STRINGSTRING
pckA pckA ALC14967.1 ALC14967.1 lpdA-2 lpdA-2 aspA aspA por-1 por-1 tkt tkt por-2 por-2 ALC15184.1 ALC15184.1 ALC15278.1 ALC15278.1 tklA tklA tklB tklB ALC15539.1 ALC15539.1 gdhA gdhA gltA gltA deoC deoC deoB deoB ALC15941.1 ALC15941.1 pyc pyc pckA-2 pckA-2 fbp fbp korC korC korB korB korA korA korD korD mdh mdh icd icd acnB acnB ALC16366.1 ALC16366.1 ALC16370.1 ALC16370.1 frdC frdC frdA frdA frdB frdB eno eno pgi pgi ppsA ppsA vorD vorD vorA vorA vorB vorB vorC vorC tpi tpi pgk pgk gapA gapA glyA glyA rpiB rpiB pfk-1 pfk-1 maeB maeB glnA glnA ALC16889.1 ALC16889.1 fumB fumB pfk-2 pfk-2 gcvP1 gcvP1 gcvP2 gcvP2 gcvH gcvH gcvT gcvT folD folD ALC17350.1 ALC17350.1 ALC17451.1 ALC17451.1 acnA acnA ALC17517.1 ALC17517.1 pdhB pdhB pdhA pdhA lpdA-1 lpdA-1 bkdA bkdA bkdB bkdB bkdF bkdF ALC17628.1 ALC17628.1 ALC17703.1 ALC17703.1 ALC17704.1 ALC17704.1 ALC17705.1 ALC17705.1 ppdK ppdK ALC17812.1 ALC17812.1 ALC17813.1 ALC17813.1 ALC17814.1 ALC17814.1 gltS gltS sucB sucB sucA sucA rpe rpe sucD sucD sucC sucC tal tal ppc ppc pyk pyk
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (524 aa)
ALC14967.1Putative amidohydrolase. (263 aa)
lpdA-2Dihydrolipoamide dehydrogenase. (465 aa)
aspAFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
por-1Pyruvate-flavodoxin oxidoreductase. (1194 aa)
tktTransketolase; Belongs to the transketolase family. (665 aa)
por-2Pyruvate-flavodoxin oxidoreductase. (1185 aa)
ALC15184.1Na+-transporting malonate decarboxylase, carboxybiotin decarboxylase subunit; Beta subunit of the biotin-dependent malonate decarboxylase multienzyme complex (EC 7.2.4.4). Acts as an integral membrane-bound carboxybiotin protein decarboxylase by releasing the carboxyl group of the carboxylated biotin carrier MADF. The free energy of the decarboxylation reaction is used to pump Na(+) out of the cell. (402 aa)
ALC15278.1Aldehyde dehydrogenase. (542 aa)
tklATransketolase subunit A. (275 aa)
tklBTransketolase subunit B. (312 aa)
ALC15539.1Aconitase. (646 aa)
gdhAGlutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (449 aa)
gltACitrate synthase; Belongs to the citrate synthase family. (443 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (392 aa)
ALC15941.1Glutamate/leucine/phenylalanine/valine dehydrogenase. (1007 aa)
pycPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1150 aa)
pckA-2Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa)
fbpD-fructose 1,6-bisphosphatase; Belongs to the FBPase class 1 family. (313 aa)
korC2-oxoglutarate:ferredoxin oxidoreductase, gamma subunit. (181 aa)
korB2-oxoglutarate:ferredoxin oxidoreductase, beta subunit. (273 aa)
korA2-oxoglutarate:ferredoxin oxidoreductase, alpha subunit. (376 aa)
korDTungsten formylmethanofuran dehydrogenase. (65 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (318 aa)
icdIsocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (741 aa)
acnBAconitase; Belongs to the aconitase/IPM isomerase family. (843 aa)
ALC16366.1NAD-specific glutamate dehydrogenase. (1594 aa)
ALC16370.1Putative pyridoxal-dependent aspartate 1-decarboxylase. (559 aa)
frdCSuccinate dehydrogenase subunit C. (222 aa)
frdASuccinate dehydrogenase subunit A. (638 aa)
frdBSuccinate dehydrogenase subunit B. (249 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (464 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (796 aa)
vorDPutative ferredoxin; 4Fe-4S dicluster domain. (73 aa)
vorAPyruvate:ferredoxin oxidoreductase, alpha subunit. (354 aa)
vorBPyruvate:ferredoxin oxidoreductase, beta subunit. (250 aa)
vorCPyruvate:ferredoxin oxidoreductase, gamma subunit. (194 aa)
tpiTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
rpiBRibose-5-phosphate isomerase. (151 aa)
pfk-16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (362 aa)
maeBAllosteric NADP-dependent malic enzyme. (752 aa)
glnAL-glutamine synthetase. (469 aa)
ALC16889.1Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (713 aa)
fumBFumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (539 aa)
pfk-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (307 aa)
gcvP1Glycine dehydrogenase, C-terminal domain; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (484 aa)
gcvP2Glycine dehydrogenase, N-terminal domain; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (449 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
ALC17350.1Hypothetical protein; DUF1451 superfamily. (166 aa)
ALC17451.1Fructose-1,6-bisphosphatase, class II. (317 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (915 aa)
ALC17517.1Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component. (494 aa)
pdhBPyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (323 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (327 aa)
lpdA-1Dihydrolipoamide dehydrogenase. (466 aa)
bkdAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (358 aa)
bkdBPyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. (325 aa)
bkdFPyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component. (391 aa)
ALC17628.1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (371 aa)
ALC17703.1Fructose-1,6-bisphosphate aldolase. (326 aa)
ALC17704.1Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa)
ALC17705.14Fe-4S ferredoxin. (515 aa)
ppdKPyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (886 aa)
ALC17812.14Fe-4S ferredoxin. (769 aa)
ALC17813.1Ferredoxin-dependent glutamate synthase, GltB2 subunit; Belongs to the glutamate synthase family. (547 aa)
ALC17814.1Ferredoxin-dependent glutamate synthase, GltB1 subunit. (368 aa)
gltSGlutamate synthase. (1513 aa)
sucB2-oxoglutarate dehydrogenase E2 component. (393 aa)
sucA2-oxoglutarate dehydrogenase E1 component. (893 aa)
rpeRibulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (928 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (482 aa)
Your Current Organism:
Desulfuromonas soudanensis
NCBI taxonomy Id: 1603606
Other names: D. soudanensis, Desulfuromonas sp. WTL, strain WTL
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