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algD algD gacS gacS pheA pheA ihfB ihfB hupB hupB ihfA ihfA benR benR algP algP kguT kguT kguE kguE hupA hupA bkdR bkdR zwf zwf zwfB zwfB PP_0652 PP_0652 mdh mdh rpoN rpoN hupN hupN gapA gapA edd edd gtsA gtsA zwfA zwfA glpF glpF algA algA algF algF alg8 alg8
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
algDGDP-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics (By similarity). (438 aa)
gacSSensor protein GacS. (917 aa)
pheAChorismate mutase/Prephenate dehydratase; Function of strongly homologous gene; enzyme. (367 aa)
ihfBIntegration host factor subunit beta; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (100 aa)
hupBDNA binding regulator, beta subunit B; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
ihfAIntegration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (100 aa)
benRBenABC operon transcriptional activator; Function experimentally demonstrated in the studied species; regulator; Energy metabolism. (318 aa)
algPTranscriptional regulatory protein AlgP. (329 aa)
kguT2-ketogluconate transporter, putative; Function experimentally demonstrated in the studied genus; transporter; Transportandbindingproteins : Carbohydrates, organic alcohols, and acids. (430 aa)
kguEPutative epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Energy metabolism. (259 aa)
hupADNA-binding protein HU-alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (99 aa)
bkdRBkd operon transcriptional regulator; Function experimentally demonstrated in the studied species; regulator; Regulatory functions. (161 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (485 aa)
zwfBGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (501 aa)
PP_0652Gluconate transporter. (461 aa)
mdhPutative malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (310 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the xylCAB operon and the xylS gene. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein XylR for the expression of the xylCAB operon and xylS. (497 aa)
hupNPutative DNA-binding protein HU, form N; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator; Belongs to the bacterial histone-like protein family. (93 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Function experimentally demonstrated in the studied strain; enzyme; Energymetabolism : Entner-Doudoroff; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa)
gtsAMannose/glucose ABC transporter, glucose-binding periplasmic protein; Function experimentally demonstrated in the studied strain; transporter; Transport and binding proteins. (428 aa)
zwfAGlucose 6-phosphate-1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa)
glpFAquaglyceroporin; Function of homologous gene experimentally demonstrated in an other organism; transporter; Fattyacidandphospholipidmetabolism : Biosynthesis; Belongs to the MIP/aquaporin (TC 1.A.8) family. (283 aa)
algAMannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics (By similarity). (485 aa)
algFAlginate biosynthesis protein AlgF; Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases the ability of alginate to act as a defense barrier (By similarity). (215 aa)
alg8Glycosyltransferase alg8; Possibly a processive enzyme that polymerizes GDP-mannuronic acid. (496 aa)
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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