STRINGSTRING
hisB hisB hisA hisA hisL hisL hisE hisE hisF hisF hisC hisC hisD hisD hisH hisH hisG hisG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisBImidazoleglycerol-phosphate dehydratase. (195 aa)
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m et hylideneamino] imidazole-4-carboxamide isomerase. (245 aa)
hisLphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (122 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (95 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (270 aa)
hisCHistidinol-phosphate aminotransferase. (357 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
Your Current Organism:
Halanaeroarchaeum sulfurireducens
NCBI taxonomy Id: 1604004
Other names: H. sulfurireducens, Halanaeroarchaeum sulfurireducens Sorokin et al. 2016, Halobacteriaceae archaeon HSR2, Halobacteriaceae archaeon HSR3, Halobacteriaceae archaeon HSR4, Halobacteriaceae archaeon HSR5, Halobacteriaceae archaeon HSR7, Halobacteriaceae archaeon M27-SA2, JCM 30661, UNIQEM U935, strain HSR2
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