STRINGSTRING
ANF80760.1 ANF80760.1 ANF80761.1 ANF80761.1 acsA acsA fadA fadA fadB fadB ANF80885.1 ANF80885.1 ANF80916.1 ANF80916.1 ANF80940.1 ANF80940.1 ANF81021.1 ANF81021.1 ANF81022.1 ANF81022.1 ackA ackA ANF81094.1 ANF81094.1 ANF81095.1 ANF81095.1 ANF81146.1 ANF81146.1 gabD gabD ANF81257.1 ANF81257.1 ANF81287.1 ANF81287.1 A3K93_03480 A3K93_03480 ANF81346.1 ANF81346.1 ANF81347.1 ANF81347.1 ANF81348.1 ANF81348.1 ANF81349.1 ANF81349.1 ANF83085.1 ANF83085.1 ANF81350.1 ANF81350.1 ANF81351.1 ANF81351.1 sucC sucC sucD sucD pckG pckG fadH fadH ANF81464.1 ANF81464.1 lipA lipA ANF81473.1 ANF81473.1 ANF81482.1 ANF81482.1 ANF81521.1 ANF81521.1 ANF81593.1 ANF81593.1 pgk pgk ANF81676.1 ANF81676.1 rpiA rpiA prpB prpB ANF81731.1 ANF81731.1 fumC fumC ANF81779.1 ANF81779.1 gcvH gcvH ANF81837.1 ANF81837.1 eno eno fadH-2 fadH-2 ANF81892.1 ANF81892.1 ANF81916.1 ANF81916.1 ANF81917.1 ANF81917.1 ANF81946.1 ANF81946.1 ANF81950.1 ANF81950.1 glcB glcB ANF82061.1 ANF82061.1 ANF82077.1 ANF82077.1 ANF82152.1 ANF82152.1 fbp fbp ANF82201.1 ANF82201.1 ANF82202.1 ANF82202.1 ANF82220.1 ANF82220.1 ANF82236.1 ANF82236.1 prs prs lipB lipB ANF82399.1 ANF82399.1 ANF82417.1 ANF82417.1 ANF82422.1 ANF82422.1 ANF82423.1 ANF82423.1 ANF82478.1 ANF82478.1 ANF83164.1 ANF83164.1 ANF82520.1 ANF82520.1 mdh mdh ANF82558.1 ANF82558.1 ANF82559.1 ANF82559.1 ANF82615.1 ANF82615.1 tpiA tpiA gpmI gpmI pgi pgi ppc ppc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ANF80760.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (899 aa)
ANF80761.1Pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (657 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (647 aa)
fadA3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (390 aa)
fadBMultifunctional fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (717 aa)
ANF80885.1acetyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
ANF80916.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (570 aa)
ANF80940.1long-chain-acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
ANF81021.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa)
ANF81022.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (713 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa)
ANF81094.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (593 aa)
ANF81095.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (600 aa)
ANF81146.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
gabDSuccinate-semialdehyde dehydrogenase (NADP(+)); Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
ANF81257.13-oxosteroid 1-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (582 aa)
ANF81287.1Putative AcnD-accessory protein PrpF; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
A3K93_03480Metal-dependent hydrolase; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (424 aa)
ANF81346.1Succinate dehydrogenase, cytochrome b556 subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
ANF81347.1Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (120 aa)
ANF81348.1Succinate dehydrogenase flavoprotein subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
ANF81349.1Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
ANF83085.12-oxoglutarate dehydrogenase E1 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (940 aa)
ANF81350.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (406 aa)
ANF81351.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa)
fadHNADPH-dependent 2,4-dienoyl-CoA reductase; Catalyzes the formation of trans-2- enoyl-CoA from 2,4-dienoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (678 aa)
ANF81464.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (826 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (337 aa)
ANF81473.1Type I glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (485 aa)
ANF81482.1Undecaprenyl-diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
ANF81521.1Isocitrate dehydrogenase, NADP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (745 aa)
ANF81593.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (395 aa)
ANF81676.1Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (345 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa)
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (294 aa)
ANF81731.12-methylcitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (375 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
ANF81779.1Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (543 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa)
ANF81837.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa)
fadH-2NADPH-dependent 2,4-dienoyl-CoA reductase; Catalyzes the formation of trans-2- enoyl-CoA from 2,4-dienoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (674 aa)
ANF81892.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (879 aa)
ANF81916.1Phosphoenolpyruvate synthase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (278 aa)
ANF81917.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (790 aa)
ANF81946.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (501 aa)
ANF81950.1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (329 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (721 aa)
ANF82061.1Erythrose-4-phosphate dehydrogenase; NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa)
ANF82077.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
ANF82152.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
fbpFructose-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (324 aa)
ANF82201.1Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
ANF82202.1Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
ANF82220.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (759 aa)
ANF82236.1Isocitrate lyase; Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (219 aa)
ANF82399.1Fe/S-dependent 2-methylisocitrate dehydratase AcnD; Derived by automated computational analysis using gene prediction method: Protein Homology. (867 aa)
ANF82417.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
ANF82422.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
ANF82423.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (710 aa)
ANF82478.1acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
ANF83164.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa)
ANF82520.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
ANF82558.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
ANF82559.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
ANF82615.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (607 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa)
gpmIPhosphoglycerate mutase (2,3-diphosphoglycerate-independent); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (516 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (556 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (894 aa)
Your Current Organism:
Acinetobacter sp. NCu2D2
NCBI taxonomy Id: 1608473
Other names: A. sp. NCu2D-2, Acinetobacter sp. NCu2D-2
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