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bcsA bcsA bcsG bcsG yijP yijP PP_2377 PP_2377 PP_2124 PP_2124 kdsB kdsB PP_1838 PP_1838 rffE rffE kdsA-II kdsA-II PP_1806 PP_1806 wbpM wbpM wbpL wbpL wbpV wbpV wbpZ wbpZ wbpY wbpY gmd gmd PP_1793 PP_1793 PP_1792 PP_1792 PP_1790 PP_1790 PP_1788 PP_1788 PP_1786 PP_1786 rffG rffG rfbD rfbD rfbA rfbA rfbC rfbC PP_1781 PP_1781 cpsG cpsG PP_1776 PP_1776 PP_1740 PP_1740 htrB htrB PP_1690 PP_1690 PP_1627 PP_1627 kdsA-I kdsA-I PP_1526 PP_1526 mucB mucB mucA mucA rpoE rpoE PP_1370 PP_1370 algD algD alg8 alg8 alg44 alg44 algK algK algE algE algG algG algX algX algI algI algJ algJ algF algF algA algA glmP glmP kdsD kdsD kdsC kdsC PP_0899 PP_0899 PP_0778 PP_0778 PP_0345 PP_0345 waaP waaP waaG waaG waaC waaC waaF waaF rmlC rmlC PP_0251 PP_0251 algP algP algQ algQ algB algB gmhB gmhB PP_0034 PP_0034 PP_0033 PP_0033 PP_0024 PP_0024 PP_1033 PP_1033 algC algC opgG opgG opgH opgH PP_4978 PP_4978 PP_4943 PP_4943 PP_4942 PP_4942 PP_4940 PP_4940 PP_4938 PP_4938 wzy wzy waaA waaA PP_4592 PP_4592 glgE glgE glgB glgB glgA glgA galU galU PP_3142 PP_3142 PP_3141 PP_3141 PP_3140 PP_3140 PP_3139 PP_3139 PP_3137 PP_3137 PP_3135 PP_3135 PP_3132 PP_3132 PP_3128 PP_3128 PP_3127 PP_3127 PP_3126 PP_3126 PP_3016 PP_3016 PP_2974 PP_2974 udg udg PP_2852 PP_2852 bcsB bcsB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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bcsACellulose synthase and translocator subunit; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose. (869 aa)
bcsGPutative endoglucanase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Cellenvelope : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides. (537 aa)
yijPPutative phosphoethanolamine transferase CptA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (584 aa)
PP_2377Putative acetyltransferase Act; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (344 aa)
PP_2124Putative Glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (415 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (254 aa)
PP_1838Homologs of previously reported genes of unknown function. (685 aa)
rffEUDP-N-acetylglucosamine-2-epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (380 aa)
kdsA-II2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of murein sacculus and peptidoglycan; Belongs to the KdsA family. (280 aa)
PP_1806Putative arabinose 5-phosphate isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (317 aa)
wbpMPolysaccharide biosynthesis protein. (688 aa)
wbpLGlycosyl transferase WbpL. (334 aa)
wbpVUDP-sugar epimerase. (323 aa)
wbpZGlycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (369 aa)
wbpYGlycosyl transferase WbpY. (380 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (355 aa)
PP_1793Glycosyl transferase, group 2 family protein. (862 aa)
PP_1792Glycosyl transferase, group 2 family protein. (809 aa)
PP_1790Putative Acylneuraminate cytidylyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (231 aa)
PP_1788Homologs of previously reported genes of unknown function. (359 aa)
PP_1786Putative Glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (1147 aa)
rffGdTDP-glucose 4,6-dehydratase 2; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (366 aa)
rfbDdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (300 aa)
rfbAdTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa)
rfbCdTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa)
PP_1781Putative O-acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (362 aa)
cpsGPhosphomannomutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Sugars. (453 aa)
PP_1776Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (480 aa)
PP_1740Putative Beta (1-6) glucans synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (525 aa)
htrBLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (311 aa)
PP_1690Homologs of previously reported genes of unknown function. (160 aa)
PP_1627Homologs of previously reported genes of unknown function. (363 aa)
kdsA-I2-dehydro-3-deoxyphosphooctonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of murein sacculus and peptidoglycan; Belongs to the KdsA family. (281 aa)
PP_1526Putative Beta-(1-3)-glucosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (863 aa)
mucBSigma factor AlgU regulatory protein MucB. (321 aa)
mucASigma factor AlgU negative regulatory protein. (196 aa)
rpoERNA polymerase sigma E factor; Function of homologous gene experimentally demonstrated in an other organism; factor; Transcription; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa)
PP_1370Glycosyl transferase, group 1 family protein. (373 aa)
algDGDP-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics (By similarity). (438 aa)
alg8Glycosyltransferase alg8; Possibly a processive enzyme that polymerizes GDP-mannuronic acid. (496 aa)
alg44Alginate biosynthesis protein Alg44; Required for alginate biosynthesis. (388 aa)
algKAlginate biosynthesis protein AlgK; May be involved in the polymerization of mannuronate to alginate. (484 aa)
algEAlginate production protein AlgE; Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore. (492 aa)
algGpoly(beta-D-mannuronate) C5 epimerase; Catalyzes the epimerization of beta-D-mannuronate to alpha-L- guluronate during the synthesis of the linear polysaccharide alginate. In addition, is part of a periplasmic protein complex that protects alginate from degradation by AlgL by channeling the newly formed alginate polymer through a scaffold that transfers the alginate polymer through the periplasmic space to the outer membrane secretin AlgE. (519 aa)
algXAlginate biosynthesis protein AlgX; Plays two roles in the biosynthesis of the exopolysaccharide alginate: protects alginate from degradation as the polymer traverses the periplasm, and also plays a role in its O-acetylation. Probably has acetyltransferase activity in vivo (By similarity). (479 aa)
algIProbable alginate O-acetylase AlgI; Together with AlgJ and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases the ability of alginate to act as a defense barrier (By similarity). (485 aa)
algJProbable alginate O-acetylase AlgJ; Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases the ability of alginate to act as a defense barrier (By similarity). (388 aa)
algFAlginate biosynthesis protein AlgF; Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases the ability of alginate to act as a defense barrier (By similarity). (215 aa)
algAMannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics (By similarity). (485 aa)
glmPMembrane protein required for efficient alginate biosynthesis; Function of strongly homologous gene; Unknown function. (111 aa)
kdsDD-arabinose 5-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides. (324 aa)
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (174 aa)
PP_0899Putative Ferredoxin reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (306 aa)
PP_0778Glycosyl transferase, group 1 family protein. (396 aa)
PP_0345Putative Heptose kinase WapP; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (244 aa)
waaPLipopolysaccharide core heptose (I) kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (268 aa)
waaGLipopolysaccharide glucosyltransferase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides. (374 aa)
waaCADP-heptose:LPS heptosyltransferase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides. (352 aa)
waaFADP-heptose:LPS heptosyltransferase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Cellenvelope : Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides. (349 aa)
rmlCdTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa)
PP_0251Homologs of previously reported genes of unknown function. (264 aa)
algPTranscriptional regulatory protein AlgP. (329 aa)
algQTranscriptional regulatory protein AlgQ; Belongs to the Rsd/AlgQ family. (156 aa)
algBAlginate biosynthesis transcriptional regulatory protein AlgB; Positive regulator of the alginate biosynthetic gene algD. (448 aa)
gmhBD-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. Belongs to the gmhB family. (175 aa)
PP_0034Putative bactoprenol glycosyl-transferase from phage origin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (327 aa)
PP_0033Putative undecaprenyl-glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (484 aa)
PP_0024Putative membrane-associated metal-dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (565 aa)
PP_1033Sulfatase domain protein. (662 aa)
algCPhosphomannomutase/phosphoglucomutase; The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for biofilm production (By similarity). (463 aa)
opgGGlucans biosynthesis protein G; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (559 aa)
opgHGlucans biosynthesis glucosyltransferase H; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (857 aa)
PP_4978Homologs of previously reported genes of unknown function. (361 aa)
PP_4943Putative Glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (376 aa)
PP_4942Homologs of previously reported genes of unknown function. (298 aa)
PP_4940Putative glycosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (318 aa)
PP_4938Putative Glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (379 aa)
wzyO-antigen polymerase. (391 aa)
waaA3-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (423 aa)
PP_4592Putative metal dependent hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknownfunction : Enzymes of unknown specificity. (545 aa)
glgEAlpha-1,4-glucan:maltose-1-phosphate maltosyltransferase; Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB. (661 aa)
glgB1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (736 aa)
glgAGlycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (519 aa)
galUUTP-glucose-1-phosphate uridylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Sugars. (279 aa)
PP_3142Putative Sugar transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (473 aa)
PP_3141Glycosyl transferase, WecB/TagA/CpsF family; Belongs to the glycosyltransferase 26 family. (250 aa)
PP_3140Glycosyl transferase, group 2 family protein. (395 aa)
PP_3139Glycosyl transferase, group 1 family protein. (400 aa)
PP_3137Glycosyl transferase, group 2 family protein. (325 aa)
PP_3135Putative Glycosyl transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (318 aa)
PP_3132Putative Polysaccharide transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (458 aa)
PP_3128Putative Exopolysaccharide biosynthesis/transport protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (268 aa)
PP_3127Putative Exopolysaccharide transport protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (512 aa)
PP_3126Putative polysaccharide exported protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (185 aa)
PP_3016Putative Lipopolysaccharide core biosynthesis protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (277 aa)
PP_2974Putative sulfatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Unknown function. (550 aa)
udgUDP-glucose 6-dehydrogenase. (442 aa)
PP_2852Putative Sulfatase domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (733 aa)
bcsBCellulose synthase and translocator subunit; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); Belongs to the AcsB/BcsB family. (760 aa)
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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