aa) |
| | Daro_2352 | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | Daro_2353 | Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central region:Acyl-CoA dehydrogenase, N-terminal. (378 aa) |
| | Daro_2354 | Enoyl-CoA hydratase. (266 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | Daro_2389 | Mannose-6-phosphate isomerase, type 2 / mannose-1-phosphate guanylyltransferase (GDP). (479 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (963 aa) |
| | Daro_2708 | AMP-dependent synthetase and ligase. (576 aa) |
| | Daro_2721 | Glu/Leu/Phe/Val dehydrogenase, C terminal:Glu/Leu/Phe/Val dehydrogenase, dimerization region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (427 aa) |
| | Daro_2733 | Aldose 1-epimerase; Belongs to the glucose-6-phosphate 1-epimerase family. (281 aa) |
| | Daro_2777 | Putative pyruvate ferredoxin/flavodoxin oxidoreductase. (1186 aa) |
| | Daro_2807 | Acetyl-CoA hydrolase/transferase. (503 aa) |
| | Daro_2840 | Pyruvate:ferredoxin (flavodoxin) oxidoreductase. (1212 aa) |
| | Daro_2857 | Dihydrolipoamide dehydrogenase. (474 aa) |
| | Daro_2858 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (407 aa) |
| | Daro_2859 | 2-oxoglutarate dehydrogenase E1 component. (945 aa) |
| | Daro_2860 | Citrate synthase; Belongs to the citrate synthase family. (432 aa) |
| | Daro_2862 | Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa) |
| | Daro_2863 | Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (594 aa) |
| | Daro_2864 | Succinate dehydrogenase subunit D. (115 aa) |
| | Daro_2865 | Succinate dehydrogenase subunit C. (129 aa) |
| | mdh | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa) |
| | Daro_2882 | Aconitase; Belongs to the aconitase/IPM isomerase family. (862 aa) |
| | ackA-3 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (772 aa) |
| | fumC | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa) |
| | Daro_3022 | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | Daro_3074 | Acetolactate synthase, small subunit. (163 aa) |
| | Daro_3075 | Acetolactate synthase, large subunit. (566 aa) |
| | Daro_3098 | Isocitrate lyase. (432 aa) |
| | Daro_3101 | Malate synthase A; Belongs to the malate synthase family. (532 aa) |
| | Daro_3119 | Isocitrate dehydrogenase (NADP). (413 aa) |
| | Daro_3120 | Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (745 aa) |
| | pfp | Pyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (419 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | Daro_3299 | Phosphomannomutase. (458 aa) |
| | Daro_3313 | 4Fe-4S ferredoxin, iron-sulfur binding:Protein of unknown function DUF224, cysteine-rich region. (411 aa) |
| | Daro_3314 | FAD linked oxidase, N-terminal. (349 aa) |
| | Daro_3315 | FAD linked oxidase, C-terminal:FAD linked oxidase, N-terminal. (496 aa) |
| | Daro_3317 | Xylose isomerase-like TIM barrel; Belongs to the hyi family. (257 aa) |
| | Daro_3320 | Enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (273 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | Daro_3368 | Fumarylacetoacetate (FAA) hydrolase. (233 aa) |
| | Daro_3444 | LipQ; Similar to lipase/esterase. (274 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (226 aa) |
| | Daro_3483 | Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (233 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (232 aa) |
| | fbp1 | D-fructose 1,6-bisphosphatase. (338 aa) |
| | Daro_3591 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (668 aa) |
| | Daro_3592 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (342 aa) |
| | Daro_3593 | Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (349 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (393 aa) |
| | Daro_3595 | Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | Daro_3596 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | Daro_3624 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (345 aa) |
| | Daro_3625 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (339 aa) |
| | Daro_3626 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (690 aa) |
| | Daro_3627 | Phosphoribulokinase/uridine kinase. (290 aa) |
| | fbp2 | D-fructose 1,6-bisphosphatase. (357 aa) |
| | Daro_3629 | HAD-superfamily hydrolase subfamily IA, variant 3. (233 aa) |
| | Daro_3630 | Hypothetical protein. (121 aa) |
| | cbbM | Ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type II subfamily. (459 aa) |
| | Daro_3700 | Dehydrogenase, E1 component. (320 aa) |
| | Daro_3701 | Transketolase, central region:Transketolase, C-terminal. (337 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | Daro_3748 | Succinate semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (484 aa) |
| | Daro_3763 | L-glutamine synthetase. (471 aa) |
| | leuB2 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (358 aa) |
| | Daro_3804 | 2,4-dihydroxyhept-2-enedioate aldolase; Belongs to the HpcH/HpaI aldolase family. (266 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (607 aa) |
| | Daro_3938 | acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa) |
| | Daro_3939 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa) |
| | Daro_3943 | Allosteric NADP-dependent malic enzyme. (758 aa) |
| | Daro_4003 | Acetyl-CoA carboxylase, biotin carboxylase. (667 aa) |
| | Daro_4004 | propionyl-CoA carboxylase carboxyltransferase subunit. (511 aa) |
| | Daro_4005 | methylmalonyl-CoA mutase metallochaperone MeaB. (329 aa) |
| | Daro_4006 | methylmalonyl-CoA mutase. (716 aa) |
| | Daro_4012 | Enoyl-CoA hydratase/isomerase. (258 aa) |
| | ilvE-2 | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (510 aa) |
