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| | aceF | AceF-S-acetyldihydrolipoate; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (546 aa) |
| | aceE | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (881 aa) |
| | glcB | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa) |
| | rpe | Ribulose-5-phosphate 3-epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Pentose phosphate pathway; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa) |
| | PP_0423 | Homologs of previously reported genes of unknown function. (234 aa) |
| | fdoG | Formate dehydrogenase-O major subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic. (1022 aa) |
| | fdoH | Formate dehydrogenase-O, beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (316 aa) |
| | fdoI | Formate dehydrogenase-O, gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic. (218 aa) |
| | fdhE | Formate dehydrogenase formation protein; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (318 aa) |
| | PP_0551 | MORN domain protein. (642 aa) |
| | bdhA | 2,3-butanediol dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (362 aa) |
| | acoC | Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system. (368 aa) |
| | acoB | Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit beta. (340 aa) |
| | acoA | Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha. (325 aa) |
| | PP_0556 | Acetoin catabolism protein. (351 aa) |
| | acoR | Acetoin catabolism regulatory protein. (617 aa) |
| | mdh | Putative malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (310 aa) |
| | PP_0665 | Putative glyceraldehyde-3-phosphate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Entner-Doudoroff. (472 aa) |
| | mqo-I | Malate:quinone oxidoreductase; Function of strongly homologous gene; enzyme; Energymetabolism : TCA cycle. (502 aa) |
| | yjjV | Putative hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (258 aa) |
| | cra | Catabolite repressor-activator, DNA-binding transcriptional dual regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Energymetabolism : Entner-Doudoroff. (331 aa) |
| | fruB | Phosphotransferase system, fructose-specific EI/HPr/EIIA components; Function experimentally demonstrated in the studied genus; transporter; Energymetabolism : Sugars; Belongs to the PEP-utilizing enzyme family. (950 aa) |
| | fruK | 1-phosphofructokinase monomer; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism; Belongs to the carbohydrate kinase PfkB family. (315 aa) |
| | fruA | Fructose PTS permease - IIBC component; Function of homologous gene experimentally demonstrated in an other organism; transporter; Energy metabolism. (580 aa) |
| | PP_0897 | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa) |
| | fumC-I | Fumarate hydratase (class 2); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (459 aa) |
| | ptsH | Phosphocarrier protein HPr. (90 aa) |
| | ptsN | Phosphotransferase system enzyme IIA, regulation of potassium transport; Function of homologous gene experimentally demonstrated in an other organism; regulator; Transportandbindingproteins : Carbohydrates, organic alcohols, and acids. (154 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Entner-Doudoroff; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa) |
| | edd | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa) |
| | glk | Glucokinase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Sugars; Belongs to the bacterial glucokinase family. (319 aa) |
| | hexR | DNA-binding transcriptional regulator; Involved in regulation of glucose metabolism. Transcriptional repressor of the gap-1 gene and of the edd-glk-gltR-2 and zwf-pgl-eda operons. Acts by binding directly to an inverted pseudopalindromic sequence in the promoter region. (287 aa) |
| | zwfA | Glucose 6-phosphate-1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (242 aa) |
| | eda | KHG/KDPG aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Entner-Doudoroff. (235 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (557 aa) |
| | PP_1157 | Acetolactate synthase; Belongs to the TPP enzyme family. (547 aa) |
| | mqo-II | Malate:quinone oxidoreductase; Function of strongly homologous gene; enzyme; Energymetabolism : TCA cycle. (527 aa) |
| | pykA | Pyruvate kinase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic; Belongs to the pyruvate kinase family. (484 aa) |
| | PP_1389 | Oxaloacetate decarboxylase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family. (291 aa) |
| | PP_1394 | Putative Acetolactate synthase, large subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the TPP enzyme family. (545 aa) |
| | gcd | Quinoprotein glucose dehydrogenase; Function experimentally demonstrated in the studied genus; enzyme; Energymetabolism : Sugars. (803 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (875 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa) |
| | ldhA | D-lactate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (342 aa) |
| | PP_1661 | Putative Dehydrogenase subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (752 aa) |
| | fumC-II | Fumarate hydratase (class 2); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | pgi-I | Glucose-6-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (554 aa) |
| | PP_1831 | Putative Membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (384 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (477 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (360 aa) |
| | PP_2052 | Putative bifunctional enzyme: sugar-phosphatase/mannitol-1-phosphate 5-dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energy metabolism. (707 aa) |
| | ppsA | Phosphoenolpyruvate synthetase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (791 aa) |
| | acnA-I | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Entner-Doudoroff; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (487 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (308 aa) |
| | PP_2183 | Putative Formate dehydrogenase, gamma subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (160 aa) |
| | PP_2184 | Putative Formate dehydrogenase, beta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (525 aa) |
| | PP_2185 | Putative Formate dehydrogenase, alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (960 aa) |
| | PP_2186 | Putative Formate dehydrogenase, delta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (67 aa) |
| | mmgF | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (296 aa) |
| | prpC | Methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism; Belongs to the citrate synthase family. (375 aa) |
| | acnA-II | Aconitate hydratase 1; Function of strongly homologous gene; enzyme; Energymetabolism : Anaerobic. (862 aa) |
| | prpF | Aconitate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism. (396 aa) |
| | prpD | 2-methylcitrate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism. (494 aa) |
| | acnB | Bifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic; Belongs to the aconitase/IPM isomerase family. (869 aa) |
| | PP_2575 | Homologs of previously reported genes of unknown function. (157 aa) |
| | mqo-III | Malate:quinone oxidoreductase; Function of strongly homologous gene; enzyme; Energymetabolism : TCA cycle. (539 aa) |
| | PP_3365 | Acetolactate synthase. (547 aa) |
| | ptxD | Putative phosphonate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Centralintermediarymetabolism : Phosphorus compounds; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa) |
| | kguT | 2-ketogluconate transporter, putative; Function experimentally demonstrated in the studied genus; transporter; Transportandbindingproteins : Carbohydrates, organic alcohols, and acids. (430 aa) |
| | kguK | Putative 2-ketogluconokinase; Function experimentally demonstrated in the studied genus; putative enzyme; Energy metabolism. (316 aa) |
| | kguE | Putative epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energy metabolism. (259 aa) |
| | ptxS | 2-ketogluconate utilization repressor; Function experimentally demonstrated in the studied genus; regulator; Biologicalprocesses : Control. (339 aa) |
| | PP_3415 | Transcriptional regulator, LacI family. (339 aa) |
| | gnuK | D-gluconate kinase; Function experimentally demonstrated in the studied strain; enzyme. (179 aa) |
| | PP_3443 | Putative glyceraldehyde-3-phosphate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Entner-Doudoroff. (539 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase. (339 aa) |
| | pgm | Phosphoglucomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Sugars. (545 aa) |
| | icd | Isocitrate dehydrogenase, NADP(+)-specific; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic. (418 aa) |
| | idh | Isocitrate dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the monomeric-type IDH family. (741 aa) |
| | zwfB | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (501 aa) |
| | gntZ | Putative 6-phosphogluconate dehydrogenase, decarboxylating; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (327 aa) |
| | aceA | Isocitrate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : TCA cycle. (441 aa) |
| | sucD | succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit glutaryl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | lpdG | Dihydrolipoyl dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Biosynthesisofcofactors,prostheticgroups,andcarriers : Folic acid. (478 aa) |
| | sucB | 2-oxoglutarate dehydrogenase dihydrolipoyltranssuccinylase subunit; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (407 aa) |
| | sucA | 2-oxoglutarate decarboxylase, thiamine-requiring E1 subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : TCA cycle. (943 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic. (234 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa) |
| | sdhD | Succinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (122 aa) |
| | sdhC | Succinate dehydrogenase membrane b-556 subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Aerobic. (128 aa) |
| | gltA | Citrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic; Belongs to the citrate synthase family. (429 aa) |
| | ttuD | Putative hydroxypyruvate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (424 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (471 aa) |
| | bkdAA | Branched-chain alpha-keto acid dehydrogenase complex, alpha subunit; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (410 aa) |
| | bkdAB | Branched-chain alpha-keto acid dehydrogenase complex, beta subunit; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (339 aa) |
| | bkdB | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (423 aa) |
| | lpdV | Dihydrolipoyl dehydrogenase component of branched-chain alpha-keto acid dehydrogenase complex; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (459 aa) |
| | aceK | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (571 aa) |
| | ldh | Leucine dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (339 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | ilvH | Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family. (163 aa) |
| | ilvI | Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family. (574 aa) |
| | pgi-II | Glucose-6-phosphate isomerase; Function of strongly homologous gene; enzyme. (554 aa) |
| | tpiA | Triose phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | fba | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (387 aa) |
| | tktA | Transketolase A; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | fbp | Fructose-1,6-bisphosphatase, class 1; Function of strongly homologous gene; enzyme; Energymetabolism : Glycolysis/gluconeogenesis. (336 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa) |
| | maeB | Malic enzyme B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (422 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (613 aa) |
| | ptsP | Phosphoenolpyruvate-dependent regulator (with NPR and NTR proteins); Function of homologous gene experimentally demonstrated in an other organism; regulator; Energy metabolism; Belongs to the PEP-utilizing enzyme family. (759 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (224 aa) |
| | PP_5332 | Homologs of previously reported genes of unknown function; Belongs to the glucose-6-phosphate 1-epimerase family. (298 aa) |
| | pycB | Pyruvate carboxylase subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism. (602 aa) |
| | pycA | Pyruvate carboxylase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism. (471 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (485 aa) |
| | lpd | Dihydrolipoyl dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Biosynthesisofcofactors,prostheticgroups,andcarriers : Folic acid. (466 aa) |
