STRINGSTRING
crp crp PP_0681 PP_0681 PP_0788 PP_0788 rpoN rpoN hupN hupN rsmI rsmI rpoS rpoS csrA-2 csrA-2 ihfB ihfB PP_1841 PP_1841 hupB hupB PP_2304 PP_2304 ihfA ihfA PP_3581 PP_3581 PP_3765 PP_3765 csrA-3 csrA-3 uvrY uvrY fleQ fleQ csrA csrA PP_4642 PP_4642 PP_4720 PP_4720 PP_4858 PP_4858 pde pde rsmE rsmE cyaA cyaA lrp lrp hupA hupA PP_5496 PP_5496 PP_5586 PP_5586
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
crpDNA-binding transcriptional dual regulator; Function experimentally demonstrated in the studied species; regulator; Transcription. (214 aa)
PP_0681Homologs of previously reported genes of unknown function. (112 aa)
PP_0788Homologs of previously reported genes of unknown function; Unknown function. (719 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the xylCAB operon and the xylS gene. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein XylR for the expression of the xylCAB operon and xylS. (497 aa)
hupNPutative DNA-binding protein HU, form N; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator; Belongs to the bacterial histone-like protein family. (93 aa)
rsmI16S rRNA 2'-O-ribose C1402 methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (294 aa)
rpoSRNA polymerase, sigma S (sigma 38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (335 aa)
csrA-2Putative carbon storage regulator, csrA-like; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (59 aa)
ihfBIntegration host factor subunit beta; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (100 aa)
PP_1841Cytochrome c family protein. (266 aa)
hupBDNA binding regulator, beta subunit B; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
PP_2304Putative Peptidyl-prolyl cis-trans isomerase D; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (623 aa)
ihfAIntegration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (100 aa)
PP_3581Homologs of previously reported genes of unknown function. (695 aa)
PP_3765H-NS family protein MvaT. (119 aa)
csrA-3Carbon storage regulator (csrA-like); A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (65 aa)
uvrYTwo-componenent system BarA/UvrY - regulatory subunit; Function of homologous gene experimentally demonstrated in an other organism; regulator; Transcription. (212 aa)
fleQTranscriptional regulator FleQ. (491 aa)
csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (62 aa)
PP_4642Cyclic diguanosine monophosphate-binding protein; Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein. (128 aa)
PP_4720Putative RNA binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Unknown function. (102 aa)
PP_4858Homologs of previously reported genes of unknown function. (165 aa)
pde3',5'-cyclic-nucleotide phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (266 aa)
rsmE16S rRNA m3U1498 methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (239 aa)
cyaAAdenylate cyclase; Function experimentally demonstrated in the studied strain; enzyme. (951 aa)
lrpDNA-binding transcriptional dual regulator, leucine-binding; Function of homologous gene experimentally demonstrated in an other organism; regulator; Aminoacidbiosynthesis : Pyruvate family. (162 aa)
hupADNA-binding protein HU-alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (99 aa)
PP_5496Homologs of previously reported genes of unknown function. (58 aa)
PP_5586Exported protein of unknown function; No homology to any previously reported sequences; Unknown function. (58 aa)
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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