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spuF spuF ppk ppk amaB amaB recG recG phoB phoB phoU phoU betI betI phoP phoP livK livK livH livH livM livM livG livG sodA sodA sodB sodB uvrA uvrA potA potA metQ metQ recO recO recA recA csrA-2 csrA-2 nagZ nagZ pstS pstS pstC pstC pstA pstA katG katG csrA-3 csrA-3 treZ treZ treY treY uvrC uvrC csrA csrA recD recD recB recB recC recC betB betB betA-II betA-II recF recF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
spuFSpermidine/putrescine ABC transporter - ATP binding subunit; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (380 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (727 aa)
amaBL-piperidine-6-carboxylate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Amino acids and amines; Belongs to the aldehyde dehydrogenase family. (496 aa)
recGJunction-specific ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (692 aa)
phoBTwo-component system DNA-binding transcriptional dual response regulator PhoB; Function experimentally demonstrated in the studied strain; regulator; Centralintermediarymetabolism : Phosphorus compounds. (242 aa)
phoUPhosphate transport-associated protein; Plays a role in the regulation of phosphate uptake. (256 aa)
betICholine-responsive transcriptional repressor BetI; Repressor involved in choline regulation of the bet genes. (218 aa)
phoPTwo component system DNA-binding transcriptional dual regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Transcription. (225 aa)
livKBranched-chain amino acids ABC transporter - periplasmic leucine binding subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter; Aminoacidbiosynthesis : Pyruvate family. (371 aa)
livHBranched chain amino acid transporter - permease subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter; Aminoacidbiosynthesis : Pyruvate family; Belongs to the binding-protein-dependent transport system permease family. (307 aa)
livMBranched chain amino acid transporter - permease subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter; Aminoacidbiosynthesis : Pyruvate family; Belongs to the binding-protein-dependent transport system permease family. (418 aa)
livGBranched chain amino acid transporter - ATP binding subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter; Aminoacidbiosynthesis : Pyruvate family. (255 aa)
sodASuperoxide dismutase (Mn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (210 aa)
sodBSuperoxide dismutase (Fe); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (198 aa)
uvrAExcinuclease (uvrABC system protein A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (944 aa)
potAPolyamine ABC transporter, ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (374 aa)
metQMethionine ABC transporter, periplasmic binding protein; Function of homologous gene experimentally demonstrated in an other organism; transporter. (256 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (227 aa)
recAProtein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (355 aa)
csrA-2Putative carbon storage regulator, csrA-like; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (59 aa)
nagZbeta-N-acetylglucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (336 aa)
pstSPhosphate ABC transporter; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family. (348 aa)
pstCPhosphate ABC transporter; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (322 aa)
pstAPhosphate ABC transporter; Function experimentally demonstrated in the studied genus; transporter; Centralintermediarymetabolism : Phosphorus compounds. (297 aa)
katGCatalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (751 aa)
csrA-3Carbon storage regulator (csrA-like); A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (65 aa)
treZMalto-oligosyltrehalose trehalohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Biosynthesis and degradation of polysaccharides. (580 aa)
treYMaltooligosyl trehalose synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Energymetabolism : Biosynthesis and degradation of polysaccharides. (924 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (607 aa)
csrACarbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (62 aa)
recDATP-dependent DNA helicase and dsDNA/ssDNA exonuclease, ssDNA endonuclease; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA f [...] (691 aa)
recBChi activated ATP-dependent DNA helicase and dsDNA/ssDNA exonuclease; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for hom [...] (1224 aa)
recCATP-dependent DNA helicase and dsDNA/ssDNA exonuclease, ssDNA endonuclease, recombinase subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-b [...] (1160 aa)
betBBetaine aldehyde dehydrogenase, NAD-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. (490 aa)
betA-IICholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (565 aa)
recFDNA replication and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (367 aa)
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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