(15 nodes) ACT domain network (Pseudomonas putida KT2440)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	purU-I	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
	PP_0357	ACT domain protein. (172 aa)
	PP_0997	Sigma-54 dependent transcriptional regulator/sensory box protein. (502 aa)
	purU-II	Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
	hom	Homoserine dehydrogenase. (434 aa)
	glnD	Uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (900 aa)
	relA	ATP:GTP 3'-pyrophosphotransferase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (746 aa)
	pheA	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme. (367 aa)
	spoT	Bifunctional (p)ppGpp synthase/hydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa)
	serA	D-3-phosphoglycerate dehydrogenase / alpha-ketoglutarate reductase; Function experimentally demonstrated in the studied species; enzyme; Aminoacidbiosynthesis : Serine family; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
	serB	Phosphoserine phosphatase; Function experimentally demonstrated in the studied genus; enzyme; Aminoacidbiosynthesis : Serine family. (415 aa)
	ilvH	Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family. (163 aa)
	phhR	Sigma-54 dependent transcriptional regulator; Function experimentally demonstrated in the studied strain; regulator; Fattyacidandphospholipidmetabolism : Degradation. (519 aa)
	lysC	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate. (411 aa)
	purU-III	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (286 aa)

Your Current Organism:

Pseudomonas putida KT2440

NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PP_0997	pheA	PP_0997	PP_1769	Sigma-54 dependent transcriptional regulator/sensory box protein.	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	0.406
hom	ilvH	PP_1470	PP_4679	Homoserine dehydrogenase.	Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family.	0.815
hom	lysC	PP_1470	PP_4473	Homoserine dehydrogenase.	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate.	0.984
hom	pheA	PP_1470	PP_1769	Homoserine dehydrogenase.	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	0.875
hom	serA	PP_1470	PP_5155	Homoserine dehydrogenase.	D-3-phosphoglycerate dehydrogenase / alpha-ketoglutarate reductase; Function experimentally demonstrated in the studied species; enzyme; Aminoacidbiosynthesis : Serine family; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.713
ilvH	hom	PP_4679	PP_1470	Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family.	Homoserine dehydrogenase.	0.815
ilvH	pheA	PP_4679	PP_1769	Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family.	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	0.781
ilvH	serA	PP_4679	PP_5155	Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family.	D-3-phosphoglycerate dehydrogenase / alpha-ketoglutarate reductase; Function experimentally demonstrated in the studied species; enzyme; Aminoacidbiosynthesis : Serine family; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.412
lysC	hom	PP_4473	PP_1470	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate.	Homoserine dehydrogenase.	0.984
lysC	pheA	PP_4473	PP_1769	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate.	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	0.679
lysC	purU-I	PP_4473	PP_0327	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.449
lysC	purU-II	PP_4473	PP_1367	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate.	Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.449
lysC	purU-III	PP_4473	PP_1943	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.449
lysC	serB	PP_4473	PP_4909	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate.	Phosphoserine phosphatase; Function experimentally demonstrated in the studied genus; enzyme; Aminoacidbiosynthesis : Serine family.	0.469
pheA	PP_0997	PP_1769	PP_0997	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	Sigma-54 dependent transcriptional regulator/sensory box protein.	0.406
pheA	hom	PP_1769	PP_1470	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	Homoserine dehydrogenase.	0.875
pheA	ilvH	PP_1769	PP_4679	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	Acetohydroxybutanoate synthase / acetolactate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Pyruvate family.	0.781
pheA	lysC	PP_1769	PP_4473	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	Aspartokinase; Involved in the biosynthesis of L-aspartate-beta-semialdehyde which is a central intermediate in the biosynthesis of different amino acids (L-lysine, L-methionine, L-threonine). Catalyzes the phosphorylation of the beta-carboxyl group of L-aspartate to yield 4- phospho-L-aspartate.	0.679
pheA	phhR	PP_1769	PP_4489	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	Sigma-54 dependent transcriptional regulator; Function experimentally demonstrated in the studied strain; regulator; Fattyacidandphospholipidmetabolism : Degradation.	0.648
pheA	purU-I	PP_1769	PP_0327	Chorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme.	Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.429