STRINGSTRING
BLEM_1614 BLEM_1614 coaD coaD BLEM_1593 BLEM_1593 BLEM_1498 BLEM_1498 glyA glyA folD folD coaE coaE guaA guaA BLEM_1213 BLEM_1213 adk adk thyA thyA BLEM_0448 BLEM_0448 tadA tadA dcd dcd dut dut guaB guaB BLEM_0651 BLEM_0651 BLEM_0652 BLEM_0652 apt apt purH purH pyrH pyrH BLEM_2094 BLEM_2094 tmk tmk BLEM_1152 BLEM_1152 BLEM_1134 BLEM_1134 BLEM_0831 BLEM_0831 BLEM_0865 BLEM_0865 gmk gmk BLEM_0813 BLEM_0813 carB carB carA carA purT purT purC purC BLEM_0783 BLEM_0783 purF purF purM purM purD purD purK purK purE purE coaX coaX pyrG pyrG xpt xpt BLEM_1923 BLEM_1923 BLEM_1969 BLEM_1969 purA purA upp upp pyrE pyrE pyrD pyrD BLEM_2028 BLEM_2028 pyrF pyrF BLEM_2026 BLEM_2026 BLEM_2025 BLEM_2025 pyrB pyrB BLEM_1772 BLEM_1772
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BLEM_1614Unannotated protein. (243 aa)
coaDUnannotated protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa)
BLEM_1593Unannotated protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (232 aa)
BLEM_1498Unannotated protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (382 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (435 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa)
coaEUnannotated protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (215 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (520 aa)
BLEM_1213Unannotated protein. (223 aa)
adkUnannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (190 aa)
thyAUnannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (290 aa)
BLEM_0448Unannotated protein; Belongs to the dihydrofolate reductase family. (219 aa)
tadAUnannotated protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (221 aa)
dcdUnannotated protein; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (193 aa)
dutUnannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (159 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (510 aa)
BLEM_0651Unannotated protein. (799 aa)
BLEM_0652Unannotated protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (233 aa)
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (193 aa)
purHUnannotated protein. (538 aa)
pyrHUnannotated protein; Catalyzes the reversible phosphorylation of UMP to UDP. (249 aa)
BLEM_2094Unannotated protein. (399 aa)
tmkUnannotated protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (225 aa)
BLEM_1152Unannotated protein; Belongs to the formate--tetrahydrofolate ligase family. (505 aa)
BLEM_1134Unannotated protein. (404 aa)
BLEM_0831Unannotated protein. (480 aa)
BLEM_0865Unannotated protein; Belongs to the 5'-nucleotidase family. (701 aa)
gmkUnannotated protein; Essential for recycling GMP and indirectly, cGMP. (216 aa)
BLEM_0813Unannotated protein. (356 aa)
carBUnannotated protein. (1127 aa)
carAUnannotated protein; Belongs to the CarA family. (398 aa)
purTUnannotated protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (466 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (250 aa)
BLEM_0783Unannotated protein. (1245 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (510 aa)
purMUnannotated protein. (344 aa)
purDUnannotated protein; Belongs to the GARS family. (420 aa)
purKUnannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa)
coaXUnannotated protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (254 aa)
pyrGUnannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (553 aa)
xptUnannotated protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (192 aa)
BLEM_1923Unannotated protein. (450 aa)
BLEM_1969Unannotated protein. (429 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
uppUnannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (215 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (231 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate. (315 aa)
BLEM_2028Unannotated protein. (280 aa)
pyrFUnannotated protein; Belongs to the OMP decarboxylase family. Type 2 subfamily. (319 aa)
BLEM_2026Unannotated protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (493 aa)
BLEM_2025Unannotated protein. (139 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa)
BLEM_1772Unannotated protein. (280 aa)
Your Current Organism:
Bifidobacterium lemurum
NCBI taxonomy Id: 1603886
Other names: B. lemurum, Bifidobacterium lemurum Modesto et al. 2015, Bifidobacterium sp. LMC 13, DSM 28807, JCM 30168, strain LMC 13
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