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| | ALG83056.1 | Alanine-glyoxylate transaminase. (390 aa) |
| | tnaA | Tryptophanase. (445 aa) |
| | mdhA | Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (304 aa) |
| | ALG80962.1 | glycyl-tRNA synthetase. (588 aa) |
| | ALG80968.1 | Nitrate reductase. (773 aa) |
| | ALG80977.1 | Beta-lactamase superfamily metal-dependent hydrolase. (267 aa) |
| | fadA3 | enoyl-CoA hydratase/isomerase. (153 aa) |
| | hemD | uroporphyrinogen-III synthase. (241 aa) |
| | glnA1 | Glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (445 aa) |
| | gltA1 | Glutamate synthase large subunit. (1490 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m et hylideneamino] imidazole-4-carboxamide isomerase. (245 aa) |
| | hisL | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (122 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1084 aa) |
| | hpcH1 | HpcH/HpaI aldolase. (263 aa) |
| | hisS | histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (432 aa) |
| | ALG81085.1 | Pyruvoyl-dependent arginine decarboxylase. (159 aa) |
| | metB | O-acetylhomoserine aminocarboxypropyltransferase; Methionine synthase. (434 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (424 aa) |
| | ALG81112.1 | Electron transfer flavoprotein subunit alpha. (318 aa) |
| | argS | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (586 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (310 aa) |
| | ilvA | Threonine dehydratase. (403 aa) |
| | leuC1 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | leuD1 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (195 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (880 aa) |
| | gndA | 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. (298 aa) |
| | hpcH2 | 2-dehydro-3-deoxyglucarate aldolase. (259 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (497 aa) |
| | cobD1 | L-threonine-O-3-phosphate decarboxylase. (335 aa) |
| | ALG81213.1 | Cobalamine operon protein; Hydrolase. (219 aa) |
| | ALG81234.1 | Metallo-beta-lactamase superfamily protein. (214 aa) |
| | ALG81237.1 | Pyruvate dehydrogenase subunit beta. (333 aa) |
| | ALG81238.1 | Pyruvate dehydrogenase subunit alpha. (344 aa) |
| | thrA | Homoserine dehydrogenase. (313 aa) |
| | rimK2 | rimK family protein. (284 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase. (336 aa) |
| | trpB1 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (383 aa) |
| | argE1 | Acetylornithine deacetylase. (360 aa) |
| | acs1 | acetyl-CoA synthetase. (668 aa) |
| | acs2 | acetyl-CoA synthetase. (646 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (95 aa) |
| | cofE | F420-0--gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (253 aa) |
| | glcD | Oxidoreductase (glycolate oxidase iron-sulfur subunit). (1028 aa) |
| | mptD | Hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. (113 aa) |
| | gdhA1 | Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (502 aa) |
| | porD | Pyruvate:ferredoxin oxidoreductase, delta subunit. (97 aa) |
| | porG | Pyruvate:ferredoxin oxidoreductase, gamma subunit. (191 aa) |
| | ALG81447.1 | enoyl-CoA hydratase/isomerase. (259 aa) |
| | aspC1 | Aminotransferase class I and II. (399 aa) |
| | leuA1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (497 aa) |
| | guaAa | GMP synthase subunit A; Catalyzes the synthesis of GMP from XMP. (183 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (447 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (250 aa) |
| | trpB2 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | fba1 | Fructose-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (266 aa) |
| | hadL | Haloacid dehalogenase superfamily enzyme, subfamily IA. (222 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (386 aa) |
| | aroD | 3-dehydroquinate dehydratase I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (227 aa) |
| | pykF | Pyruvate kinase; Belongs to the pyruvate kinase family. (580 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (702 aa) |
| | gadD | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (363 aa) |
| | ppsA | Phosphoenolpyruvate synthase. (750 aa) |
| | gatB | aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (495 aa) |
| | dtdA | D-aminoacyl-tRNA deacylase; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. (430 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa) |
| | pspH1 | Phosphoserine phosphatase. (299 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (484 aa) |
| | sseA | Rhodanese domain-containing protein. (426 aa) |
| | ALG81591.1 | Molybdopterin oxidoreductase. (773 aa) |
| | folP | Dihydrofolate/dihydropteroate synthase. (808 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase DapE. (356 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (278 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase. (277 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (255 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (312 aa) |
| | hbd2 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (266 aa) |
| | aspC3 | Pyridoxal phosphate-dependent aminotransferase. (373 aa) |
| | thrC1 | Threonine synthase. (397 aa) |
| | ALG81690.1 | Putative GTPase. (469 aa) |
| | argF | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (292 aa) |
| | arcC | Carbamate kinase; Belongs to the carbamate kinase family. (304 aa) |
| | dfp | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase. (384 aa) |
| | ALG81726.1 | Hypothetical protein. (394 aa) |
| | ALG81727.1 | Hypothetical protein; Belongs to the UPF0107 family. (134 aa) |
| | ALG81774.1 | 2-oxoacid dehydrogenase E1 component subunit alpha. (378 aa) |
| | ALG81775.1 | 2-oxoacid dehydrogenase E1 component subunit beta. (326 aa) |
| | ALG81777.1 | Dihydrolipoamide S-acetyltransferase. (592 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (600 aa) |
| | guaA1 | GMP synthase - glutamine amidotransferase domainprotein. (248 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (572 aa) |
| | pdxT | Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa) |
| | pdxS | Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (302 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (271 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (385 aa) |
| | ocd | Ornithine cyclodeaminase. (333 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (469 aa) |
| | gatE | glutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (622 aa) |
| | maoC | Acyl dehydratase, maoC family protein. (149 aa) |
| | mptE | Hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (249 aa) |
| | prpD | 2-methylcitrate dehydratase. (451 aa) |
| | prpB | Methylisocitrate lyase. (292 aa) |
| | ALG82012.1 | Putative F420-dependent oxidoreductase. (342 aa) |
| | ALG82049.1 | Ornithine cyclodeaminase. (326 aa) |
| | apbA | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (301 aa) |
| | fba2 | Fructose-bisphosphate aldolase. (264 aa) |
| | aspC4 | Aspartate aminotransferase. (380 aa) |
| | gdhA2 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa) |
| | ALG82168.1 | Molybdopterin oxidoreductase. (768 aa) |
| | ALG82170.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (306 aa) |
| | cysE | Serine acetyltransferase. (224 aa) |
| | cysK | Cysteine synthase. (306 aa) |
| | cysS | cysteinyl-tRNA synthetase. (495 aa) |
| | menF | Isochorismate synthase. (455 aa) |
| | gatC | aspartyl/glutamyl-tRNA amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (92 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (270 aa) |
| | acaB | acetyl-CoA C-acyltransferase. (384 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (257 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (281 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (396 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa) |
| | gabT | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (488 aa) |
| | alaS1 | alanyl-tRNA synthetase. (395 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (270 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (585 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (399 aa) |
| | aspC5 | Aspartate aminotransferase. (388 aa) |
| | ALG82355.1 | Aminotransferase class V. (358 aa) |
| | hpaG | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase. (243 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (357 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (214 aa) |
| | ugd2 | UDP-glucose 6-dehydrogenase. (430 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic subunit. (300 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (384 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | tyrA | Prephenate dehydrogenase. (241 aa) |
| | ALG82515.1 | Chorismate mutase. (101 aa) |
| | aroK | Shikimate kinase. (285 aa) |
| | metE1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase. (331 aa) |
| | metE2 | Methionine synthase. (350 aa) |
| | ALG82541.1 | Alanine--glyoxylate aminotransferase. (392 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa) |
| | serA1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase. (343 aa) |
| | cofD | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (334 aa) |
| | accD | propionyl-CoA carboxylase, carboxyltransferase subunit. (516 aa) |
| | gcvP2 | Glycine dehydrogenase subunit 2. (474 aa) |
| | gcvP1 | Glycine dehydrogenase subunit 1. (440 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | gcvT | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (373 aa) |
| | ALG82592.1 | Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+). (784 aa) |
| | trpE1 | Anthranilate synthase, amidotransferase component. (200 aa) |
| | trpE2 | Anthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (522 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (212 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa) |
| | ALG82671.1 | HAD-superfamily hydrolase, subfamily IA, variant1. (223 aa) |
| | putA | Proline dehydrogenase. (280 aa) |
| | ALG82702.1 | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase. (241 aa) |
| | speB | Agmatinase; Belongs to the arginase family. (267 aa) |
| | leuA2 | 2-isopropylmalate synthase. (347 aa) |
| | ilvH2 | Acetolactate synthase small subunit. (191 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (347 aa) |
| | leuC2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa) |
| | leuD2 | 3-isopropylmalate dehydratase small subunit. (210 aa) |
| | leuB | 3-isopropylmalate dehydrogenase. (327 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (291 aa) |
| | ALG82735.1 | Zinc finger CDGSH-type domain-containing protein. (79 aa) |
| | pabB | Para-aminobenzoate synthetase component I. (484 aa) |
| | pabC | Aminodeoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (287 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1090 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (356 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | thrS | threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (640 aa) |
| | ALG82771.1 | Enolase superfamily enzyme related to L-alanine-DL-glutamate epimerase. (348 aa) |
| | gatD | glutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (413 aa) |
| | ALG82781.1 | Translation initiation factor IF-2 subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (321 aa) |
| | icd | Isocitrate dehydrogenase (NADP+). (422 aa) |
| | ALG82790.1 | Amidohydrolase. (510 aa) |
| | gpmI | Phosphoglycerate mutase (2,3-diphosphoglycerate-independent); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (506 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (201 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (223 aa) |
| | lysS | lysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (552 aa) |
| | ALG82851.1 | ATP-binding protein. (272 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (452 aa) |
| | ALG82860.1 | Hydroxyacylglutathione hydrolase. (203 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa) |
| | aceA | Isocitrate lyase. (347 aa) |
| | aceB | Malate synthase. (437 aa) |
| | glnA2 | Glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (461 aa) |
| | pheT | phenylalanyl-tRNA synthetase subunit beta. (572 aa) |
| | pheS | phenylalanyl-tRNA synthetase subunit alpha. (502 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). (513 aa) |
| | lpdA2 | Dihydrolipoamide dehydrogenase. (474 aa) |
| | pheA | Prephenate dehydratase. (268 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (944 aa) |
| | ocd1 | Ornithine cyclodeaminase; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (331 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (328 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | alaS2 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (923 aa) |
| | guaA2 | GMP synthase (glutamine-hydrolysing). (226 aa) |
| | ALG82990.1 | acetyl-CoA hydrolase. (487 aa) |
| | sufS | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (416 aa) |
| | ALG83030.1 | L-threonine aldolase. (340 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (411 aa) |
| | argH | Argininosuccinate lyase. (489 aa) |
| | ALG83039.1 | Lysine biosynthesis protein LysW. (54 aa) |
| | argA | Arginine biosynthesis regulator. (296 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (358 aa) |
| | argD | Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (373 aa) |
| | argE2 | Acetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (341 aa) |
| | thrC2 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (416 aa) |
| | pspH2 | Phosphoserine phosphatase. (214 aa) |
| | metA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (397 aa) |
