STRINGSTRING
PP_0163 PP_0163 PP_0620 PP_0620 PP_0968 PP_0968 PP_0969 PP_0969 PP_0970 PP_0970 PP_0971 PP_0971 PP_0972 PP_0972 PP_1255 PP_1255 PP_1256 PP_1256 PP_1257 PP_1257 prpA prpA PP_1265 PP_1265 pcaR pcaR pcaK pcaK pcaF-I pcaF-I pcaB pcaB pcaD pcaD pcaC pcaC pcaP pcaP truD truD pcm pcm PP_1697 PP_1697 PP_1698 PP_1698 PP_1699 PP_1699 PP_1707 PP_1707 PP_1708 PP_1708 PP_1710 PP_1710 PP_1712 PP_1712 pcaQ pcaQ PP_1820 PP_1820 PP_1876 PP_1876 ybhD ybhD PP_2055 PP_2055 yraO yraO PP_2058 PP_2058 PP_2066 PP_2066 PP_2252 PP_2252 PP_2253 PP_2253 PP_2254 PP_2254 PP_2256 PP_2256 PP_2333 PP_2333 gllD gllD gllC gllC gllB gllB gllR gllR glllA glllA quiC quiC PP_2585 PP_2585 PP_2600 PP_2600 ligC ligC PP_2603 PP_2603 PP_2605 PP_2605 PP_2606 PP_2606 PP_2607 PP_2607 PP_2608 PP_2608 PP_2609 PP_2609 PP_2662 PP_2662 PP_2830 PP_2830 fucD fucD PP_2834 PP_2834 PP_2835 PP_2835 PP_2836 PP_2836 PP_2837 PP_2837 PP_2838 PP_2838 PP_2839 PP_2839 benA benA benB benB benC benC benD benD benK benK catA-II catA-II benE-II benE-II nicP-I nicP-I PP_3180 PP_3180 mhpT mhpT fcs fcs vdh vdh PP_3358 PP_3358 PP_3359 PP_3359 PP_3527 PP_3527 pobA pobA pobR pobR PP_3588 PP_3588 kdgD kdgD gudP gudP garD garD PP_3602 PP_3602 PP_3648 PP_3648 catA-I catA-I catC catC catB catB catR catR vanA vanA vanB vanB PP_3738 PP_3738 galP-IV galP-IV PP_3740 PP_3740 pcaI pcaI pcaJ pcaJ ligA ligA PP_4277 PP_4277 PP_4283 PP_4283 PP_4345 PP_4345 PP_4461 PP_4461 PP_4462 PP_4462 PP_4463 PP_4463 PP_4578 PP_4578 pcaG pcaG pcaH pcaH pdhR pdhR gudD gudD PP_4758 PP_4758 PP_4759 PP_4759 ligB ligB rnk rnk PP_5224 PP_5224 PP_5226 PP_5226 PP_5229 PP_5229 xerC xerC PP_5654 PP_5654
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PP_0163Putative transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (229 aa)
PP_0620GntR family transcriptional regulator. (254 aa)
PP_0968Homologs of previously reported genes of unknown function. (413 aa)
PP_0969Transcriptional regulator, GntR family. (216 aa)
PP_0970Cyanate MFS transporter. (434 aa)
PP_0971Homologs of previously reported genes of unknown function. (158 aa)
PP_0972UPF0213 protein PP_0972; Belongs to the UPF0213 family. (105 aa)
PP_1255Putative cis-4-hydroxy-D-proline oxidase; No homology to any previously reported sequences; putative enzyme; Energymetabolism : Amino acids and amines. (415 aa)
PP_1256Putative alpha-ketoglutarate semialdehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Amino acids and amines. (525 aa)
PP_1257Putative 1-pyrroline-4-hydroxy-2-carboxylate deaminase; No homology to any previously reported sequences; putative enzyme; Energymetabolism : Amino acids and amines; Belongs to the DapA family. (315 aa)
prpA4-hydroxyproline epimerase; Catalyzes the reversible epimerization of cis-4-hydroxy-D- proline (c4DHyp) to trans-4-hydroxy-L-proline (t4LHyp). May be involved in a degradation pathway that allows P.putida strain KT2440 to grow on either epimer of 4-hydroxyproline, c4DHyp and t4LHyp, as the sole carbon and nitrogen source. Does not exhibit measureable racemase activity in vitro with any of the 19 natural chiral amino acid enantiomers. (308 aa)
PP_1265Homologs of previously reported genes of unknown function. (66 aa)
pcaRTranscription regulatory protein (pca regulon); Function experimentally demonstrated in the studied species; regulator; Energy metabolism. (291 aa)
pcaK4-hydroxybenzoate transporter; Function experimentally demonstrated in the studied species; transporter; Transport and binding proteins. (448 aa)
pcaF-Ibeta-ketoadipyl-CoA thiolase; Function experimentally demonstrated in the studied strain; enzyme; Energy metabolism; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
pcaB3-carboxy-cis,cis-muconate cycloisomerase; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (450 aa)
pcaD3-oxoadipate enol-lactonase 2; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (263 aa)
pcaC4-carboxymuconolactone decarboxylase; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (130 aa)
pcaPPutative porin-encoding gene; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (174 aa)
truDtRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (352 aa)
pcmProtein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (231 aa)
PP_1697Transcriptional regulator, GntR family; Function of strongly homologous gene; regulator; Transcription. (243 aa)
PP_1698Major facilitator family transporter. (424 aa)
PP_16992-pyrone-4,6-dicarboxylic acid hydrolase; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (280 aa)
PP_1707D-isomer specific 2-hydroxyacid dehydrogenase family protein. (316 aa)
PP_1708Oxidoreductase, short chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (252 aa)
PP_1710MFS transporter, phthalate permease family. (446 aa)
PP_1712Homologs of previously reported genes of unknown function. (469 aa)
pcaQTranscriptional regulator PcaQ; Belongs to the LysR transcriptional regulatory family. (310 aa)
PP_1820Benzoate transport protein. (398 aa)
PP_1876Putative ATP/GTP-binding protein of the AAA+ family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (295 aa)
ybhDPutative DNA-binding transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Transcription; Belongs to the LysR transcriptional regulatory family. (297 aa)
PP_2055Putative isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (359 aa)
yraOUncharacterized transporter YraO. (434 aa)
PP_2058Putative Porin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (417 aa)
PP_2066Transcriptional regulator, GntR family. (254 aa)
PP_2252Homologs of previously reported genes of unknown function. (349 aa)
PP_2253Transcriptional regulator, GntR family. (222 aa)
PP_2254Transcriptional regulator, GntR family. (232 aa)
PP_2256Transcriptional regulator, Cro/CI family. (104 aa)
PP_2333GntR family transcriptional regulator. (238 aa)
gllD4-oxalomesaconate tautomerase; Catalyzes the tautomerization of the 4-oxalomesaconic acid keto (OMAketo) generated by GalA dioxygenase to 4-oxalomesaconic acid enol (OMAenol). Mediates the second step in gallate degradation pathway. (361 aa)
gllC4-carboxy-4-hydroxy-2-oxoadipic acid aldolase; Catalyzes the conversion of 4-carboxy-4-hydroxy-2-oxoadipic acid (CHA) to pyruvate and oxaloacetate, the last step of gallate degradation pathway; Belongs to the LigK/PcmE family. (238 aa)
gllB4-oxalmesaconate hydratase; Catalyzes the conversion of oxalomesaconic acid enol (OMAenol) to 4-carboxy-4-hydroxy-2-oxoadipic acid (CHA). Mediates the third step of gallate degradation pathway. (258 aa)
gllRHTH-type transcriptional regulator GalR; Transcriptional regulator for the galBCD and galTAP operons, encoding genes of the gallate degradation pathway. (397 aa)
glllAGallate dioxygenase; Ring-cleavage dioxygenase that acts specifically on gallate to produce the keto-tautomer of 4-oxalomesaconate. Mediates the first step of gallate degradation pathway. (420 aa)
quiCPutative 3-dehydroshikimate dehydratase; Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. (635 aa)
PP_2585Alpha-ketoglutaric semialdehyde dehydrogenase. (526 aa)
PP_2600Homologs of previously reported genes of unknown function. (570 aa)
ligCPutative 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biologicalprocesses : Scavenge (Catabolism). (350 aa)
PP_2603Homologs of previously reported genes of unknown function. (271 aa)
PP_2605Homologs of previously reported genes of unknown function. (562 aa)
PP_2606Homologs of previously reported genes of unknown function. (106 aa)
PP_2607Homologs of previously reported genes of unknown function. (577 aa)
PP_2608Shikimate dehydrogenase family protein. (269 aa)
PP_2609Transcriptional regulator, IclR family. (256 aa)
PP_2662Homologs of previously reported genes of unknown function. (395 aa)
PP_2830Major facilitator family transporter. (450 aa)
fucDL-fuconate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Pentose phosphate pathway; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (411 aa)
PP_2834Putative D-galactarate dehydratase/Altronate dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Sugars. (513 aa)
PP_2835Putative oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Biologicalprocesses : Scavenge (Catabolism); Belongs to the LDH2/MDH2 oxidoreductase family. (344 aa)
PP_2836Putative 2-keto-3-deoxyxylonate dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Sugars. (405 aa)
PP_2837Putative uronate transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (436 aa)
PP_2838Conserved protein of unknown function; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (549 aa)
PP_2839Homologs of previously reported genes of unknown function. (762 aa)
benABenzoate 1,2-dioxygenase subunit alpha; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism. (452 aa)
benBBenzoate 1,2-dioxygenase subunit beta; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism. (161 aa)
benCBenzoate 1,2-dioxygenase electron transfer component; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism. (336 aa)
benD1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (253 aa)
benKBenzoate MFS transporter; Function of strongly homologous gene; transporter; Energy metabolism. (442 aa)
catA-IICatechol 1,2-dioxygenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism. (304 aa)
benE-IIBenzoate transport protein; Function of strongly homologous gene; transporter; Energy metabolism. (423 aa)
nicP-IPorin-like protein; Function experimentally demonstrated in the studied strain; transporter. (416 aa)
PP_3180Smp-30/Cgr1 family protein. (346 aa)
mhpT3-hydroxyphenylpropionate / 3-hydroxycinnamate:H+ symporter; Function of strongly homologous gene; transporter; Fattyacidandphospholipidmetabolism : Degradation. (413 aa)
fcsferuloyl-CoA-synthetase; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (627 aa)
vdhVanillin dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism); Belongs to the aldehyde dehydrogenase family. (482 aa)
PP_3358hydroxycinnamoyl-CoA hydratase-lyase; Function of strongly homologous gene; enzyme; Biologicalprocesses : Scavenge (Catabolism); Belongs to the enoyl-CoA hydratase/isomerase family. (276 aa)
PP_3359Putative Hydroxycinnamic acid degradation regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (156 aa)
PP_3527Transcriptional regulator, TetR family. (227 aa)
pobAP-hydroxybenzoate hydroxylase; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (395 aa)
pobRTranscriptional regulator; Function experimentally demonstrated in the studied species; regulator; Energy metabolism. (292 aa)
PP_3588Multidrug resistance transporter, Bcr/CflA family. (395 aa)
kdgD5-dehydro-4-deoxyglucarate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the DapA family. (303 aa)
gudPGlucarate transporter; Function of homologous gene experimentally demonstrated in an other organism; transporter; Energy metabolism. (454 aa)
garDGalactarate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (517 aa)
PP_36022,5-dioxovalerate dehydrogenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism. (526 aa)
PP_3648Carboxymuconolactone decarboxylase family protein. (129 aa)
catA-ICatechol 1,2-dioxygenase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism. (311 aa)
catCMuconolactone Delta-isomerase; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism; Belongs to the muconolactone Delta-isomerase family. (96 aa)
catBMuconate cycloisomerase 1; Function experimentally demonstrated in the studied species; enzyme; Energy metabolism; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (373 aa)
catRHTH-type transcriptional regulator; Function experimentally demonstrated in the studied species; regulator; Energy metabolism; Belongs to the LysR transcriptional regulatory family. (290 aa)
vanAVanillate O-demethylase oxygenase subunit; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (355 aa)
vanBVanillate O-demethylase oxidoreductase; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (316 aa)
PP_3738Putative Transcriptional regulator VanR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (237 aa)
galP-IVPorin-like protein; Function experimentally demonstrated in the studied strain; transporter. (417 aa)
PP_3740Major facilitator family transporter. (446 aa)
pcaI3-oxoadipate CoA-transferase subunit A; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (231 aa)
pcaJ3-oxoadipate CoA-transferase subunit A; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (213 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (776 aa)
PP_4277Transcriptional regulator, GntR family. (219 aa)
PP_4283Transcriptional regulator, GntR family. (251 aa)
PP_4345Transcriptional regulator, GntR family. (230 aa)
PP_4461Major facilitator family transporter. (430 aa)
PP_4462Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (221 aa)
PP_4463Carbon-nitrogen hydrolase family protein. (273 aa)
PP_4578Major facilitator family transporter. (428 aa)
pcaGProtocatechuate 3,4-dioxygenase alpha chain; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (201 aa)
pcaHProtocatechuate 3,4-dioxygenase beta chain; Function experimentally demonstrated in the studied species; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (239 aa)
pdhRDNA-binding transcriptional dual regulator, LldR-L-lactate; Function experimentally demonstrated in the studied genus; regulator; Energymetabolism : Aerobic. (255 aa)
gudDD-glucarate dehydratase / L-idarate epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (448 aa)
PP_4758Major facilitator family transporter. (455 aa)
PP_4759Transcriptional regulator, GntR family; Function of strongly homologous gene; regulator; Regulatory functions. (233 aa)
ligBDNA ligase B; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. (566 aa)
rnkRegulator of nucleotide diphosphokinase; Function of homologous gene experimentally demonstrated in an other organism; regulator. (136 aa)
PP_5224Homologs of previously reported genes of unknown function. (74 aa)
PP_5226Lipoprotein, Lppl family. (72 aa)
PP_5229Homologs of previously reported genes of unknown function; Unknown function. (236 aa)
xerCTyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (299 aa)
PP_5654Putative phosphotriesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (138 aa)
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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