(5 nodes) Iron-sulfur cluster assembly network (Pseudomonas putida KT2440)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	iscU	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
	hscB	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (173 aa)
	hscA	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (620 aa)
	fdx	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport. (113 aa)
	iscX	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization. (66 aa)

Your Current Organism:

Pseudomonas putida KT2440

NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
fdx	hscA	PP_0847	PP_0846	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport.	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.998
fdx	hscB	PP_0847	PP_0845	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport.	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	0.998
fdx	iscU	PP_0847	PP_0843	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport.	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.997
fdx	iscX	PP_0847	PP_0848	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport.	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization.	0.997
hscA	fdx	PP_0846	PP_0847	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport.	0.998
hscA	hscB	PP_0846	PP_0845	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	0.997
hscA	iscU	PP_0846	PP_0843	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.992
hscA	iscX	PP_0846	PP_0848	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization.	0.977
hscB	fdx	PP_0845	PP_0847	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport.	0.998
hscB	hscA	PP_0845	PP_0846	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.997
hscB	iscU	PP_0845	PP_0843	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.999
hscB	iscX	PP_0845	PP_0848	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization.	0.991
iscU	fdx	PP_0843	PP_0847	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport.	0.997
iscU	hscA	PP_0843	PP_0846	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.992
iscU	hscB	PP_0843	PP_0845	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	0.999
iscU	iscX	PP_0843	PP_0848	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization.	0.955
iscX	fdx	PP_0848	PP_0847	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization.	Ferredoxin; Function of homologous gene experimentally demonstrated in an other organism; carrier; Energymetabolism : Electron transport.	0.997
iscX	hscA	PP_0848	PP_0846	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization.	DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.	0.977
iscX	hscB	PP_0848	PP_0845	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization.	DnaJ-like molecular chaperone specific for IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.	0.991
iscX	iscU	PP_0848	PP_0843	Donor of Fe2+ and regulator of cysteine desulfurase activity; Function of homologous gene experimentally demonstrated in an other organism; regulator; Proteinfate : Protein folding and stabilization.	Scaffold protein involved in iron-sulfur cluster assembly; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.	0.955