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pstC pstC proB proB rpoN rpoN guaB guaB guaA guaA thrC thrC glnD glnD relA relA pyrF pyrF asd asd ppsA ppsA cysB cysB aroE-2 aroE-2 gabP-II gabP-II PP_2608 PP_2608 pstS pstS ribA ribA pstA pstA gabP-III gabP-III ribC ribC aroE-3 aroE-3 ilvA-I ilvA-I PP_3613 PP_3613 PP_3768 PP_3768 purB purB gabP-IV gabP-IV PP_4407 PP_4407 argT argT cysK cysK proA proA purA purA pde pde pyrB pyrB glnA glnA glnG glnG ilvA-II ilvA-II ppk ppk xpt xpt phoR phoR phoU phoU glnE glnE gabP-I gabP-I ssuA ssuA trpA trpA aroE aroE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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pstCPhosphate ABC transporter; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (322 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the xylCAB operon and the xylS gene. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein XylR for the expression of the xylCAB operon and xylS. (497 aa)
guaBIMP dehydrogenase and single strand DNA binding factor; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
guaAGlutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (525 aa)
thrCThreonine synthase. (469 aa)
glnDUridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (900 aa)
relAATP:GTP 3'-pyrophosphotransferase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (746 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (233 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa)
ppsAPhosphoenolpyruvate synthetase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (791 aa)
cysBTranscriptional dual regulator / CysB-O-acetyl-L-serine; Function of homologous gene experimentally demonstrated in an other organism; regulator; Aminoacidbiosynthesis : Serine family; Belongs to the LysR transcriptional regulatory family. (324 aa)
aroE-2Putative quinate/shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (282 aa)
gabP-IIGamma-aminobutyrate permease; Function of homologous gene experimentally demonstrated in an other organism; transporter. (470 aa)
PP_2608Shikimate dehydrogenase family protein. (269 aa)
pstSPhosphate ABC transporter; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (348 aa)
ribAGTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (205 aa)
pstAPhosphate ABC transporter; Function experimentally demonstrated in the studied genus; transporter; Centralintermediarymetabolism : Phosphorus compounds. (297 aa)
gabP-IIIGamma-aminobutyrate permease; Function of homologous gene experimentally demonstrated in an other organism; transporter; Transportandbindingproteins : Carbohydrates, organic alcohols, and acids. (463 aa)
ribCRiboflavin synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Biosynthesisofcofactors,prostheticgroups,andcarriers : Riboflavin, FMN, and FAD. (209 aa)
aroE-3Shikimate dehydrogenase-related enzyme; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
ilvA-IThreonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (530 aa)
PP_3613L-sorbosone dehydrogenase. (430 aa)
PP_3768Putative shikimate 5-dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Amino acid biosynthesis. (273 aa)
purB5'-phosphoribosyl-4-(N-succinocarboxamide)-5- aminoimidazole lyase (adenylosuccinate lyase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Purines,pyrimidines,nucleosides,andnucleotides : Purine ribonucleotide biosynthesis; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
gabP-IVGamma-aminobutyrate permease; Function of homologous gene experimentally demonstrated in an other organism; transporter. (460 aa)
PP_4407Putative Gamma-aminobutyrate transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (460 aa)
argTLysine / arginine / ornithine ABC transporter - periplasmic binding protein; Function of homologous gene experimentally demonstrated in an other organism; transporter; Aminoacidbiosynthesis : Aspartate family. (261 aa)
cysKCysteine synthase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Serine family; Belongs to the cysteine synthase/cystathionine beta- synthase family. (324 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (423 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
pde3',5'-cyclic-nucleotide phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (266 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (334 aa)
glnAGlutamine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Aminoacidbiosynthesis : Glutamate family. (468 aa)
glnGTwo-component system DNA-binding transcriptional dual regulator GlnL/GlnG; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (478 aa)
ilvA-IIThreonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (727 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
phoRTwo-component system sensory histidine kinase; Function experimentally demonstrated in the studied strain; receptor; Centralintermediarymetabolism : Phosphorus compounds. (435 aa)
phoUPhosphate transport-associated protein; Plays a role in the regulation of phosphate uptake. (256 aa)
glnEGlutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (977 aa)
gabP-IGamma-aminobutyrate permease; Function of homologous gene experimentally demonstrated in an other organism; transporter. (461 aa)
ssuAAliphatic sulfonate ABC transporter - periplasmic binding protein / transport of isethionate; Function of homologous gene experimentally demonstrated in an other organism; transporter; Centralintermediarymetabolism : Sulfur metabolism. (321 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa)
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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