(20 nodes) Pyruvate metabolism, and 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity network (Pyrococcus kukulkanii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	AMM53208.1	Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (91 aa)
	AMM53265.1	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
	AMM53611.1	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
	AMM53883.1	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
	vorD	2-ketoisovalerate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
	porA	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
	AMM53886.1	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
	porD	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
	porA-2	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
	AMM53889.1	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
	AMM54390.1	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
	AMM54439.1	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
	AMM54511.1	2-keto acid:ferredoxin oxidoreductase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (89 aa)
	AMM54512.1	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
	AMM54513.1	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
	AMM54516.1	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
	AMM54517.1	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
	AMM54518.1	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Catalyzes the ferredoxin-dependent oxidative decarboxylation 2-oxoglutarate forming succinyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
	AMM54657.1	Acetyl CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
	AMM54821.1	Alanine aminotransferase; Catalyzes the transamination of pyruvate or with glutamate; activity is seen with alanine, glutamate, and aspartate with either 2-oxoglutarate or pyruvate as the amino acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)

Your Current Organism:

Pyrococcus kukulkanii

NCBI taxonomy Id: 1609559
Other names: DSM 101590, P. kukulkanii, Pyrococcus kukulkanii Callac et al. 2016, Pyrococcus sp. NCB100, Souchotheque de Bretagne BG1337, strain NCB100

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMM53208.1	AMM53265.1	TQ32_00885	TQ32_01185	Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AMM53208.1	AMM53611.1	TQ32_00885	TQ32_03300	Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AMM53208.1	AMM54390.1	TQ32_00885	TQ32_07795	Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AMM53208.1	AMM54439.1	TQ32_00885	TQ32_08050	Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AMM53208.1	AMM54657.1	TQ32_00885	TQ32_09290	Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyl CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AMM53265.1	AMM53208.1	TQ32_01185	TQ32_00885	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AMM53265.1	AMM53611.1	TQ32_01185	TQ32_03300	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.905
AMM53265.1	AMM53883.1	TQ32_01185	TQ32_04845	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.674
AMM53265.1	AMM53889.1	TQ32_01185	TQ32_04875	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.675
AMM53265.1	AMM54390.1	TQ32_01185	TQ32_07795	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AMM53265.1	AMM54439.1	TQ32_01185	TQ32_08050	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
AMM53265.1	AMM54512.1	TQ32_01185	TQ32_08500	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.753
AMM53265.1	AMM54513.1	TQ32_01185	TQ32_08505	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.675
AMM53265.1	AMM54516.1	TQ32_01185	TQ32_08525	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.748
AMM53265.1	AMM54517.1	TQ32_01185	TQ32_08530	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.675
AMM53265.1	AMM54657.1	TQ32_01185	TQ32_09290	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acetyl CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.905
AMM53265.1	porA-2	TQ32_01185	TQ32_04870	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.744
AMM53265.1	porD	TQ32_01185	TQ32_04865	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.716
AMM53611.1	AMM53208.1	TQ32_03300	TQ32_00885	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AMM53611.1	AMM53265.1	TQ32_03300	TQ32_01185	acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.905

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