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fabA fabA ilvD ilvD mutM mutM aroB aroB hutU hutU nnrD nnrD gudD gudD fpr-II fpr-II PP_4552 PP_4552 trpA trpA trpB trpB cynT cynT hemD hemD hisB hisB aroQ-I aroQ-I PP_0662 PP_0662 PP_0897 PP_0897 fumC-I fumC-I edd edd mltF mltF nth nth dapA-I dapA-I algL algL thrC thrC tcdA tcdA fabZ fabZ eno eno fumC-II fumC-II pheA pheA rffG rffG gmd gmd rmd rmd aroC aroC PP_1884 PP_1884 PP_1885 PP_1885 PP_1886 PP_1886 leuC leuC leuD leuD PP_2036 PP_2036 acnA-I acnA-I fadB fadB PP_2170 PP_2170 acnA-II acnA-II prpD prpD acnB acnB queD queD aroQ-II aroQ-II PP_2491 PP_2491 gllB gllB quiC quiC dapA-II dapA-II PP_2652 PP_2652 hemB hemB PP_2992 PP_2992 aroQ-III aroQ-III hemBB hemBB PP_3358 PP_3358 PP_3431 PP_3431 kdgD kdgD PP_3733 PP_3733 phhB phhB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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fabA3R-3-hydroxydecanoyl acyl carrier protein (ACP) dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (171 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (613 aa)
mutMFormamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (270 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (365 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (557 aa)
nnrDADP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (286 aa)
gudDD-glucarate dehydratase / L-idarate epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (448 aa)
fpr-IIferredoxin--NADP(+) reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Central intermediary metabolism. (258 aa)
PP_4552Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (156 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa)
cynTCarbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (239 aa)
hemDUroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (255 aa)
hisBImidazoleglycerol-phosphate dehydratase. (210 aa)
aroQ-I3-dehydroquinate dehydratase 1, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
PP_0662Putative Threonine synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (462 aa)
PP_0897Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
fumC-IFumarate hydratase (class 2); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (459 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa)
mltFMembrane-bound lytic murein transglycosylase F; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family. (485 aa)
nthDNA glycosylase/apyrimidinic (AP) lyase specific for damaged pyrimidinic sites; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)
dapA-I4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
algLAlginate lyase; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the periplasmic space. (371 aa)
thrCThreonine synthase. (469 aa)
tcdAtRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Proteinsynthesis : tRNA and rRNA base modification. (271 aa)
fabZ3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (163 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa)
fumC-IIFumarate hydratase (class 2); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
pheAChorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme. (367 aa)
rffGdTDP-glucose 4,6-dehydratase 2; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (366 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (355 aa)
rmdOxidoreductase Rmd. (298 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa)
PP_1884Homologs of previously reported genes of unknown function. (821 aa)
PP_1885Homologs of previously reported genes of unknown function. (784 aa)
PP_1886Homologs of previously reported genes of unknown function. (975 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (477 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa)
PP_2036Putative 4-hydroxy-tetrahydrodipicolinate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Aminoacidbiosynthesis : Aspartate family; Belongs to the DapA family. (295 aa)
acnA-IAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa)
fadBenoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (715 aa)
PP_2170Putative enzyme, chorismate mutase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (232 aa)
acnA-IIAconitate hydratase 1; Function of strongly homologous gene; enzyme; Energymetabolism : Anaerobic. (862 aa)
prpD2-methylcitrate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism. (494 aa)
acnBBifunctional aconitate hydratase 2 and 2-methylisocitrate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Anaerobic; Belongs to the aconitase/IPM isomerase family. (869 aa)
queD6-carboxy-5,6,7,8-tetrahydropterin synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (118 aa)
aroQ-II3-dehydroquinate dehydratase 2, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
PP_2491ThiJ/PfpI family protein. (225 aa)
gllB4-oxalmesaconate hydratase; Catalyzes the conversion of oxalomesaconic acid enol (OMAenol) to 4-carboxy-4-hydroxy-2-oxoadipic acid (CHA). Mediates the third step of gallate degradation pathway. (258 aa)
quiCPutative 3-dehydroshikimate dehydratase; Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways. (635 aa)
dapA-II4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (288 aa)
PP_2652Putative Hydratase/decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (261 aa)
hemB5-aminolevulinate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesisofcofactors,prostheticgroups,andcarriers : Heme, porphyrin, and cobalamin; Belongs to the ALAD family. (324 aa)
PP_2992Homologs of previously reported genes of unknown function. (267 aa)
aroQ-III3-dehydroquinate dehydratase 3, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa)
hemBBPorphobilinogen synthase (delta-aminolevulinic acid dehydratase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. (333 aa)
PP_3358hydroxycinnamoyl-CoA hydratase-lyase; Function of strongly homologous gene; enzyme; Biologicalprocesses : Scavenge (Catabolism); Belongs to the enoyl-CoA hydratase/isomerase family. (276 aa)
PP_3431ThiJ/PfpI family protein. (228 aa)
kdgD5-dehydro-4-deoxyglucarate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Fattyacidandphospholipidmetabolism : Degradation; Belongs to the DapA family. (303 aa)
PP_3733Putative ABC transporter lipoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (352 aa)
phhBPterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. (118 aa)
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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