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| | metH | Cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1235 aa) |
| | PP_5342 | Transcriptional regulator, GntR family. (509 aa) |
| | yjiR | Putative regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Transcription. (496 aa) |
| | dadX | Alanine racemase, PLP-binding; Isomerizes L-alanine to D-alanine which is then likely oxidized to pyruvate by DadA. Shows racemase activity with both alanine stereoisomers, negligible activity with D-cysteine and L-serine, and exhibits no activity with the remaining natural chiral amino acids. (357 aa) |
| | lysA-II | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa) |
| | spuC-II | Polyamine:pyruvate transaminase; Function experimentally demonstrated in the studied genus; enzyme; Central intermediary metabolism; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa) |
| | PP_5159 | Homologs of previously reported genes of unknown function. (207 aa) |
| | ilvA-II | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa) |
| | PP_5094 | Putative enzyme with PLP binding domain; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (228 aa) |
| | glgP | Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (816 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (468 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase. (427 aa) |
| | PP_4692 | Putative aspartate/tyrosine/aromatic aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (390 aa) |
| | ilvI | Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family. (574 aa) |
| | PP_4594 | Putative Cystathionine gamma-synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (393 aa) |
| | astC | Succinylornithine transaminase/acetylornithine aminotransferase; Function experimentally demonstrated in the studied genus; enzyme; Aminoacidbiosynthesis : Glutamate family; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa) |
| | PP_4430 | Putative threonine dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (330 aa) |
| | PP_4429 | Transcriptional regulator, GntR family. (466 aa) |
| | PP_4421 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (463 aa) |
| | PP_4350 | Aminotransferase, class V, NifS/IscS family. (387 aa) |
| | PP_4348 | Putative Cystathionine beta-lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (364 aa) |
| | gcl | Glyoxylate carboligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energy metabolism; Belongs to the TPP enzyme family. (591 aa) |
| | pvdL | Non-ribosomal peptide synthase (subunit of ferribactin synthase); Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Biosynthesis. (4317 aa) |
| | pvdH | Diaminobutyrate-2-oxoglutarate transaminase; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Biosynthesis; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa) |
| | pvdD | Non-ribosomal peptide synthetase; Function experimentally demonstrated in the studied genus; enzyme; Fattyacidandphospholipidmetabolism : Biosynthesis. (3470 aa) |
| | PP_4197 | Transcriptional regulator, GntR family. (530 aa) |
| | sucA | 2-oxoglutarate decarboxylase, thiamine-requiring E1 subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : TCA cycle. (943 aa) |
| | PP_4154 | Putative class 3 aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (976 aa) |
| | PP_4108 | Putative 4-aminobutyrate aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa) |
| | PP_3788 | Putative Non-ribosomal peptide synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the ATP-dependent AMP-binding enzyme family. (517 aa) |
| | aspC | Aminotransferase; Function experimentally demonstrated in the studied species; enzyme; Biologicalprocesses : Scavenge (Catabolism). (402 aa) |
| | PP_3750 | Transcriptional regulator, GntR family. (477 aa) |
| | aruI | Putative 2-ketoarginine decarboxylase AruI; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the TPP enzyme family. (535 aa) |
| | alr | Alanine racemase; Amino-acid racemase able to utilize a broad range of substrates. Reversibly racemizes 9 of the 19 natural chiral amino acids known, including both positively charged amino acids (Lys, Arg and His) and non-beta-branched aliphatic amino acids (Ala, Leu, Met, Ser, Gln and Asn). Among these amino acids, activity is the highest with lysine and arginine, and poor or very poor with the others. Plays a primary role in the catabolism of basic amino acid, that allows P.putida strain KT2440 to grow on L-Lys and L-Arg as the sole source of carbon and nitrogen, through conversion [...] (409 aa) |
| | aruH | Arginine--pyruvate transaminase AruH. (396 aa) |
| | PP_3718 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (470 aa) |
| | amaC | D-lysine aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aromatic amino acid family. (398 aa) |
| | PP_3544 | Transcriptional regulator, GntR family. (469 aa) |
| | PP_3365 | Acetolactate synthase. (547 aa) |
| | PP_3361 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (1015 aa) |
| | PP_3191 | Putative threonine ammonia-lyase / dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energymetabolism : Amino acids and amines. (350 aa) |
| | PP_2948 | Transcriptional regulator, GntR family. (460 aa) |
| | PP_2930 | Putative L-serine dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (305 aa) |
| | PP_2829 | Transcriptional regulator, GntR family. (452 aa) |
| | PP_2800 | Putative Diaminobutyrate-2-oxoglutarate transaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (417 aa) |
| | PP_2799 | Aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa) |
| | PP_2642 | Transcriptional regulator, GntR family. (496 aa) |
| | PP_2588 | Aminotransferase, class III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (460 aa) |
| | PP_2552 | DOPA decarboxylase. (470 aa) |
| | PP_2542 | Transcriptional regulator, GntR family. (474 aa) |
| | PP_2528 | O-acetylhomoserine (thiol)-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (425 aa) |
| | iscS-II | Cysteine desulfurase; Function of strongly homologous gene; enzyme. (405 aa) |
| | spuC-I | Polyamine:pyruvate transaminase; Function experimentally demonstrated in the studied genus; enzyme; Central intermediary metabolism; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa) |
| | PP_2129 | Homologs of previously reported genes of unknown function. (267 aa) |
| | lysA-I | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (410 aa) |
| | PP_2009 | Putative 1-aminocyclopropane-1-carboxylate deaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (297 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (403 aa) |
| | tyrB | Aromatic-amino-acid aminotransferase; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Aspartate family. (398 aa) |
| | pabC | 4-amino-4-deoxychorismate lyase; Function experimentally demonstrated in the studied genus; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. (271 aa) |
| | alaA | Glutamate-pyruvate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (403 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | cobC | Subunit of adenosylcobinamide-phosphate synthase beta component; Function experimentally demonstrated in the studied genus; enzyme; Biosynthesis of cofactors, prosthetic groups, and carriers. (330 aa) |
| | dapC | N-succinyl-L,L-diaminopimelate aminotransferase alternative; Function of strongly homologous gene; enzyme; Aminoacidbiosynthesis : Aspartate family. (398 aa) |
| | csdA | Probable cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (401 aa) |
| | thrC | Threonine synthase. (469 aa) |
| | PP_1423 | Homologs of previously reported genes of unknown function; Belongs to the GcvT family. (313 aa) |
| | PP_1394 | Putative Acetolactate synthase, large subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the TPP enzyme family. (545 aa) |
| | mdeA | Methionine gamma-lyase; Function experimentally demonstrated in the studied strain; enzyme; Fattyacidandphospholipidmetabolism : Degradation. (398 aa) |
| | PP_1157 | Acetolactate synthase; Belongs to the TPP enzyme family. (547 aa) |
| | PP_1109 | Transcriptional regulator, GntR family. (446 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (348 aa) |
| | PP_0862 | PKHD-type hydroxylase PP_0862. (226 aa) |
| | PP_0858 | Putative methionine/glutamine aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (382 aa) |
| | iscS-I | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (404 aa) |
| | alaC | Aminotransferase; Function of strongly homologous gene; enzyme; Regulatory functions. (402 aa) |
| | glyA-II | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | PP_0662 | Putative Threonine synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (462 aa) |
| | metB | Cystathionine gamma-synthase. (423 aa) |
| | PP_0596 | Omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa) |
| | eutC | Ethanolamine ammonia-lyase, beta-subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Amino acids and amines; Belongs to the EutC family. (272 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa) |
| | PP_0524 | Putative Periplasmic cobalamin-binding protein HutB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (270 aa) |
| | PP_0486 | Transcriptional regulator, GntR family. (474 aa) |
| | aruC | Acetylornithine aminotransferase 2; Function experimentally demonstrated in the studied strain; enzyme; Aminoacidbiosynthesis : Glutamate family; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (390 aa) |
| | glyA-I | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | gabT | 4-aminobutyrate aminotransferase; Catalyzes the conversion of 5-aminovalerate to 5- oxopentanoate. (425 aa) |
